Antiurolithiatic activity of aqueous extract of bark of moringa oleifera (lam.) in rats

Abstract

In the present study, aqueous extract of bark of Moringa oleifera administered orally, was eva- luated for its antiurolithiatic potential in albino rats of Wistar strains. The stones were produced in this study by zinc disc foreign body insertion in the bladder supplemented with 1% ethylene glycol in drinking water. The reduction in weight of the stones was used as criteria for assessing the preventive or curative antiurolithiatic effect of the bark of this plant. Two doses of extract for prophylactic and curative groups were used. In both groups the oral administration of the extract of bark of Moringa oleifera has resulted in significant reduction in the weight of bladder stones compared to the control group.

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Fahad, J. , ., V. , Kumar, M. , ., S. , Kodancha, G. , Adarsh, B. , Udupa, A. and Rathnakar, U. (2010) Antiurolithiatic activity of aqueous extract of bark of moringa oleifera (lam.) in rats. Health, 2, 352-355. doi: 10.4236/health.2010.24053.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Basu, B.D. and Kirtikar, K.R. (1980) Indian Medicinal Plants, second edn, Bishen Singh Mahendra Pal Singh, Dehradun, 1, 676-683.
[2] Nadkarni, A.K. (2002) K.M.Nadkarni’s Indian Materia Medica, Popular prakashana, Bombay, 3rd edition, 1, 811-816.
[3] Vaidyaratnam, P.S.V. (1994) Indian Medicinal Plants-A Compendium of 500 Species. Orient Longman Ltd., Madras, 4, 59-64.
[4] Fahey, J.W. (2005) Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Part 1. Trees for Life Journal, December, 1(5).
[5] Udupa, S.L., Udupa, A.L. and Kulkarni, D.R. (1994) Studies on the anti-inflammatory and wound healing properties of Moringa oleifera and Aegle marmelos, Fitoterapia, 65, 119-123.
[6] Udupa, S.L., Udupa, A.L. and Kulkarni, D.R., (1998) A comparative study on the effect of some indigenous drugs on normal and steroid-depressed healing. Fitoterapia, 69, 507-510.
[7] Guevara, A.P., Vargas, C. and Uy, M. (1996) Anti-in- flammatory and antitumor activities of seed extracts of malunggay, Moringa oleifera L. (Moringaceae), Philippine Journal of Science, 125, 175-184.
[8] Ruckmani, K., Kavimani, S., Anandan, R. and Jaykar, B, (1998) Effect of Moringa oleifera Lam. on paracetamol induced hepatotoxicity, Indian Journal of Pharmaceutical Science, 60, 33-35.
[9] Prakash, A.O., Pathak, S., Shukla, S. and Mathur, R. (1988) Pre and post-implantation changes in the uterus of rats: Response to Moringa oleifera Lam. extract, Ancient Science of Life, 8, 49-54.
[10] Faizi, S., Siddiqui, B.S., Saleem, R., Siddiqui, S., Aftab, K. and Gilani, A.H. (1995) Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry, 38, 957-963.
[11] Ravindra, V.K., Navneet, B.G., Alagawadi, K.R. and Rudraprabhu, V.S. (2006) Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats. Journal of Ethnopharmacology, 105(1-2), 306-311.
[12] Caceres A., Saravia A., Rizzo, S., Zabala, L., De Leon, E. and Nave F. (1992) Pharmacological properties of Moringa oleifera 2: Screening for antispasmodic anti-inflammatory and diuretic activity. Journal of Ethnopharmacology, 36, 233-237.
[13] Ezeamuzi, I.C., Ambakederemo, A.W., Shode, F.O. and Ekwebelem, S.C. (1996) Antiinflammatory effects of Moringa leifera root extract. Journal of Pharmacognosy, 34, 207-212.
[14] Rao, C.V., Ojha, S.K. and Mehrotra. S. (2003) Analgesic effect of Moringa oleifera leaf extract on rats, Proceedings of the Second World Congress on Biotechnologi cal Developments of Herbal Medicine Lucknow, India, 42.
[15] Marshall, L. and Stoller, M.D. (2004) Urinary stone disease, in Smith’s General Urology; Emil A, Tanagho, Jack W, Aninch M. Eds., Lange medical books, 16th ed., New York, 256-291.
[16] Moe, O.W. (2006) Kidney stones: Pathophysiology and medical management. Lancet Jan, 367(9507), 333-344.
[17] Prasad, K.V.S.R.G., Sujatha, D. and Bharathi, K. (2007) Herbal Drugs in Urolithiasis-A Review. Pharmacognosy Reviews, 1(1), 175-179.
[18] Vargas, S.R. and Perez, G.R.M. (2002) Antiurolithiatic activity of Salix taxifolia aqueous extract. Pharmaceutical Biology, 40(8), 561-563.
[19] Satoh, M., Munakata, K., Kitoh, K., Takeuchi, H. and Yoshida, O. (1984) A newly designed model for infection-induced bladder stone formation in the rat. The Journal of Urology, 132(6), 1247-1249.
[20] Reyes, L., Reinhard, M., O’Donell, L.J., Stevens, J. and Brown, M.B. (2006) Rat strains differ in susceptibility to ureaplasma parvum-induced urinary tract infection and struvite stone formation. Infection and Immunity, 74(12), 6656-6664.

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