One-Pot Three Component Domino Reaction for the Synthesis of Novel Isoxazolo[2,3-c][1,3,5]Thiadiazepin-2-Ones Catalyzed by PTSA—A Green Chemistry Approach

DOI: 10.4236/gsc.2015.53014   PDF   HTML   XML   4,283 Downloads   5,212 Views   Citations


The synthesis of novel isoxazolo[2,3-c][1,3,5]thiadiazepin-2-ones has been achieved in excellent yields by one-pot three-component Domino reaction without the production of toxic waste products by using p-toluene sulfonic acid (PTSA) as a Lewis acid catalyst. PTSA plays a crucial role in the success of the reaction, as well as for increasing reaction rate.

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Rajanarendar, E. , Venkateshwarlu, P. , Krishna, S. , Reddy, K. and Thirupathaiah, K. (2015) One-Pot Three Component Domino Reaction for the Synthesis of Novel Isoxazolo[2,3-c][1,3,5]Thiadiazepin-2-Ones Catalyzed by PTSA—A Green Chemistry Approach. Green and Sustainable Chemistry, 5, 107-114. doi: 10.4236/gsc.2015.53014.

Conflicts of Interest

The authors declare no conflicts of interest.


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