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The Role of Copper and Vitamin A Deficiencies Leading to Neurological Signs in Captive Cheetahs (Acinonyx jubatus) and Lions (Panthera leo) in the United Arab Emirates

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DOI: 10.4236/fns.2014.520209    4,012 Downloads   4,867 Views  

ABSTRACT

Neurological signs like ataxia and hind limb paresis have often been reported in cheetahs (Acinonyx jubatus), lions (Panthera leo) and snow leopards (Panthera unica). As a cause, copper and Vitamin A deficiencies have been discussed. Many cases were seen in cheetahs and lions in the United Arab Emirates (UAE) within the last years. The aim of this study was to find correlations between nutrition, serum, and tissue levels, focusing on copper and Vitamin A. Blood and tissue samples of affected and unaffected animals were analyzed at the Central Veterinary Research Laboratory in Dubai, UAE. Animals were split into three different groups (A, B and C) according to their diets. Minerals were determined in serum, tissue, food and water samples, and serum was additionally analyzed for Vitamin A and E. Liver, kidney and spinal cord samples were taken for histopathological investigations. Mean serum copper and liver copper levels of animals fed pure chicken muscle meat without supplements were significantly lower (0.41 ± 0.71 μM/L; 2.16 ± 0.95 ppm wet weight) than in animals fed a whole carcass prey diet (12.16 ± 3.42 μM/L; 16.01 ± 17.51 ppm wet weight) (p < 0.05). Serum Vitamin A and E levels were highest in animals fed whole carcass prey diets (1.85 ± 0.68; 27.31 ± 5.69 μM/L). Liver zinc concentrations were highest in animals fed pure chicken meat only (43.75 ± 16.48 ppm wet weight). In histopathology, demyelination of the spinal cord was found in all of the affected animals and most commonly when fed a diet based on poultry without supplements.

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Kaiser, C. , Wernery, U. , Kinne, J. , Marker, L. and Liesegang, A. (2014) The Role of Copper and Vitamin A Deficiencies Leading to Neurological Signs in Captive Cheetahs (Acinonyx jubatus) and Lions (Panthera leo) in the United Arab Emirates. Food and Nutrition Sciences, 5, 1978-1990. doi: 10.4236/fns.2014.520209.

References

[1] Jubb, K.V.F. and Huxtable, C.R. (1993) The Nervous System. In: Jubb, K.V.F., Kennedy, P.C. and Palmer, N., Eds., Pathology of Domestic Animals, 5th Edition, Vol. 1, Academic Press, New York, 360-362.
http://dx.doi.org/10.1016/B978-0-08-057133-1.50011-4
[2] Turnlund, J.R. (1994) Copper. In: Shils, M.E., Olson, J.A. and Shike, M., Eds., Modern Nutrition in Health and Disease, Vol. 8, Lea and Febiger, Philadelphia, 231-241.
[3] Watts, D.L. (1989) The Nutritional Relationships of Copper. Journal of Orthomolecular Medicine, 4, 99-108.
[4] Goodman, B.P., Chong, B.W., Patel, A.C., Fletcher, G.P. and Smith, B.E. (2006) Copper Deficiency Myeloneuropathy Resembling B12 Deficiency: Partial Resolution of MR Imaging Findings with Copper Supplementation. American Journal of Neuroradiology, 27, 2112-2114.
[5] Prodan, C.I., Holland, N.R., Wisdom, P.J., Burstein, S.A. and Bottomley, S.S. (2002) CNS Demyelination Associated with Copper Deficiency and Hyperzincemia. Neurology, 59, 1453-1456.
http://dx.doi.org/10.1212/01.WNL.0000032497.30439.F6
[6] Allan, G., Portas, T., Bryant, B., Howlett, R. and Blyde, D. (2008) Ulnar Metaphyseal Osteochondrosis in Seven Captive Bred Cheetahs (Acinonyx jubatus). Veterinary Radiology Ultrasound, 49, 551-556.
http://dx.doi.org/10.1111/j.1740-8261.2008.00430.x
[7] Allen, M.E. and Ullrey, D.E. (2004) Relationships among Nutrition and Reproduction and Relevance for Wild Animals. Zoo Biology, 23, 475-487.
http://dx.doi.org/10.1002/zoo.20029
[8] Bechert, U., Mortenson, J., Dierenfeld, E.S., Cheeke, P., Keller, M., Holick, M., Chen, T.C. and Rogers, Q. (2002) Diet Composition and Blood Values of Captive Cheetahs (Acinonyx jubatus) Fed Either Supplemented Meat or Commercial Food Preparations. Journal of Zoo and Wildlife Medicine, 33, 16-28.
[9] Bolton, L.A. and Munson, L. (1999) Glomerulosclerosis in Captive Cheetahs (Acinonyx jubatus). Veterinary Pathology, 36, 14-22.
http://dx.doi.org/10.1354/vp.36-1-14
[10] Depauw, S., Hesta, M., Whitehouse-Tedd, K., Stagegaard, J., Buyse, J. and Janssens, G.P.J. (2012) Blood Values of Adult Captive Cheetahs (Acinonyx jubatus) Fed Either Supplemented Beef or Whole Rabbit Carcasses. Zoo Biology, 31, 629-641.
http://dx.doi.org/10.1002/zoo.20427
[11] Gosselin, S.J., Setchell, K.D.R., Harrington, G.W., Welsh, M.B.B., Pylypiw, H., Kozeniauskas, R., Dollard, D., Tarr, M.J. and Dresser, B.L. (1989) Nutritional Considerations in the Pathogenesis of Hepatic Veno-Occlusive Disease in Captive Cheetahs. Zoo Biology, 8, 339-347.
http://dx.doi.org/10.1002/zoo.1430080404
[12] Palmer, A.C. and Cavanagh, J.B. (1995) Encephalo Myelopathy in Young Cats. Journal of Small Animal Practice, 36, 57-64.
http://dx.doi.org/10.1111/j.1748-5827.1995.tb02822.x
[13] Robert, N. (2008) Neurologic Disorders in Cheetahs and Snow Leopards. In: Fowler, M.E. and Miller, R.E., Eds., Zoo and Wild Animal Medicine: Current Therapy 6. Saunders Elsevier, St. Louis, 265-271.
http://dx.doi.org/10.1016/B978-141604047-7.50035-X
[14] De Risio, L., Beltran, E., Matiasek, K., de Stefani, A. and Holloway, A. (2010) Neurological Dysfunction and Caudal Fossa Overcrowding in a Young Cheetah with Hypovitaminosis A. Veterinary Record, 167, 534-536.
http://dx.doi.org/10.1136/vr.c4802
[15] Hartley, M.P., Kirberger, R.M., Haagenson, M. and Sweers, L. (2005) Diagnosis of Suspected Hypovitaminosis A Using Magnetic Resonance Imaging in African Lions (Panthera leo). Journal of the South African Veterinary Association, 76, 132-137.
http://dx.doi.org/10.4102/jsava.v76i3.414
[16] Maratea, K.A., Hooser, S.B. and Ramos-Vara, J.A. (2006) Degenerative Myelopathy and Vitamin A Deficiency in a Young Black-Maned Lion (Panthera leo). Journal of Veterinary Diagnostic Investigation, 18, 608-611.
http://dx.doi.org/10.1177/104063870601800617
[17] O’Sullivan, B.M., Mayo, F.D. and Hartley, W.J. (1977) Neurologic Lesions in Young Captive Lions Associated with Vitamin A Deficiency. Australian Veterinary Journal, 53, 187-189.
http://dx.doi.org/10.1111/j.1751-0813.1977.tb00168.x
[18] Wenker, C.J. and Robert, N. (2012) Stargazing in Lions. In: Fowler, M.E. and Miller, R.E., Eds., Zoo and Wild Animal Medicine, 7th Edition, W.B. Saunders Co., Philadelphia, 470-476.
[19] Stidworthy, M.F., Lewis, J.C.M., Penderis, J. and Palmer, A.C. (2008) Progressive Encephalo Myelopathy and Cerebellar Degeneration in a Captive-Bred Snow Leopard (Uncia uncia). Veterinary Record, 162, 522-524.
http://dx.doi.org/10.1136/vr.162.16.522
[20] Eldridge, R. (1997) LIOC Endangered Species Conservation Federation: Maintaining Mineral Balance. Newsletter, 41, 8-10.
[21] Hafner, A., Schmidt, P., H?nichen, T. and Schmahl, W. (1996) Degenerative Myelopathie bei Geparden (Acinonyx jubatus) [Degenerative Myelopathy in Cheetahs (Acinonyx jubatus)]. Berliner und Münchener tier?rztliche Wochenschrift, 109, 403.
[22] Kotsch, V., Walzer, C. and Kübber-Heiss, A. (2001) Evaluation of a Questionnaire Concerning the Cheetah Cub Ataxia within the EEP. Proceedings of 40th International Symposium on Diseases of Zoo- and Wild Animals, Rotterdam, 23-26 May 2001, 333-334.
[23] Palmer, A.C. and Franklin, R.J.M. (1999) Review of Neuropathological Material from Ataxic Cheetah Cubs at Fota Wildlife Park. Workshop on Ataxia in Cheetah Cubs, Dublin, 13-15.
[24] Palmer, A.C., Callanan, J.J., Guerin, L.A., Sheahan, B.J., Stronach, N. and Franklin, R.J. (2001) Progressive Encephalomyelopathy and Cerebellar Degeneration in 10 Captive-Bred Cheetahs. Veterinary Record, 149, 49-54.
http://dx.doi.org/10.1136/vr.149.2.49
[25] Robert, N., Walzer, C., Petit, T. and Vitaud, C. (2006) Neurological Diseases in Cheetah. Proceedings of EAZWV 6th Scientific Meeting, Budapest, 24-28 May 2006.
[26] Walzer, C. and Kübber-Heiss, A. (1995) Progressive Hind Limb Paralysis in Adult Cheetahs (Acinonyx jubatus). Journal of Zoo and Wildlife Medicine, 26, 430-435.
[27] Walzer, C., Kuebber-Heiss, A., Gelbmann, W., Suchy, A., Bauder, B. and Weissenboeck, H. (1998) Acute Hind Limb Paresis in Cheetah (Acinonyx jubatus) Cubs. Proceedings of the 2nd Scientific Meeting of the European Association of Zoo- and Wildlife Veterinarians (EAZWV), Chester, 21-24 May 1998, 267-274.
[28] Walzer, C., Url, A., Robert, N., Kübber-Heiss, A., Nowotny, N. and Schmidt, P. (2003) Idiopathic Acute Onset Myelopathy in Cheetah (Acinonyx jubatus) Cubs. Journal of Zoo and Wildlife Medicine, 34, 36-46.
[29] Zwart, P., von der Hage, M., Schotman, A.J.H., Dorrestein, G.M. and Rens, J. (1985) Copper Deficiency in Cheetah (Acinonyx jubatus). Verhandlungsbericht des 27. Internationalen Symposiums über die Erkrankungen der Zootiere, St Vincent/Torino, 9-13 June 1985, 253-257.
[30] Brand, D.J. (1980) Captive Propagation at the National Zoological Gardens of South Africa, Pretoria. International Zoo Yearbook, 20, 107-112.
[31] Shamir, M.H., Rubin, G., Aizenberg, Z., Berkovich, Z., Reifen, R., Horowitz, I., Bdolah-Abram, T. and Aroch, I. (2012) Needle Biopsy for Hepatic Vitamin A Levels in Lions (Panthera leo). Journal of Zoo and Wildlife Medicine, 43, 207- 213.
http://dx.doi.org/10.1638/2010-0038.1
[32] Schweigert, F.J., Raila, J., Wichert, B. and Kienzle, E. (2002) Cats Absorb β-Carotene, but It Is Not Converted to Vitamin A. Journal of Nutrition, 132, 1620-1612.
[33] FEDIAF (2011) Nutritional Guidelines for Complete and Complementary Pet Food for Cats and Dogs. European Pet Food Industry Federation, 17.
[34] National Research Council of the National Academies (2006) Nutrient Requirements of Dogs and Cats. The National Academic Press, Washington DC.
[35] Kölle, W. (2007) Wasseranalysen-Richtig Beurteilt [Evaluation of Water Analysis]. Wiley-VCH GmbH & Co. KGaA, Hannover.
[36] Beckmann, K.M., O’Donovan, D., McKeown, S., Wernery, U., Basu, P. and Bailey, T.A. (2013) Blood Vitamins and Trace Elements in Northern-East African Cheetahs (Acinonyx jubatus soemmeringii) in Captivity in the Middle East. Journal of Zoo and Wildlife Medicine, 44, 613-626.
http://dx.doi.org/10.1638/2011-0156R2.1
[37] Dierenfeld, E.S. (1993) Nutrition of Captive Cheetahs (Acinonyx jubatus): Food Composition and Blood Parameters. Zoo Biology, 12, 143-150.
http://dx.doi.org/10.1002/zoo.1430120113
[38] Shibly, S., Schmidt, P., Robert, N., Walzer, C. and Url, A. (2006) Immunohistochemical Screening for Viral Agents in Cheetah (Acinonyx jubatus) Myelopathy. Veterinary Record, 159, 557-561.
http://dx.doi.org/10.1136/vr.159.17.557
[39] Robert, N. and Walzer, C. (2009) Pathological Disorders in Captive Cheetahs. In: Vargas, A., Breitenmoser-Würsten, C. and Breitenmoser, U., Eds., Iberian Lynx ex Situ Conservation: An Interdisciplinary Approach, Fundación Biodiversidad, Madrid, 265-272.
[40] Doong, G., Keen, C.L., Rogers, Q., Morris, J. and Rucker, R.B. (1983) Selected Features of Copper Metabolism in the Cat. Journal of Nutrition, 113, 1963-1971.
[41] Fascetti, A.J., Rogers, Q.R. and Morris, J.G. (2000) Dietary Copper Influences Reproduction in Cats. Journal of Nutrition, 130, 1287-1290.
[42] Fowler, M.E. (1978) Metabolic Bone Disease. In: Fowler, M.E., Ed., Zoo and Wild Animal Medicine, Saunders, Philadelphia, 53-76.
[43] Phillips, J.A. (1993) Bone Consumptions by Cheetahs at Undisturbed Kills: Evidence of Lack of Focal-Palatine Erosion. Journal of Mammalogy, 74, 487-492.
http://dx.doi.org/10.2307/1382408
[44] Hendriks, W.H., Allan, F.J., Tarttelin, M.F., Collett, M.G. and Jones, B.R. (2001) Suspected Zinc-Induced Copper Deficiency in Growing Kittens Exposed to Galvanized Iron. New Zealand Veterinary Journal, 49, 68-72.
http://dx.doi.org/10.1080/00480169.2001.36205
[45] Cassidy, J.P., Caulfield, C., Jones, B.R., Worrall, S., Conlon, L., Palmer, A.C. and Kelly, J. (2007) Leukoencephalomyelopathy in Specific Pathogen-Free Cats. Veterinary Pathology, 44, 912-916.
http://dx.doi.org/10.1354/vp.44-6-912
[46] Bell, K.M. (2010) Nutrient Requirements, Utilization and Metabolism. In: Tucker, L.A. and Thomas, D.G., Eds., Spot the Difference: Are Cheetahs Really Just Big Cats? Nottingham University Press, Nottingham, 67-91.
[47] Puls, R. (1994) Mineral Levels in Animal Health. Diagnostic Data. 2nd Edition, Sherpa International, Clearbrook, 82.

  
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