Solventless Organic Reactive Crystallization at Mild Conditions


Solid state mixtures of two reactants, 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile, were melted at a temperature even lower than both the melting points. And dehydration condensation reaction occurred in the melt to give reaction product N-(2-cyanophenyl)-2-hydroxy-1-naphthadimine. Since the melting point of the product was higher than the reactants, self-crystallization of the product occurred. Usefulness of this one-pot synthesis and crystallization method for industrial application was described.

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Yokota, M. , Doki, N. and Akagaki, H. (2015) Solventless Organic Reactive Crystallization at Mild Conditions. Advances in Chemical Engineering and Science, 5, 461-464. doi: 10.4236/aces.2015.54047.

Conflicts of Interest

The authors declare no conflicts of interest.


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