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Enantioselective Aldol Reactions and Michael Additions Using Proline Derivatives as Organocatalysts

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DOI: 10.4236/ijoc.2014.41008    4,422 Downloads   7,382 Views   Citations

ABSTRACT

Six compounds including five proline derivatives have been prepared and tested as chiral organocatalysts for enantioselective aldol reactions and Michael additions. The enantiomeric excesses, which are highly dependent on the molecular structure of catalysts as well as experimental conditions, have reached over 98%.

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Wagner, M. , Contie, Y. , Ferroud, C. and Revial, G. (2014) Enantioselective Aldol Reactions and Michael Additions Using Proline Derivatives as Organocatalysts. International Journal of Organic Chemistry, 4, 55-67. doi: 10.4236/ijoc.2014.41008.

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