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Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing

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DOI: 10.4236/ijcm.2015.612119    2,376 Downloads   2,817 Views   Citations

ABSTRACT

Background: The relationship between growth hormone (GH) and cytokines remains unclear. Several studies have suggested that GH increases tumor necrosis factor (TNF)-α production in both children and adults. However, a number of studies have demonstrated a negative correlation between GH and TNF α. The aim of this study is to explore the relationship between endogenous GH secretion and certain pro and anti-inflammatory cytokines in short children undergoing GH stimulation testing for evaluation for GH deficiency. Methods: Plasma growth hormone, TNF α, CRP, IL-6, IL1-β, IL-4 and IL-10 levels are obtained at baseline and every 30 minutes for 150 minutes following two provocative agents (clonidine, and either arginine or glucagon). Results: Among the 23 children, 7 are found to be GH deficient. No significant differences in baseline TNF α levels are found between GH deficient and GH sufficient children. No correlation is identified between TNF α levels and GH levels during stimulation testing. Furthermore, no relationship is found between GH and pro-inflammatory cytokines or GH and anti-inflammatory cytokines. Conclusion: Our results do not demonstrate an acute relationship between endogenous GH secretion and the cytokines examined.

Cite this paper

Tafuri, K. , Dixon, D. , Markarian, K. , Lane, A. and A. Wilson, T. (2015) Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing. International Journal of Clinical Medicine, 6, 912-918. doi: 10.4236/ijcm.2015.612119.

Conflicts of Interest

The authors declare no conflicts of interest.

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