Recurrence of urinary tract infections in postmenopausal diabetic women using different antibiotics


Objectives: Postmenopausal women with diabetes mellitus (DM) have an increased incidence of urinary tract infections (UTI) compared to women without DM. The aim of this study is to compare recurrence rates of UTI in postmenopausal women with DM after treatment with nitrofurantoin, the agent of first choice following the Dutch guidelines, with two other common prescribed antibiotics trimethoprim and norfloxacin. Methods: We used a PHARMO database with pharmacy dispensing data. A total of 8534 postmenopausal (>55 years) women with DM who received a first course of nitrofurantoin, trimethoprim or norfloxacin were included. The UTI recurrence rates after treatment with these three different antimicrobial agents were compared. Recurrence was defined as a second prescription for nitrofurantoin, trimethoprim or norfloxacin or a first with fosfomycin, amoxicillin, fluoroquinolones, or trimethoprim/sulfamethoxazole between 6 and 30 days after inclusion. Results: Postmenopausal women with DM had significantly more UTI recurrences when they were treated with nitrofurantoin (22.7%) compared to trimethoprim (17.7%) or norfloxacin (14.2%) irrespective of the treatment duration. There was a trend that longer treatment duration was associated with higher recurrence rates. Conclusions: Postmenopausal women with DM had more UTI recurrences when they are treated with nitrofurantoin, agent of first choice, compared to trimethoprim or norfloxacin.

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Schneeberger, C. , P. Stolk, R. , Hans DeVries, J. , M. C. Herings, R. and E. Geerlings, S. (2012) Recurrence of urinary tract infections in postmenopausal diabetic women using different antibiotics. Journal of Diabetes Mellitus, 2, 261-263. doi: 10.4236/jdm.2012.22042.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Nicolle, L.E. (2005) Urinary tract infection in diabetes. Current Opinion in Infections Disease, 18, 49-53. doi:10.1097/00001432-200502000-00009
[2] Shah, B.R. and Hux, J.E. (2003) Quantifying the risk of infectious diseases for people with diabetes. Diabetes Care, 26, 510-513. doi:10.2337/diacare.26.2.510
[3] Carton, J.A., Maradona, J.A., Nuno, F.J., Fernandez-Alvarez, R., Perez-Gonzalez, F. and Asensi, V. (1992) Diabetes mellitus and bacteraemia: A comparative study between diabetic and non-diabetic patients. European Journal of Medicine, 1, 281-287
[4] Nicolle, L.E. (2001) A practical guide to antimicrobial management of complicated urinary tract infection. Drugs and Aging, 18, 243-254. doi:10.2165/00002512-200118040-00002
[5] Schneeberger, C., Stolk, R.P., Devries, J.H., Schneeberger, P.M., Herings, R.M. and Geerlings, S.E. (2008) Differences in the pattern of antibiotic prescription profile and recurrence rate for possible urinary tract infections in women with and without diabetes. Diabetes Care, 31, 1380-1385. doi:10.2337/dc07-2188
[6] Lawrenson, R.A. and Logie, J.W. (2001) Antibiotic failure in the treatment of urinary tract infections in young women. Journal of Antimicrobial Chemotherapy, 48, 895-890.doi:10.1093/jac/48.6.895
[7] Charalabopoulos, K., Karachalios, G., Baltogiannis, D., Charalabopoulos, A., Giannakopoulos, X. and Sofikitis, N. (2003) Penetration of antimicrobial agents into the prostate. Chemotherapy, 49, 269-279. doi:10.1159/000074526

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