Share This Article:

Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia

Abstract Full-Text HTML Download Download as PDF (Size:787KB) PP. 81-88
DOI: 10.4236/abb.2014.52012    3,510 Downloads   4,776 Views   Citations

ABSTRACT

The aim of this study was to determine whether 9 genetic polymorphisms confered susceptibility to schizophrenia (SCZ). The authors conducted meta-analyses on associations between SCZ and 9 variants of 6 genes including PIK3C3 (432C > T), ABCB1 (C3435T and G2677T), CTLA4 (+49A/G), OLIG2 (rs762178), GAD1 (rs1978340, rs3749034 and rs769395), and GRIN1 (G1001C). A total of 34 case-control studies were involved in our meta-analyses. Our results showed no significant association between all the loci and SCZ. This meta-analysis confirmed a lack of association of SCZ for 9 genetic polymorphisms including GRIN1 G1001C, ABCB1 C3435T and G2677T, CTLA4 + 49A/G, OLIG2 rs762178, GAD1 gene rs1978340, rs3749034 and rs769395, and PIK3C3 432C > T.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Xu, X. , Wang, L. , Liao, Q. , Xu, L. , Huang, Y. , Zhang, F. , Cheng, J. , Ye, M. , Gao, S. and Duan, S. (2014) Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia. Advances in Bioscience and Biotechnology, 5, 81-88. doi: 10.4236/abb.2014.52012.

References

[1] Fowler, T., Zammit, S., Owen, M.J. and Rasmussen, F. (2012) A population-based study of shared genetic variation between premorbid IQ and psychosis among male twin pairs and sibling pairs from Sweden. Archives of General Psychiatry, 69, 460-466.
http://dx.doi.org/10.1001/archgenpsychiatry.2011.1370
[2] van Haren, N.E., Rijsdijk, F., Schnack, H.G., et al. (2012) The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biological Psychiatry, 71, 915-921.
http://dx.doi.org/10.1016/j.biopsych.2012.01.010
[3] Sullivan, P.F., Kendler, K.S. and Neale, M.C. (2003) Schizophrenia as a complex trait: Evidence from a metaanalysis of twin studies. Archives of General Psychiatry, 60, 1187-1192.
http://dx.doi.org/10.1001/archpsyc.60.12.1187
[4] Ding, C.L., Zhou, X., Wang, B.J., Ding, M. and Pang, H. (2012) Association and its forensic significance between COMT gene and schizophrenia. Journal of Forensic Medicine, 28, 299-304.
[5] Duan, S., Gao, R., Xing, Q., et al. (2005) A family-based association study of schizophrenia with polymorphisms at three candidate genes. Neuroscience Letters, 379, 32-36.
http://dx.doi.org/10.1016/j.neulet.2004.12.040
[6] Duan, S., Yin, H., Chen, W., et al. (2005) No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study. Neuroscience Letters, 376, 93-97.
http://dx.doi.org/10.1016/j.neulet.2004.11.028
[7] Duan, S., Xu, Y., Chen, W., et al. (2004) No association between the promoter variants of tumor necrosis factor alpha (TNF-alpha) and schizophrenia in Chinese Han population. Neuroscience Letters, 366, 139-143.
http://dx.doi.org/10.1016/j.neulet.2004.05.039
[8] Sakurai, K., Toru, M., Yamakawa-Kobayashi, K. and Arinami, T. (2000) Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia. Neuroscience Letters, 296, 168-170.
http://dx.doi.org/10.1016/S0304-3940(00)01599-8
[9] Labrie, V., Wang, W., Barger, S.W., Baker, G.B. and Roder, J.C. (2010) Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice. Genes, Brain and Behavior, 9, 11-25.
http://dx.doi.org/10.1111/j.1601-183X.2009.00529.x
[10] Jovanovic, N., Bozina, N., Lovric, M., Medved, V., Jakovljevic, M. and Peles, A.M. (2010) The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naive patients with first-episode schizophrenia treated with risperidone. European Journal of Clinical Pharmacology, 66, 1109-1117.
http://dx.doi.org/10.1007/s00228-010-0850-1
[11] Nikisch, G., Baumann, P., Oneda, B., et al. (2011) Cytochrome P450 and ABCB1 genetics: Association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study. Journal of Psychopharmacology, 25, 896-907.
http://dx.doi.org/10.1177/0269881110389208
[12] Kuzman, M.R., Medved, V., Bozina, N., Grubisin, J., Jovanovic, N. and Sertic, J. (2011) Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia. Pharmacogenomics Journal, 11, 35-44. http://dx.doi.org/10.1038/tpj.2010.7
[13] Singh, B., Bera, N.K., Nayak, C.R. and Chaudhuri, T.K. (2011) Immunomodulation in schizophrenia: A study among the Indian schizophrenia patients of Siliguri, West Bengal. Asian Journal of Psychiatry, 4, 277-283.
http://dx.doi.org/10.1016/j.ajp.2011.08.002
[14] Li, Y., Zhou, K., Zhang, Z., et al. (2012) Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: Evidence for the immune hypothesis of schizophrenia. Molecular BioSystems, 8, 2664-2671.
http://dx.doi.org/10.1039/c2mb25158b
[15] Michel, M., Schmidt, M.J. and Mirnics, K. (2012) Immune system gene dysregulation in autism and schizophrenia. Developmental Neurobiology, 72, 1277-1287.
http://dx.doi.org/10.1002/dneu.22044
[16] Liu, J., Li, J., Li, T., et al. (2011) CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population. Brain, Behavior, and Immunity, 25, 429-433.
http://dx.doi.org/10.1016/j.bbi.2010.10.024
[17] Jones, A.L., Holliday, E.G., Mowry, B.J., et al. (2009) CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia. Brain, Behavior, and Immunity, 23, 347-350.
http://dx.doi.org/10.1016/j.bbi.2008.09.008
[18] Jun, T.Y., Pae, C.U., Chae, J.H., Bahk, W.M., Kim, K.S. and Han, H. (2002) Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population. Psychiatry Research, 110, 19-25. http://dx.doi.org/10.1016/S0165-1781(02)00031-8
[19] Blum, B.P. and Mann, J.J. (2002) The GABAergic system in schizophrenia. International Journal of Neuropsychopharmacology, 5, 159-179.
http://dx.doi.org/10.1017/S1461145702002894
[20] Katsel, P., Davis, K.L. and Haroutunian, V. (2005) Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: A gene ontology study. Schizophrenia Research, 79, 157-173. http://dx.doi.org/10.1016/j.schres.2005.06.007
[21] Sims, R., Hollingworth, P., Moskvina, V., et al. (2009) Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. Neuroscience Letters, 461, 54-59.
http://dx.doi.org/10.1016/j.neulet.2009.05.051
[22] Schurman, S.H., Sharon, N., Goldschmidt, R.A. and Scanlon, E.F. (1990) Improved detection of metastases to lymph nodes and estrogen receptor determination. Archives of Surgery, 125, 179-182.
http://dx.doi.org/10.1001/archsurg.1990.01410140057010
[23] Fruman, D.A., Meyers, R.E. and Cantley, L.C. (1998) Phosphoinositide kinases. Annual Review of Biochemistry, 67, 481-507.
http://dx.doi.org/10.1146/annurev.biochem.67.1.481
[24] Wang, L., Budolfson, K. and Wang, F. (2011) Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. Neuroscience, 172, 427-442.
http://dx.doi.org/10.1016/j.neuroscience.2010.10.035
[25] Tang, R., Zhao, X., Fang, C., et al. (2008) Investigation of variants in the promoter region of PIK3C3 in schizophrenia. Neuroscience Letters, 437, 42-44.
http://dx.doi.org/10.1016/j.neulet.2008.03.043
[26] Coory, M.D. (2010) Comment on: Heterogeneity in metaanalysis should be expected and appropriately quantified. International Journal of Epidemiology, 39, 932.
http://dx.doi.org/10.1093/ije/dyp157
[27] Ishii, T., Moriyoshi, K., Sugihara, H., et al. (1993) Molecular characterization of the family of the N-methyl-Daspartate receptor subunits. Journal of Biological Chemistry, 268, 2836-2843.
[28] Monyer, H., Sprengel, R., Schoepfer, R., et al. (1992) Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science, 256, 1217-1221.
http://dx.doi.org/10.1126/science.256.5060.1217
[29] Mohn, A.R., Gainetdinov, R.R., Caron, M.G. and Koller, B.H. (1999) Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell, 98, 427-436. http://dx.doi.org/10.1016/S0092-8674(00)81972-8
[30] Zarain-Herzberg, A., Lee-Rivera, I., Rodriguez, G. and Lopez-Colome, A.M. (2005) Cloning and characterization of the chick NMDA receptor subunit-1 gene. Molecular Brain Research, 137, 235-251.
http://dx.doi.org/10.1016/j.molbrainres.2005.03.006
[31] Qin, S., Zhao, X., Pan, Y., et al. (2005) An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. European Journal of Human Genetics, 13, 807-814.
http://dx.doi.org/10.1038/sj.ejhg.5201418
[32] Guerrini, L., Blasi, F. and Denis-Donini, S. (1995) Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro. Proceedings of the National Academy of Sciences of USA, 92, 9077-9081.
http://dx.doi.org/10.1073/pnas.92.20.9077
[33] O’Mahony, A., Raber, J., Montano, M., et al. (2006) NFkappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity. Molecular and Cellular Biology, 26, 7283-7298.
http://dx.doi.org/10.1128/MCB.00510-06
[34] Liu, A., Hoffman, P.W., Lu, W. and Bai, G. (2004) NFkappaB site interacts with Sp factors and up-regulates the NR1 promoter during neuronal differentiation. Journal of Biological Chemistry, 279, 17449-17458.
http://dx.doi.org/10.1074/jbc.M311267200

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.