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Influence of Surgical Technique on Overall Survival, Disease Free Interval and New Lesion Development Interval in Dogs with Mammary Tumors

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DOI: 10.4236/abcr.2014.32006    3,635 Downloads   5,411 Views   Citations

ABSTRACT

The best surgical technique for the treatment of mammary tumors in female dogs has been exhaustively debated among the scientific community. Despite biological knowledge of these tumors, some authors have suggested aggressive procedures, without any clinical advantage. The aim of this study was to evaluate the influence of surgical procedure on the overall survival, disease-free interval and new lesion development interval in dogs with mammary tumors treated according to established prognostic factors. This prospective study included 143 intact female dogs that underwent surgery for mammary neoplasms and were followed up for about 738.5 days. Each animal represented a repetition. Each surgical technique represented a group: lumpectomy (P1), mammectomy (P2), regional mastectomy without cranial abdominal gland involvement (P3), regional mastectomy with cranial abdominal gland involvement (P4), and radical mastectomy (P5). Considering only the first surgical event, 84.6% of animals had more than one mammary tumor, and tumors were identified in two mammary chains in 52.5%. There was no difference in ipsilateral and contralateral tumor development when surgical techniques were compared. Only 33 dogs developed new lesions in remaining mammary tissue, without correlation with primary lesion. Surgical technique had no effect on the overall survival, disease-free interval and new lesion development interval in patients on this study, which respected oncological surgery principles and established prognostic factors for mammary gland tumors in dogs.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Horta, R. , Lavalle, G. , Cunha, R. , Moura, L. , Araújo, R. and Cassali, G. (2014) Influence of Surgical Technique on Overall Survival, Disease Free Interval and New Lesion Development Interval in Dogs with Mammary Tumors. Advances in Breast Cancer Research, 3, 38-46. doi: 10.4236/abcr.2014.32006.

References

[1] Johnson, S.D. (1993) Reproductive Systems. In: Slatter, D., Ed., Textbook of Small Animal Surgery, 2nd Edition, Saunders Company, Philadelphia, 2177-2192.
[2] Stratmann, N., Failing, K., Richter, A. and Wehrend, A. (2008) Mammary Tumor Recurrence in Bitches after Regional Mastectomy. Veterinary Surgery, 37, 82-86. http://dx.doi.org/10.1111/j.1532-950X. 2007.00351.x
[3] Mohammed, R.A.A., Martin, S.G., Mahmmod, A.M., Macmillan, R.D., Green, A.R., Paish, E.C. and Ellis, I.O. (2011) Objective Assessment of Lymphatic and Blood Vascular Invasion in Lymph Node-Negative Breast Carcinoma: Findings from a Large Case Series with Long-Term Follow-Up. Journal of Pathology, 223, 358-365. http://dx.doi.org/10.1002/path.2810
[4] Sorenmo, K. (2003) Canine Mammary Gland Tumors. Veterinary Clinics of North America: Small Animal Practice, 33, 573-596. http://dx.doi.org/10.1016/S0195-5616(03)00020-2
[5] Sorenmo, K.U., Worley, D.R. and Goldschmidt, M.H. (2013) Tumors of the Mammary Gland. In: Withrow, S.J., Vail, D.M. and Page, R.P., Eds., Withrow and MacEwen’s Small Animal Clinical Oncology, 5th Edition, Saunders Company, Philadelphia, 538-556. http://dx.doi.org/10.1016/B978-1-4377-2362-5.00027-X
[6] Cassali, G.D., Lavalle, G.E., De Nardi, A.B., Ferreira, E., Bertagnolli, A.C., Estrela-Lima, A., et al. (2011) Consensus for the Diagnosis, Prognosis and Treatment of Canine Mammary Tumors. Brazilian Journal of Veterinary Pathology, 4, 153-180.
[7] Patsikas, M.N. and Dessiris, A. (2006) The Lymph Drainage of the Neoplastic Mammary Glands in the Bitch: A Lymphographic Study. Anatomy Histology and Embryology, 35, 228-234.
http://dx.doi.org/10.1111/j.1439-0264.2005.00664.x
[8] Pereira, C.T., Rahal, S.C., De Carvalho Balieiro, J.C. and Ribeiro, A.A. (2003) Lymphatic Drainage on Healthy and Neoplastic Mammary Glands in Female Dogs: Can It Be Really Altered? Anatomy Histology and Embryology, 32, 282-290. http://dx.doi.org/10.1046/j.1439-0264.2003.00485.x
[9] Hedlund, C.S. (2008) Cirurgia dos Sistemas Reprodutivo e Genital. In: Fossum, T.W., Hedlund, C.S., Johnson, A.L., Schulz, K.S., Seim, H.B., Willard, M.D., Bahr, A. and Carrol, G.L., Eds., Cirurgia de Pequenos Animais, 3th Edition, Elsevier, Rio de Janeiro, 702-774.
[10] Fisher, B., Montague, E., Redmond, C., Barton, B., Borland, D., Fisher, E.R., et al. (1977) Comparison of Radical Mastectomy with Alternative Treatments for Primary Breast Cancer. A First Report of Results from a Prospective Randomized Clinical Trial. Cancer, 39, 2827-2839.
http://dx.doi.org/10.1002/1097-0142(197706)39:6<2827::AID-CNCR2820390671>3.0.CO;2-I
[11] Bland, C.S. (1981) The Halsted Mastectomy: Present Illness and Past History. The Western Journal of Medicine, 134, 549-555.
[12] Fergunson, R.H. (1985) Canine Mammary Gland Tumors. Veterinary Clinics of North America: Small Animal Practice, 15, 501-511.
[13] Olson J.S. (2005) Bathsheba’s Breast: Women, Cancer & History. 1st Edition, John Hopkins University Press, Baltimore, 302 p.
[14] Cotlar, A.M., Dubose, J.J. and Rose, D.M. (2003) History of Surgery for Breast Cancer: Radical to Sublime. Current Surgery, 60, 329-337. http://dx.doi.org/10.1016/S0149-7944(02)00777-8
[15] Gilbertson, S.R., Kurzman, I.D., Zachrau, R.E., Hurvitz, A.I. and Black, M.M. (1983) Canine Mammary Epithelial Neoplasms: Biological Implications of Morphologic Characteristics Assessed in 232 Dogs. Veterinary Patholgy, 20, 127-142.
[16] Brodey, R.S., Goldschmidt, M.H. and Roszel, J.R. (1983) Canine Mammary Gland Neoplasms. Journal of American Animal Hospital Association, 19, 61-90.
[17] MacEwen, E.G., Harvey, H.J., Patnaik, A.K., Mooney, S., Hayes, A., Kurzman, I. and Hardy Jr., W.D. (1985) Evaluation of the Effect of Levamizole and Surgery on Canine Mammary Cancer. Journal of Biological Response Modifiers, 4, 418-426.
[18] Daleck, C.R., Franceschini, P.H., Alessi, A.C., Santana, A.E. and Martins, M.I.M. (1998) Aspectos Clínico e Cirúrgicos do Tumor Mamário Canino. Ciência Rural, 28, 95-100. http://dx.doi.org/10.1590/S0103-84781998000100016
[19] De Nardi, A.B., Rodaski, S., Souza, R.S., Costa, T.A., Macedo, T.R., Rodigheri, S.M., Rios, A. and Piekarz, C.H. (2002) Prevalência de Neoplasias e Modalidades de Tratamentos em C?es Atendidos no Hospital Veterinário da Universidade Federal do Paraná. Archives of Veterinay Science, 7, 15-26.
[20] Zatloukal, J., Lorenzova, J., Tichy, F., Necas, A., Kecova, H. and Kohout, P. (2005) Breed and Age Risk Factors for Canine Mammary Tumours. Acta Veterinaria Brno, 74, 103-109.
http://dx.doi.org/10.2754/avb200574010103
[21] Fowler, E.H., Wilson, G.P. and Koester, A. (1974) Biologic Behavior of Canine Mammary Neoplasms Based on a Histogenic Classification. Veterinay Pathology, 11, 212-229.
http://dx.doi.org/10.1177/030098587401100303
[22] Benjamin, S.A., Lee, A.C. and Saunders, W.J. (1999) Classification and Behavior of Canine Epithelial Neoplasms Based on Life-Span Observations in Beagles. Veterinary Pathology, 36, 423-436.
http://dx.doi.org/10.1354/vp.36-5-423
[23] Filho, J.C., Kommers, G.D., Masuda, E.K., Marques, B.M.F.P.P., Fighera, R.A., Irigoyen, L.F. and Barros, C.S.L. (2010) Estudo Retrospectivo de 1647 Tumores Mamários em C?es. Pesquisa Veterinária Brasileira, 30, 177-185. http://dx.doi.org/10.1590/S0100-736X2010000200014
[24] Salgado, B.S. and Cassali, G.D. (2012) Perspectives for Improved and More Accurate Classification of Canine Mammary Gland Neoplasms. Veterinary Pathology Online, 0, 1-2.
[25] Campos, C.B., Horta, R.S., Cobucci, G.C., Botelho, F.P.R., Lavalle, G.E. and Cassali, G.D. (2012) Abordagem Cirúrgica das Neoplasias Mamárias em Pequenos Animais: Perfil do Paciente, Comportamento e Epidemiologia Tumoral. Veterinária e Zootecnia (Suplemento), 18, 7-1.
[26] Fisher, B. (2008) Biological Research in the Evolution of Cancer Surgery: A Personal Perspective. Cancer Research, 68, 10007-10020. http://dx.doi.org/10.1158/0008-5472.CAN-08-0186

  
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