Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome

Ravi K. Ray, Muhammad A. Bashir, Sudhir Rao

Guy’s & St Thomas’ NHS Foundation Trust, London, UK.
Princess Royal University Hospital NHS Trust, Farnborough, Kent, UK.

DOI: 10.4236/ojo.2014.44017                

Abstract

We present the case of a 24-year-old man, who was a keen runner, developing chronic bilateral lower leg compartment syndrome following co-administration of Risperidone and Sodium Valproate. Having had failed medical and physical therapies, he underwent surgical decompression of his more problematic left lower leg compartments. In the interval between sequential fasciotomies, control of his psychiatric symptoms allowed the dose of his Risperidone to be reduced, resulting in a greater exercise tolerance. Ultimately he no longer required the contra-lateral lower leg compartments to be decompressed surgically. He had returned to his original level of activity with no further psychotic episodes.

Keywords

Risperidone, Compartment, Syndrome

Conflicts of Interest

The authors declare no conflicts of interest.

References

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