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Hepatitis B, Hepatitis C and HIV among Children 6 to 59 Months in the Community in the Democratic Republic of Congo

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DOI: 10.4236/ojped.2015.52026    2,757 Downloads   3,108 Views   Citations

ABSTRACT

Objectives: To determine the prevalence of HBV, HCV and HIV among children 6 to 59 months and determine the risk factors. Materials and Methods: Descriptive and analytical study on children aged 6 to 59 months of community Maniema (DRC) conducted between 24 June and 24 July 2013. We enrolled 781 children aged 6 to 59 months. For association between the presence of viral markers and potential risk factors the chi-square test of Pearson was applied, the odds ratios (OR) and their 95% confidence intervals (95% CIs) were calculated. The Fisher exact test was used when the conditions for application of the chi-square test of Pearson were not met. Results: The median age of the children was 34 months, 51% of female children. Ten percent of children had a history of blood transfusion; 6.6% and 64% had fever and anemia. The prevalence of HBsAg was 3.6%, the prevalence of antibodies against hepatitis C was 2.8% and HIV was 3.7%. The risk factors were HBsAg, male gender (5.5% male vs 2.0 % female; OR = 2.8(1.3 - 6.9) p = 0.001) and urban areas (5.0% rural vs 0.5% urban, OR = 0.1 (0.01 - 0.72), p = 0.01). For HCV and HIV, these factors were the history of blood transfusion in the child and the mother. For HCV 7.6% of children with blood transfusion history; OR = 3.2 (1.1 - 8.5); p = 0.05 and 11.1% history’s mother blood transfusion, OR = 5.6 (2.1 - 14.1). For HIV 11.4% of children with blood transfusion history, OR = 3.8, p = 0.005 and 9.8% history’s mother blood transfusion, OR = 2.9, p = 0.04. Conclusion: Vaccination against hepatitis B in children must be widespread, educational messages to the population must target the risk factors for these viruses. A screening of hepatitis in pregnant women must be coupled with rigorous selection policy for blood donors before each donation and qualification of any unit of blood.

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The authors declare no conflicts of interest.

Cite this paper

Kabinda, J. , Akilimali, T. , Miyanga, A. , Donnen, P. and Michèle, D. (2015) Hepatitis B, Hepatitis C and HIV among Children 6 to 59 Months in the Community in the Democratic Republic of Congo. Open Journal of Pediatrics, 5, 171-178. doi: 10.4236/ojped.2015.52026.

References

[1] Debbeche, R., Said, Y., Ben Temime, H., El Jery, K., Salem, S.B.M. and Najjar, T. (2013) Epidemiology of Hepatitis C in Tunisia. The Tunisia Medicale, 91, 86-91.
[2] Hanafiah, K.M., Groeger, J., Flaxman, D.A. and Wiersma, S.T. (2013) Global Epidemiology of Hepatitis C Virus Infection: New Estimates of Age Specific-Antibody to HCV Seroprevalence. Hepatology, 57, 1333-1342.
[3] Otta, J.J., Stevensa, G.A., Groegerb, J. and Wiersmaa, S.T. (2012) Global Epidemiology of Hepatitis B Virus Infection: New Estimates of Age-Specific and HBsAg Seroprevalence Endemicity. Vaccine, 30, 2212-2219.
http://dx.doi.org/10.1016/j.vaccine.2011.12.116
[4] Becquet, R. and Leroy, G. (2007) The Challenges Raised by the Prevention of Mother-Child Transmission of HIV in Africa. Medical Press, 36, 1947-1957.
http://dx.doi.org/10.1016/j.lpm.2007.02.031
[5] Tabone, M.D., Vaudre, G., Dehée, A. and Dollfus, C. (2005) Maternal-Fetal Transmission of HIV: Progress and Prospects. Archives of Pediatrics, 12, 1-3.
http://dx.doi.org/10.1016/j.arcped.2004.11.007
[6] Cadranel, J.F., Caron, C., Collot, G., Van Batten, C. and Dumouchel, P. (1999) Hepatitis B Epidemiology, Natural History, Biology, Treatment Monitoring. Biology Pathology, 47, 917-927.
[7] Ranger Rogez, S., Alain, S. and Denis, F. (2002) Hepatitis Viruses: MTCT. Pathology Biology, 50, 568-575.
[8] Singh, A.E., Plitt, S.S., Osiowy, C., Surynicz, K. and Kouadjo, E. (2011) Factors Associated with Vaccine Failure and Vertical Transmission of Hepatitis B among a Cohort of Mothers and Infants Canadian. Journal of Viral Hepatitis, 18, 468-473.
http://dx.doi.org/10.1111/j.1365-2893.2010.01333.x
[9] Lacaille, F. (2002) Chronic Hepatitis C in Children. Pediatrics Archive, 9, 539-542.
[10] National Plan to Combat AIDS (NSP) 2014-2017, Ministry of Health, DRC, Kinshasa 2013.
[11] Esmat, G., Hashem, M., El-Raziky, M., El-Akel, W., El-Naghy, S., El-Koofy, N., et al. (2012) Risk Factors for Hepatitis C Virus Acquisition and Predictors of Persistence among Egyptian Children. Liver International, 32, 449-456.
[12] Xeuatvongsa, A., Komada, K., Kitamura, T., Vongphrachanh, P., Pathammavong, C., Phounphenghak, K., et al. (2014) Chronic Hepatitis B Prevalence among Children and Mothers: Results from a Nationwide, Population-Based Survey in Lao People’s Democratic Republic. PLoS ONE, 9, e88829.
[13] Mao, B., Patel, M.K., Hennessey, K., Duncan, R.J., Wannemuehler, K. and Soeung, S.C. (2013) Prevalence of Chronic Hepatitis B Virus Infection after Implementation of a Hepatitis B Vaccination Program among Children in Three Provinces in Cambodia. Vaccine, 31, 4459-4464.
[14] Salama, I.I., Sami, S.M., Salama, S.I., Said, Z.N., Rabah, T.M. and Abdel-Mohsin, A.M. (2013) Hepatitis B Virus Infection among Egyptian Children Vaccinated during Infancy. International Journal of Medical, Health, Biomedical and Pharmaceutical Engineering, 7, 554-561.
[15] Compri, A.P., Miura, I., Porta, G., Lemos, M.F., Saraceni, C.P. and Moreira, R.C. (2012) Hepatitis B Virus Infection in Children, Adolescents, and Their Relatives: Genotype Distribution and Precore and Core Gene Mutations. Revista da Sociedade Brasileira de Medicina Tropical, 45, 301-304.
http://dx.doi.org/10.1590/S0037-86822012000300004
[16] Jafri, W., Jafri, N., Yakoob, J., Islam, M., Tirmizi, S.F.A., Jafar, T., et al. (2006) Hepatitis B and C: Prevalence and Risk Associated with Seropositivity Factoring among Children in Karachi, Pakistan. BMC Infectious Diseases, 6, 101.
http://dx.doi.org/10.1186/1471-2334-6-101
[17] Kelly, D. and Skidmore, S. (2002) Hepatitis C-Z: Recent Advances. Archives of Disease in Childhood, 86, 339-343.
http://dx.doi.org/10.1136/adc.86.5.339
[18] Zein, N.N. (2007) Hepatitis C in Children: Recent Advances. Current Opinion in Pediatrics, 19, 570-574.
http://dx.doi.org/10.1097/MOP.0b013e3282f04ea8
[19] Martin, S.R. (2009) Hepatitis C in Children. Pediatrics Archive, 16, 715-716.
[20] Vogt, M., Lang, T., Frosner, G., Klingler, C., Sendl, A.F., Zeller, A., et al. (1999) Prevalence and Clinical Outcome of Hepatitis C Infection in Children Who Underwent Cardiac Surgery before the Implementation of Blood-Donor Screening. New England Journal of Medicine, 341, 866-870.
http://dx.doi.org/10.1056/NEJM199909163411202
[21] El-Shabrawi, M.H. and Kamal, N.M. (2013) Burden of Pediatric Hepatitis C. World Journal of Gastroenterology, 19, 7880-7888.
http://dx.doi.org/10.3748/wjg.v19.i44.7880
[22] Nzaji, M.K. and Ilunga, B.K. (2013) A Study of the Prevalence of Infectious Markers in Blood Donors in Rural Areas. The Case of Kamina Hospital. Santé Publique, 25, 213-217.

  
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