Share This Article:

Renal Cortical Necrosis: An Unusual Complication of Plasmodium malariae Malaria

Full-Text HTML XML Download Download as PDF (Size:518KB) PP. 99-104
DOI: 10.4236/ojneph.2015.54015    3,434 Downloads   3,707 Views  

ABSTRACT

Renal cortical necrosis (RCN) is anecdotal in malaria. To our knowledge, RCN secondary to Plasmodium malariae has not yet been published. We report a case of severe malaria complicated by RCN. A 29 year old Senegalese patient was transferred to our department for anuria in a context of severe malaria. The diagnosis was RCN secondary to a severe Plasmodium malariae malaria. Physical examination showed anuria, anaemic syndrome, haemorrhagic syndrome and a generally impaired condition. There was a normocytic normochromic anaemia aplastic, thrombocytopenia leukocytosis of 11.580/mm3, serum creatinine of 12.45 mg/dl and blood urea of 252 mg/dl. The Plasmodium malariae had been shown to thick blood film with high parasite density. The molecular study was able to confirm the infestation of this parasite. Treatment consisted of four haemodialysis sessions and antimalarial molecules. Initial evolution was favourable with a recovery through diuresis and a partial improvement in renal function. Given the persistence of impaired renal function, a renal biopsy was performed. This confirmed the RCN. At last consultation, he had no symptoms and his last glomerular filtration rate (GFR) was 30 mL/min/1.73 m2.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Lemrabott, A. , Moustapha Cissé, M. , Seck, S. , Fary Ka, E. , Faye, M. , Ndongo, A. , Dial, C. , Keita, Y. , Fall, K. , Niang, A. and Diouf, B. (2015) Renal Cortical Necrosis: An Unusual Complication of Plasmodium malariae Malaria. Open Journal of Nephrology, 5, 99-104. doi: 10.4236/ojneph.2015.54015.

References

[1] White, N.J., Pukrittayakamee, S., Hien, T.T., Faiz, M.A., et al. (2014) Malaria. The Lancet, 383, 723-735.
http://dx.doi.org/10.1016/S0140-6736(13)60024-0
[2] Mishra, S.K. and Das, B.S. (2008) Malaria and Acute Kidney Injury. Seminars in Nephrology, 28, 395-408.
http://dx.doi.org/10.1016/j.semnephrol.2008.04.007
[3] Baliga, K.V., Narula, A.S., Khanduja, R., Manrai, M., Sharma, P. and Mani, N.S. (2008) Acute Cortical Necrosis in Falciparum Malaria: An Unusual Manifestation. Renal Failure, 30, 461-463.
http://dx.doi.org/10.1080/08860220801964293
[4] Kunuanunua, T.S., Nsibu, C.N., Gini-Ehungu, J.-L., Bodi, J.M., Ekulu, P.M., et al. (2013) Acute Renal Failure and Severe Malaria in Congolese Children Living in Kinshasa, Democratic Republic of Congo. Néphrologie & Thérapeutique, 9, 160-165.
http://dx.doi.org/10.1016/j.nephro.2013.01.001
[5] Brocherion, I. and Ferlicot, S. (2008) Glomérulonéphrite et infections parasitaires. In: Noel, L.-H., Ed., Atlas de Pathologie Rénale, Flammarion, Paris, 261-283.
[6] Kute, V.B., Vanikar, A.V., Ghuge, P.P., Patel, M.P., Patel, H.V., et al. (2012) Renal Cortical Necrosis and Acute Kidney Injury Associated with Plasmodium vivax: A Neglected Human Malaria Parasite. Parasitology Research, 111, 2213-2216.
http://dx.doi.org/10.1007/s00436-012-2975-x
[7] Singhal, M.K., Arora, P., Kher, V., Pandey, R., Gulati, S., et al. (1997) Acute Cortical Necrosis in Falciparum Malaria: An Unusual Cause of End-Stagerenal Disease. Renal Failure, 19, 491-494.
http://dx.doi.org/10.3109/08860229709047736
[8] Laurer, D.P. and Schreiner, G.E. (1958) Bilateral Renal Cortical Necrosis. American Journal of Medicine, 24, 519-529.
http://dx.doi.org/10.1016/0002-9343(58)90292-4
[9] Kumar, R., Bansal, N., Jhorawat, R., Kimmatkar, P.D. and Malhotra, V. (2014) Renal Cortical Necrosis: A Rare Complication of Plasmodium vivax Malaria. Indian Journal of Nephrology, 24, 390-393.
http://dx.doi.org/10.4103/0971-4065.133789
[10] Hiault, C., Dequiedt, P., Benoit, O., et al. (1982) Post Partumrenal Cortical Necrosis. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 11, 839-848.
[11] Kleinknecht, D., Grünfeld, J.P., Gomez, P.C., Moreau, J.-F. and Garcia-Torres, R. (1973) Diagnostic Procedures and Long-Term Prognosis in Bilateral Renal Cortical Necrosis. Kidney International, 4, 390-400.
http://dx.doi.org/10.1038/ki.1973.135
[12] Mohandas, N. and An, X. (2012) Malaria and Human Red Blood Cells. Medical Microbiology and Immunology, 4, 593-598.
http://dx.doi.org/10.1007/s00430-012-0272-z
[13] Levi, M. (2009) Guidelines for the Diagnosis and Management of Disseminated Intravascular Coagulation. British Journal of Haematology, 145, 24-33.
http://dx.doi.org/10.1111/j.1365-2141.2009.07600.x
[14] Pruijm, M., Ponte, B., Hofmann, L., et al. (2011) New Radiological Techniques to Investigate Patients Suffering from Chronic Kidney Disease. Revue Médicale Suisse, 7, 505-509.

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.