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Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

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DOI: 10.4236/jbm.2015.312005    1,879 Downloads   2,122 Views   Citations

ABSTRACT

Streptococcus pyogenesis most popularpathogen caused respiratory tract infection disease. This study was conducted to find out the recent clinical characteristics of Streptococcus pyogenes isolates from respiratory tract at Japanese hospital in 2014. Streptococcus pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Respiratory tract isolates were defined as isolation from pharynx, nasal discharge, tonsillar, and sputum. Total one hundred sixty-one Streptococcus pyogenes were isolated among which 136 were from respiratory tract and 25 were from non- respiratory tract. Respiratory tract-associated Streptococcus pyogenes was isolated among which 102 were from male and 59 were from female. The age incidence among 0 - 1 years age group was 8, among 1 - 18 years age group, 131 (p < 0.01), among 19 - 64 years age group, 17 (p < 0.01), and in 65-years it was 5. Although we investigated the relationship between season and bacterial isolation, we did not find any significant differences between respiratory tract and no respiratory tract isolation. However, our study revealed that clarithromycin was less antimicrobial effective in respiratory tract disease than in no respiratory tract disease significantly (p < 0.01). Although several antibiotics such as penicillin are still effective against Streptococcus pyogenes, incidence of Streptococcus pyogenes infection is not decreasing worldwide. Our study suggests the need for continuous epidemiological surveillance of Streptococcus pyogenes.

 

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Minami, M. , Sakakibara, R. , Imura, T. , Watanabe, M. , Morita, H. , Kanemaki, N. and Ohta, M. (2015) Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014. Journal of Biosciences and Medicines, 3, 26-31. doi: 10.4236/jbm.2015.312005.

References

[1] Tart, A.H., Walker, M.J. and Musser, J.M. (2007) New Understanding of the Group A Streptococcus Pathogenesis Cycle. Trends. Microbiol., 15, 318-325. http://dx.doi.org/10.1016/j.tim.2007.05.001
[2] Stevens, D.L. (2000). Group A Beta-Hemolytic Streptococci: Virulence Factors, Pathogenesis, and Spectrum of Clinical Infections. In: Stevens, D.L. and Kaplan, E.L., Eds., Streptococcal Infections, Oxford University Press, New York, 19-36.
[3] Gawaorzewska, E. and Colman, G. (1988) Changes in the Patterns of Infection Caused by Streptococcus pyogenes. Epidemiol Infect., 100, 257-269. http://dx.doi.org/10.1017/S095026880006739X
[4] Anjos, L.M., Marcondes, M.B., Lima, M.F., Mondelli, A.L. and Okoshi, M.P. (2014) Streptococcal Acute Pharyngitis. Rev Soc Bras Med Trop., 47, 409-413. http://dx.doi.org/10.1590/0037-8682-0265-2013
[5] Cho, K.H. and Caparon, M. (2006) Genetic of Group A Strepto-cocci. In: Fischetti, V.A., Novick, R.P., Ferretti, J.J., Portnoy, D.A. and Rood, J.I., Eds., Gram Positive Pathogens, ASM Press, Washington DC, 59-73.
[6] Tan, L.K., Eccersley, L.R. and Sriskandan, S. (2014) Current Views of Haemolytic Streptococcal Pathogenesis. Curr Opin Infect Dis., 27, 155-164. http://dx.doi.org/10.1097/QCO.0000000000000047
[7] Wajima, T., Chiba, N., Morozumi, M., Shouji, M., Sunaoshi, K., Sugita, K., Tajima, T. and Ubukata, K., GAS Surveillance Study Group (2014) Prevalence of Macrolide Resistance among Group A Streptococci Isolated from Pharyngotonsillitis. Microb Drug Resist., 20, 431-435. http://dx.doi.org/10.1089/mdr.2013.0213
[8] Clinical and Laboratory Standards Institute (CLSI) (2014) Performance Standards for Antimicrobial Susceptibility Testing: 24th Informational Supplement, Clinical and Laboratory Standards Institute M100-S24, Wayne.
[9] Goto, H., Shimada, K., Ikemoto, H. and Oguri, T., Study Group on Antimicrobial Susceptibility of Pathogens Isolated from Respiratory Infections (2009)Antimicrobial Susceptibility of Pathogens Isolated from More than 10,000 Patients with Infectious Respiratory Diseases: A 25-Year Longitudinal Study. J Infect Chemother., 15, 347-360. http://dx.doi.org/10.1007/s10156-009-0719-3
[10] Cervin, A. and Wallwork, B. (2007) Macrolide Therapy of Chronic Rhinosinusitis. Rhinology, 45, 259-267.
[11] Kudoh, S. and Keicho, N. (2012) Diffuse Panbronchiolitis. Clin Chest Med., 33, 297-305. http://dx.doi.org/10.1016/j.ccm.2012.02.005
[12] Michos, A.G., Bakoula, C.G., Braoudaki, M., Koutouzi, F.I., Roma, E.S., Pangalis, A., Nikolopoulou, G., Kirikou, E. and Syriopoulou, V.P. (2009) Macrolide Resistance in Streptococcus pyogenes: Prevalence, Resistance Determinants, and EMM Types. Diagn Microbiol Infect Dis., 64, 295-299. http://dx.doi.org/10.1016/j.diagmicrobio.2009.03.004
[13] Sherertz, R.J., Bassetti, S. and Bassetti-Wyss, B. (2001) “Cloud” Health-Care Workers. Emerg Infect Dis., 7, 241-244. http://dx.doi.org/10.3201/eid0702.010218

  
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