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Effect of Aripiprazole on Methamphetamine-Induced Disruption of Latent Inhibition in Rats

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DOI: 10.4236/jbbs.2011.13022    4,142 Downloads   8,966 Views   Citations

ABSTRACT

Objectives: To elucidate the pharmacological profile of aripiprazole, we examined its ameliorating effect on the methamphetamine-induced disruption of latent inhibition (LI) in rats. Method: The effect was measured using a conditioned emotional response procedure. The conditioned stimulus was a tone (2.8 kHz, 90 dB), and the unconditioned stimulus was a mild foot shock delivered through a floor grid. The conditioning procedure was repeated five times. Results: Methamphetamine-induced (1.0 mg/kg, i.p.) disruption of LI was ameliorated by the administration of haloperidol (0.2 mg/kg, i.p.) and by a moderate dose of aripiprazole (0.3 mg/kg, i.p.) but not by a lower or higher dose (0.1 or 3.0 mg/kg, i.p.) of aripiprazole. However, immunohistochemical examination showed increased levels of c-Fos expression in the shell of the nucleus accumbens after the administration of haloperidol (0.2 mg/kg, i.p.) but not of aripiprazole (0.3 mg/kg, i.p.). Conclusions: It is suggested that aripiprazole has an ameliorating effect on methamphetamine-induced disruption of latent inhibition within only a marginal therapeutic window.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

H. Matsuo, H. Abe, T. Ikeda, K. Ebihara, R. Takeda, T. Nishimori and Y. Ishida, "Effect of Aripiprazole on Methamphetamine-Induced Disruption of Latent Inhibition in Rats," Journal of Behavioral and Brain Science, Vol. 1 No. 3, 2011, pp. 167-171. doi: 10.4236/jbbs.2011.13022.

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