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Phytoremedial Effect of Pleurotus cornucopiae (Oyster Mushroom) against Sodium Arsenite Induced Toxicity in Charles Foster Rats

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DOI: 10.4236/pp.2014.512120    2,870 Downloads   3,362 Views   Citations

ABSTRACT

This study was carried out to investigate the therapeutic role of the ethanolic extract of Pleurotus cornucopiae on sodium arsenite induced nephrotoxicity in rats. Sodium arsenite at the dose of 8 mg•kg–1 body weight orally caused renal damage in rats as manifested by the significant rise in serum levels of serum urea, uric acid and creatinine level compared with control. Ethanolic extracts of P. cornucopiae (400 mg•kg–1 body weight per day) was administered orally for 30 days to sodium arsenite pre-treated rats. The results show significant decrease in the serum urea, uric acid and creatinine levels in comparison to the arsenic treated denotes the nephroprotective effect of P. cornucopiae against sodium arsenite induced toxicity. Furthermore, it also possesses antioxidant effect as lipid peroxidation (MDA) levels decreased in P. cornucopiae treated group in comparison to arsenic treated group. Thus, the present study reveals that P. cornucopiae possesses nephroprotective as well as antioxidant property against arsenic induced toxicity.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Suman, S. , Ali, M. , Kumar, R. and Kumar, A. (2014) Phytoremedial Effect of Pleurotus cornucopiae (Oyster Mushroom) against Sodium Arsenite Induced Toxicity in Charles Foster Rats. Pharmacology & Pharmacy, 5, 1106-1112. doi: 10.4236/pp.2014.512120.

References

[1] Antman, K.H. (2001) Introduction: The History of Arsenic Trioxide in Cancer Therapy. The Oncologist, 6, 1-2.
http://dx.doi.org/10.1634/theoncologist.6-suppl_2-1
[2] Ahamed, S., Sengupta, M.K., Mukherjee, A., Hossain, M.A., Das, B., Nayak, B., Pal, A., Mukherjee, S.C., Pati, S., Dutta, R.N., Chatterjee, G., Mukherjee, A., Srivastava, R. and Chakraborti, D. (2006) Arsenic Groundwater Contamination and Its Health Effects in the State of Uttar Pradesh (UP) in Upper and Middle Ganga Plain, India: A Severe Danger. Science of the Total Environment, 370, 310-322.
http://dx.doi.org/10.1016/j.scitotenv.2006.06.015
[3] Mukherjee, A., Sengupta, M.K. and Hossain, M.A. (2006) Arsenic Contamination in Groundwater: A Global Perspective with Emphasis on the Asian Scenario. Journal of Health, Population, and Nutrition, 24, 142-163.
[4] Karim, M. (2000) Arsenic in Groundwater and Health Problems in Bangladesh. Water Research, 34, 304-310.
http://dx.doi.org/10.1016/S0043-1354(99)00128-1
[5] Vahter, M.E. (2007) Interactions between Arsenic Induced Toxicity and Nutrition in Early Life. Journal of Nutrition, 137, 2798-2804.
[6] Martini, F. (1989) Fundamentals of Anatomy and Physiology. Prentice Hall, Englewood Cliffs, 944.
[7] Saxena, P.N., Mahour, K. and Kumar, A. (2006) Protective Effect of Panax ginseng Extract on Renal Functions Altered by Mercuric Chloride in Albino Rats. Journal of Ginseng Research, 30, 100-105.
http://dx.doi.org/10.5142/JGR.2006.30.3.100
[8] Kumar, A., Suman, S., Kumar, R., Singh, J.K. and Ali, M. (2014) Hepatoprotective Effect of Edible Oyster Mushroom Pleurotus cornucopiae against Sodium Arsenite Induced Hepatotoxicity in Rats. International Journal of Phytomedicine, 6, 275-279.
[9] Van Herck, H., Baumans, V., Brandt, C.J., Hesp, A.P., Sturkenboom, J.H., Van Lith, H.A., Van Tintelen, G. and Beynen, A.C. (1998) Orbital Sinus Blood Sampling in Cats as Performed by Different Animal Technician: The Influence of Technique and Expertise. Laboratory Animals, 32, 377-386.
http://dx.doi.org/10.1258/002367798780599794
[10] Berthelot, M.P.E. (1859) Berthelot’s Reaction Mechanism. Report de Chimie Applique, 2884.
[11] Fawcett, J.K. and Scott, J.E. (1960) A Rapid and Precise Method for the Determination of Urea. Journal of Clinical Pathology, 13, 156-159.
http://dx.doi.org/10.1136/jcp.13.2.156
[12] Bonsnes, R.W. and Taussky, H.H. (1945) On Colorimetric Determination of Creatinine by the Jaffe Reaction. The Journal of Biological Chemistry, 158, 581-591.
[13] Toro, G. and Ackermann, P.G. (1975) Practical Clinical Chemistry. Little Brown and Co., Boston, 154.
[14] Draper, H.H. and Hadley, M. (1990) Malondialdehyde Determination as Index of Lipid Peroxidation. Methods in Enzymology, 186, 421-431.
http://dx.doi.org/10.1016/0076-6879(90)86135-I
[15] Maitani, T., Saito, N., Abe, M., Uchiyama, S. and Saito, Y. (1987). Chemical Form Dependent Induction of Hepatic Zinc-Thionein by Arsenic Administration and Effect of Co-Administered Selenium in Mice. Toxicology Letters, 39, 63-70.
http://dx.doi.org/10.1016/0378-4274(87)90257-8
[16] Peraza, M.A., Fierro, F.A., Barber, D.S., Casarez, E. and Rael, L.T. (1998) Effects of Micronutrients on Metal Toxicity. Environmental Health Perspectives, 106, 203-216.
[17] Choudhary, H., Harvey, T., Thayer, W.C., Lockwood, T.F., Stitelor, W.M., Goodrum, P.E., Hasset, J.M. and Diamond, G.L. (2001) Urinary Cadmium Elimination as a Biomarker of Exposure for Evaluating a Cadmium Dietary Exposure—Biokinetics Model. Journal of Toxicology and Environmental Health, Part A, 63, 221-250.
[18] Hollis, L., Hogstrand, C. and Wood, C.M. (2001) Tissue-Specific Cadmium Accumulation, Metallothionein Induction, and Tissue Zinc and Copper Levels during Chronic Sublethal Cadmium Exposure in Juvenile Rainbow Trout. Archives of Environmental Contamination and Toxicology, 41, 468-474.
http://dx.doi.org/10.1007/s002440010273
[19] Yoon, S., Han, S.S. and Rana, S.V.S. (2008) Molecular Markers of Heavy Metal Toxicity—A New Paradigm for Health Risk Assessment. Journal of Environmental Biology, 29, 1-14.
[20] Flora, S.J.S., Bhadauria, S., Kanan, G.M. and Singh, N. (2007) Arsenic Induced Oxidative Stress and the Role of Antioxidant Supplementation during Chelation: A Review. Journal of Environmental Biology, 28, 333-347.
[21] Farombi, E.O., Adelow, O.A. and Ajimoko, Y.R. (2007) Biomarkers of Oxidative Stress and Heavy Metal Levels as Indicators of Environmental Pollution in African Cat Fish (Clarias gariepinus) from Nigeria Ogunriver. International Journal of Environmental Research and Public Health, 4, 158-165.
http://dx.doi.org/10.3390/ijerph2007040011
[22] Anetor, J.I. (2002) Serum Uric Acid and Standardized Urinary Protein: Reliable Bioindicators of Lead Nephropathy in Nigerian Lead Workers. African Journal of Biomedical Research, 5, 19-24.
[23] Chandra Sekhar, K., Chary, N.S., Kamala, C.T., Venkatesware Rao, J., Balaram, V. and Anjaneya, Y. (2003) Risk Assessment and Pathway Study of Arsenic in Industrially Contaminated Sites of Hyderabad: A Case Study. Environment International, 29, 601-611.
http://dx.doi.org/10.1016/S0160-4120(03)00017-5
[24] Dioka, C.E., Orisakwe, O.E., Adeniyi, F.A. and Meludu, S.C. (2004) Liver and Renal Function Tests in Artisans Occupationally Exposed to Lead in Mechanic Village in Nnewi, Nigeria. International Journal of Environmental Research and Public Health, 1, 21-25.
http://dx.doi.org/10.3390/ijerph2004010021
[25] Kalia, K. and Flora, S.J.S. (2005) Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning. Journal of Occupational Health, 47, 11-21.
http://dx.doi.org/10.1539/joh.47.1
[26] Hink, H.U., Santanam, N. and Dikalov, S. (2002) Peroxidase Properties of Extracellular Superoxide Dismutase: Role of Uric Acid in Modulating in Vivo Activity. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 1402-1408.
http://dx.doi.org/10.1161/01.ATV.0000027524.86752.02
[27] Ames, B.N., Cathcart, R., Schwiers, E. and Hochst, P. (1981) Uric Acid Provides an Antioxidant Defence against and Radical Caused Aging and Cancer: A Hypothesis. Proceedings of the National Academy of Sciences of the United States of America, 78, 6858-6862.
http://dx.doi.org/10.1073/pnas.78.11.6858
[28] Aphosian, H.V. (1989) Biochemical Toxicology of Arsenic. In: Hodgson, E., Bend, J.R. and Philpot, R.M., Eds., Reviews in Biochemical Toxicology, Vol. 10, Elsevier Science Publishing Co., New York, 265-299.
[29] Klassen, C.D. (1996) Heavy Metals and Heavy Metal Antagonists. In: Hardman, J.G., Gilman, A.G. and Limbird, L.E., Eds., Goodman and Gilman’s the Pharmacological Basis of Therapeutics, McGraw-Hill, New York, 1649-1672.
[30] Verbeke, M., Van De Voorde, J. and Lameire, N. (1996) Prevention of Experimental Acute Tubular Necrosis: Current Clinical Applications and Perspectives. Advances in Nephrology from the Necker Hospital, 25, 177-216.

  
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