Psychic Neuronal Hypersynchronies: A New Psychiatric Paradigm?

Abstract

This paper deals with certain psychic automatisms that appear suddenly in the consciousness of the subject in a passive or automatic way and that usually are diagnosed as psychiatric symptoms or manifestations of an epileptic partial seizure. These mental automatisms are described in many writings by mystics, philosophers, literates, composers, and many different great artists and creators from human history, but they did not confer any pathological value on these experiences. The analysis of the epileptogenic activity gives us arguments to propose that these automatic experiences are due to neuronal circuits physiologically adapted to fire in a hypersynchronous way. With these data we enunciate an innovative hypothesis: these psychic experiences are manifestations of an adaptive neuronal network for which we propose the term psychic hypersynchrony. Finally, we discuss the consequences of this hypothesis, especially in the epileptic, psychiatric, and neuropsychopharmacologic fields.

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Alvarez-Rodriguez, J. (2014) Psychic Neuronal Hypersynchronies: A New Psychiatric Paradigm?. Health, 6, 2089-2099. doi: 10.4236/health.2014.616242.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Temkin, O. (1971) The Falling Sickness. The Johns Hopkins University Press, Baltimore & London.
[2] Womelsdorf, T., Schoffelen, J.M., Oostenveld, R., Singer, W., Desimone, R., et al. (2007) Modulation of Neuronal Interactions through Neuronal Synchronization. Science, 316, 1609-1612.
http://dx.doi.org/10.1126/science.1139597
[3] álvarez, J. (1997) Mística y depresión: San Juan de la Cruz. Editorial Trotta, Madrid
[4] álvarez, J. (2000) éxtasis sin Fe. Editorial Trotta, Madrid.
[5] Alvarez-Silva, S., Alvarez-Rodriguez, J. and Cavanna, A.E. (2012) Epileptic Aura and Qualitative Consciousness in Focal Seizures: A Neuropsychiatric Approach. Epilepsy & Behavior, 23, 512-513.
http://dx.doi.org/10.1016/j.yebeh.2011.11.031
[6] Alvarez-Silva, S., Alvarez-Silva, I., Alvarez-Rodriguez, J., Perez-Echeverria, M.J., Campayo-Martinez, A. and Rodríguez-Fernandez, F.L. (2006) Epileptic Consciousness: Concept and Meaning of Aura. Epilepsy & Behavior, 8, 527-533.
http://dx.doi.org/10.1016/j.yebeh.2005.12.013
[7] Alvarez-Rodriguez, J., Alvarez-Silva, S. And Alvarez-Silva, I. (2005) Epilepsy and Psychiatry: Automatic Psychic Paroxysms. Medical Hypotheses, 65, 671-675.
http://dx.doi.org/10.1016/j.mehy.2005.03.030
[8] Sloviter, R.S., Bumanglag, A.V., Schwarcz, R.M. and Frotscher, M. (2012) Abnormal Dentate Gyrus Network Circuitry in Temporal Lobe Epilepsy. In: Noebels, J., Avoli, M., Rogawski, M., Olsen, R. and Delgado-Escueta, A., Eds., Jasper’s Basis Mechanisms of the Epilepsies, Oxford University Press, New York, 454-469.
[9] St. John of the Cross (1952) Dark Night of the Soul. Translated by E. Allison Peers, Chistian Classics Ethereal Library.
http://www.ccel.org/ccel/john_cross/dark_night.txt
[10] St. John of the Cross (1952) Ascent of Mount Carmel. Translated by E. Allison Peers.
http://www.ccel.org/ccel/john_cross/ascent.txt
[11] Saint Ignatius Loyola (1990) The Autobiography of St. Ignatius. Translated by J. O’Conor.
[12] Vercelletto, P. (1994) Saint Paul Disease. Ectasia and Extatic Seizures. Revue Neurologique, 150, 835-839.
[13] Meissner, W. (1994) Ignatius of Loyola: The Psychology of a Saint. Yale University Press, New Haven.
[14] García-Albea, E. (1995) Teresa de Jesús: Una ilustre epiléptica. Fundación Wellcome y Hospital Universitario Príncipe de Asturias, Alcalá de Henares.
[15] Berg, A.T., Berkovic, S.F., Brodie, M.J., Buchhalter, J., Cross, J.H., van Emde Boas, W., et al. (2010) Revised Terminology and Concepts for Organization of Seizures and Epilepsies: Report of the ILAE Commission on Classification and Terminology. Epilepsia, 51, 676-685.
http://dx.doi.org/10.1111/j.1528-1167.2010.02522.x
[16] Kinnier Wilson, S.A. (1928) Modern Problems in Neurology. Edward Arnold, London.
[17] Ey, H. (1954) études Psychiatriques. Desclée de Brouwer, Paris.
[18] Devinsky, O. and Luciano, D. (1991) Psychic Phenomena in Partial Seizures. Seminars in Neurology, 11, 100-111.
http://dx.doi.org/10.1055/s-2008-1041211
[19] Gerez, M., Sada, A. and Tello, A. (2011) Amygdalar Hyperactivity, a Fear-Related Link between Panic Disorder and Mesiotemporal Epilepsy. Clinical EEG and Neuroscience, 42, 29-39.
http://dx.doi.org/10.1177/155005941104200108
[20] Paparrigopoulos, T., Tzavellas, E., Karaiskos, D., Liappas, I. and Kyrozis, A. (2008) Left Parieto-Occipital Lesion with Epilepsy Mimicking Panic Disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2, 1606-1608.
[21] Bob, P., Jasova, D. and Raboch, J. (2011) Subclinical Epileptiform Process in Patients with Unipolar Depression and Its Indirect Psycho-physiological Manifestations. PLoS ONE, 6, 28041.
http://dx.doi.org/10.1371/journal.pone.0028041
[22] Kanner, A.M. (2008) Depression and Epilepsy: A New Perspective on Two Closely Related Disorders. Epilepsy Currents, 6, 141-146.
http://dx.doi.org/10.1111/j.1535-7511.2006.00125.x
[23] Alvarez-Silva, I., Alvarez-Rodriguez, J., Alvarez-Silva, S., Perez-Echeverria, M.J. and Campayo-Martínez, A. (2007) Melancholic Major Depression and Epilepsy. Medical Hypotheses, 69, 1046-1053.
http://dx.doi.org/10.1016/j.mehy.2007.01.088
[24] Landtblom, A.M., Lindehammar, H., Karlsson, H. and Craig, A.D. (2011) Insular Cortex Activation in Patient with Sensed Presence/Ecstatic Seizures. Epilepsy & Behavior, 20, 714-718.
http://dx.doi.org/10.1016/j.yebeh.2011.01.031
[25] Picard, F. and Craig, A.D. (2009) Ecstatic Epileptic Seizures: A Potential Window on the Neural Basis for Human Self-Awareness. Epilepsy & Behavior, 16, 539-546.
http://dx.doi.org/10.1016/j.yebeh.2009.09.013
[26] Mula, M., Marotta, A.E. and Monaco, F. (2010) Epilepsy and Bipolar Disorders. Expert Review of Neurotherapeutics, 10, 13-23.
http://dx.doi.org/10.1586/ern.09.139
[27] Mazza, M., Nicola, M., Della Marca, G., Janiri, P. and Mazza, S. (2007) Bipolar Disorder and Epilepsy: A Bidirectional Relation? Neurobiological Underpinnings, Current Hypotheses, and Future Research Directions. Neuroscientist, 13, 392-404.
http://dx.doi.org/10.1177/10738584070130041101
[28] Alvarez-Silva, I., Alvarez-Silva, S. and Alvarez-Rodriguez, J. (2010) Positive Syndrome of Schizophrenia and Epilepsy. Medical Hypotheses, 74, 294-296.
http://dx.doi.org/10.1016/j.mehy.2009.09.004
[29] Kasper, B.S., Kasper, E.M., Pauli, E. and Stefan, H. (2010) Phenomenology of Hallucinations, Illusions, and Delusions as Part of Seizure Semiology. Epilepsy & Behavior, 18, 13-23.
http://dx.doi.org/10.1016/j.yebeh.2010.03.006
[30] Elliot, B., Joyce, E. and Shorvon, S. (2009) Delusions, Illusions and Hallucinations in Epilepsy: 2. Complex Phenomena and Psychosis. Epilepsy Research, 85, 172-186.
http://dx.doi.org/10.1016/j.eplepsyres.2009.03.017
[31] St. Agustine Confessions-Book One.
http://www.ourladyswarriors.org/saints/augcon1.htm
[32] Beaumanoir, A., Gastaut, H. and Naquet, R. (1989) Reflex Seizures and Reflex Epilepsies. Editions Médicine et Hygiène, Paris.
[33] Harding, A. and Jeavons, P.M. (1994) Photosensitive Epilepsy. Mac Keith Press, London.
[34] Critchley, M. and Henson, R.A. (1977) Music and the Brain. William Heinemann Medical Books Limited, London.
[35] Proust, M. (1982) Remembrance of Things Past. Volume 1: Swann’s Way: Within a Budding Grove. Vintage Books, New York.
http://www.haverford.edu/psych/ddavis/p109g/proust.html
[36] Sengupta, A., Mahmoud, A., Tun, S.Z. and Goulding, P. (2010) Orgasm-Induced Seizures: Male Studied with Ictal Electroencephalography. Seizure, 19, 306-309.
http://dx.doi.org/10.1016/j.seizure.2010.04.007
[37] Hesse, H. (1963) Steppenwolf. Holt, Rinehart and Winston, Carls-bad.
http://img0.liveinternet.ru/images/attach/c/0/3716/3716962_hermann_hesse__steppenwolf.pdf
[38] Penman, J. and Becker, J. (2009) Religious Ecstatics, “Deep Listeners”, and Musical Emotion. Empirical Musicology Review, 4, 49-70.
[39] Juslin, P. (2005) From Mimesis to Catharsis: Expression, Perception, and Introduction of Emotion in Music. In: Miell, D., MacDonald, R. and Hargreaves, D.J., Eds., Musical Communication, Oxford University Press, New York, 85-109.
http://dx.doi.org/10.1093/acprof:oso/9780198529361.003.0005
[40] Pontius, A.A. and Wieser, H.G. (2004) Can Memories Kindle Nonconvulsive Behavioral Seizures in Humans? Case Report Exemplifying the “Limbic Psychotic Trigger Reaction”. Epilepsy & Behavior, 5, 775-783.
http://dx.doi.org/10.1016/j.yebeh.2004.05.013
[41] Schwartzkroin, P.A. (2007) Epilepsy: Models, Mechanisms and Concepts. Cambridge University Press, New York.
[42] Avoli, M. (2007) Electrophysiology and Pharmacology of Human Neocortex and Hippocampus in Vitro. In: Schwartzkroin, P.A., Ed., Epilepsy: Models, Mechanisms and Concepts, Cambridge University Press, New York, 244-280.
[43] Cain, D.P. (1989) Long-Term Potentiation and Kindling: How Similar Are the Mechanisms? Trends in Neuroscience, 12, 6-10.
http://dx.doi.org/10.1016/0166-2236(89)90146-X
[44] Baudry, M. (1986) Long-Term Potentiation and Kindling: Similar Biochemical Mechanisms? In: Delgado-Escueta, A.V., Ward, A.A, Woodbury, D.M. and Poeter, R.J., Eds., Basic Mechanisms of the Epilepsies: Molecular and Cellular Approaches, Raven Press, New York, 401-410.
[45] Ozkara, C., Ozdemir, S., Yilmaz, A., Uzan, M., Yeni, N. and Ozmen, M. (2006) Orgasm-Induced Seizures: A Study of Six Patients. Epilepsia, 47, 193-197.
http://dx.doi.org/10.1111/j.1528-1167.2006.00648.x
[46] Stevens, J. (1986) All That Spikes Is Not Fits. In: Trimble, M.R. and Reynolds, E.H., Eds., What Is Epilepsy? Churchill Livingstone, London, 97-115.
[47] Wilson, W.A. and Bragdon, A. (1993) Brain Slice Models for the Study of Seizures and Interictal Spikes. In: Schwartzkroin, P.A., Ed., Epilepsy: Models, Mechanisms and Concepts, Cambridge University Press, New York, 371-387.
http://dx.doi.org/10.1017/CBO9780511663314.015
[48] Gale, K. (1993) Focal Trigger and Pathways of Propagation in Seizure Generation. In: Schwartzkroin, P.A., Ed., Epilepsy: Models, Mechanisms and Concepts, Cambridge University Press, New York, 48-93.
[49] Uva, L., Librizzi, L., Wendling, F. and De Curtis, M. (2005) Propagation Dynamics of Epileptiform Activity Acutely Induced by Bicuculline in the Hippocampal-Parahippocampal Region of the Isolated Guinea Pig Brain. Epilepsia, 46, 1914-1925.
http://dx.doi.org/10.1111/j.1528-1167.2005.00342.x
[50] Dostoievski, F. (1992) The Idiot. Oxford University Press, New York.
http://www.online-literature.com/dostoevsky/idiot/21/
[51] Fuldford, K.W. (2011) Neuroscience and Values: A Case Study Illustrating Developments in Policy, Training and Research in the UK and Internationally. Mens Sana Monographs, 9, 79-92.
http://dx.doi.org/10.4103/0973-1229.77428
[52] Kinghorn, W.A. (2011) Whose Disorder? A Constructive MacIntyrean Critique of Psychiatric Nosology. Journal of Medicine and Philosophy, 36, 187-205.
http://dx.doi.org/10.1093/jmp/jhr006
[53] Appelbaum, P.S. (2013) Law & Psychiatry: Does the Constitution Require an Insanity Defense? Psychiatric Services, 64, 943-945.
http://dx.doi.org/10.1176/appi.ps.6401004
[54] Cascella, N.G., Schretien, D.J. and Sawa, A. (2009) Schizophrenia and Epilepsy: Is There a Shared Susceptibility? Neuroscience, 63, 227-235.
[55] Starr, M.S. (1996) The Role of Dopamine in Epilepsy. Synapse, 22, 159-194.
http://dx.doi.org/10.1002/(SICI)1098-2396(199602)22:2<159::AID-SYN8>3.0.CO;2-C
[56] Kaufman, K.R. (2012) Antiepileptic Drugs in the Treatment of Psychiatric Disorders. Epilepsy & Behavior, 21, 1-11.
http://dx.doi.org/10.1016/j.yebeh.2011.03.011
[57] álvarez, J. (2001) Neuronal Hypersynchronization, Creativity and Endogenous Psychoses. Medical Hypotheses, 56, 672-685.
http://dx.doi.org/10.1054/mehy.2000.1269
[58] Jobe, C. and Browning, R.A. (2005) The Serotonergic and Noradrenergic Effects of Antidepressant Drugs Are Anticonvulsant, Not Proconvulsant. Epilepsy & Behavior, 7, 602-619.
http://dx.doi.org/10.1016/j.yebeh.2005.07.014
[59] Sendt, K.V., Giarolly, G. and Tracy, D.K. (2012) Beyond Dopamine: Glutamate as a Target for Future Antipsychotics. ISRN Pharmacology, 2012, Article ID: 427267.
[60] Kuhn, T.S. (1962) The Structure of Scientific Revolutions. Chicago University Press, Chicago.
[61] Alvarez-Rodriguez, J. (2013) Hyperia Rating Scale.
http://www.newpsychiatry.com/article?c_art=148

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