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Nootropic Activity of Caralluma fimbriata Extract in Mice

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DOI: 10.4236/fns.2014.52019    3,631 Downloads   5,017 Views   Citations

ABSTRACT

We investigated the effects of a standardized extract of Caralluma fimbriata Wall (CFE) on learning and memory in mice using various behavioural models. Unusually, CFE exerts both nootropic and anxiolytic effects.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

R. Rajendran, D. Ambikar, R. Khandare, V. Sannapuri, N. Vyawahare and P. Clayton, "Nootropic Activity of Caralluma fimbriata Extract in Mice," Food and Nutrition Sciences, Vol. 5 No. 2, 2014, pp. 147-152. doi: 10.4236/fns.2014.52019.

References

[1] C. J. Vas, C. Pinto, D. Panniker, N. Deshpande, L. Kulkarni and S. Sachadeva, “Prevalence of Dementia in an Urban Indian Population,” International Psychogeriatrics, Vol. 13, No. 4, 2001, pp. 439-450.
http://dx.doi.org/10.1017/S1041610201007852
[2] T. E. Andreoli, C. C. J. Carpenter, J. C. Bennett and F. Plum, “Cecil Essentials of Medicine,” 4th Edition, Saunders WB Co., Philadelphia, 2002, pp. 799-802.
[3] S. A. Beaudreau and R. O’Hara, “Late Life Anxiety and Cognitive Impairment: A Review,” American Journal of Geriatric Psychiatry, Vol. 16, No. 10, 2008, pp. 790-803.
http://dx.doi.org/10.1097/JGP.0b013e31817945c3
[4] V. Ravichandra, A. Devi, S. Adiga and K. S. Rai, “Evaluation of the Effect of Glycerriza glabra Linn Root Extract on Spatial Learning and Passive Avoidance Response in Mice,” Indian Drug, Vol. 44, No. 3, 2007, pp. 214-219.
[5] A. D. Tarnalli and T. C. Cheeramkuzhy, “Influence of Clitoria Ternatea Extracts on Memory and Central Cholinergic Activity in Rats,” Pharmaceutical Biology, Vol. 38, No. 1, 2000, pp. 51-56.
[6] H. K. Singh and B. N. Dhavan, “Neuropharmacological Effect of Ayurvedic nootropic Baccopa monniera Linn,” Indian Journal of Pharmacology, Vol. 29, No. 5, 1997, pp. 259-265.
[7] J. N. Dhuley, “Nootropic Like Effect of Ashwagandha (Withania somniferra) in Mice,” Phytotherapy Research, Vol. 15, No. 6, 2001, pp. 524-528.
http://dx.doi.org/10.1002/ptr.874
[8] K. Nalini, K. S. Karanth, A. Rao and A. R. Aroor, “Effects of Celastrus paniculatus on Passive Avoidance Performance and Biogenic Amine Turnover in Albino Rats,” Journal of Ethnopharmacology, Vol. 47, No. 2, 1995, pp. 101-108. http://dx.doi.org/10.1016/0378-8741(95)01264-E
[9] Y. Yamaguchi, M. Higashi and H. Kobayashi, “Effect of Ginsennosides on Impaired Performance Caused by Scopolamines in Rats,” European Journal of Pharmacology, Vol. 312, 1996, pp. 149-151.
http://dx.doi.org/10.1016/0014-2999(96)00597-3
[10] A. Das, G. Shanker, N. Chandishwar, R. Pal, S. Singh and H. K. Singh, “A Comparative Study in Rodents of Standardized Extracts of Bacopa monniera and Ginko Biloba Anticholinesterase and Cognitive Enhancing Activities,” Pharmacology Biochemistry & Behavior, Vol. 73, No. 4, 2002, pp. 893-900.
http://dx.doi.org/10.1016/S0091-3057(02)00940-1
[11] K. Kishore and N. Singh, “Effect of Bacosides, Alcoholic Extract of Bacopa monniera Linn (Brahmi), on Experimental Amnesis in Mice,” Indian Journal of Experimental Biology, Vol. 43, No. 7, 2005, pp. 640-645.
[12] A. Bader, A. Braca, N. De Tommasi and I. Morelli, “Further Constituents from Caralluma Negevensis,” Phytochemistry, Vol. 62, 2003, pp. 1277-1281.
http://dx.doi.org/10.1016/S0031-9422(02)00678-7
[13] E. Aguirre-Hernández, M. E. González-Trujano, A. L. Martínez, J. Moreno, G. Kite, T. Terrazas and M. Soto-Hernández, “HPLC/MS Analysis and Anxiolytic-Like Effect of Quercetin and Kaempferol Flavonoids from Tilia Americana var. Mexicana,” Journal of Ethnopharmacology, Vol. 127, No. 1, 2010, pp. 91-97.
http://dx.doi.org/10.1016/j.jep.2009.09.044
[14] Y. Hou, M. A. Aboukhatwa, D. L. Lei, K. Manaye, I. Khan and Y. Luo, “Anti-Depressant Natural Flavonols Modulate BDNF and Beta Amyloid in Neurons and Hippocampus of Double TgAD Mice,” Neuropharmacology, Vol. 58, No. 6, 2010, pp. 911-920.
http://dx.doi.org/10.1016/j.neuropharm.2009.11.002
[15] L. Ren, F. Wang, Z. Xu, W. M. Chan, C. Zhao and H. Xue, “GABA(A) Receptor Subtype Selectivity Underlying Anxiolytic Effect of 6-Hydroxyflavone,” Biochemical Pharmacology, Vol. 79, No. 9, 2010, pp. 1337-1344.
http://dx.doi.org/10.1016/j.bcp.2009.12.024
[16] M. Lader and S. Morton, “Benzodiazepine Problems,” British Journal of Addiction, Vol. 86, No. 7, 1991, pp. 823828. http://dx.doi.org/10.1111/j.1360-0443.1991.tb01831.x
[17] R. G. Lister, “The Use of Plus Maze to Measure Anxiety in Mouse,” Psychopharmacology, Vol. 92, No. 2, 1987, pp. 180-185. http://dx.doi.org/10.1007/BF00177912
[18] P. Quinette, B. Gaillery, B. Desgranges, V. Sayette, F. Vaider and F. Eustache, “Working Memory and Executive Function in Transient Global Amnesia,” Brain, Vol. 126, 2003, pp. 1917-1934.
http://dx.doi.org/10.1093/brain/awg201
[19] G. Achliya, U. Barbade, S. Wadodkar and A. Dorle, “Effect of Brahmi Ghrita, a Polyherbal Formulation on Learning and Memory Paradigms in Experimental Animals,” Indian Journal of Pharmacology, Vol. 36, No. 3, 2004, pp. 159-162.
[20] H. G. Vogel and W. H. Vogel, “Drug Discovery and Evaluation: Pharmacological Assays,” 2nd Edition, Springer Ver Lag Berlin Heidelberg, New York, 2002, pp. 435436. http://dx.doi.org/10.1007/3-540-29837-1
[21] S. D. Iversen and S. H. Synder, Eds., “Handbook of Psychopharmacology,” Vol. 20, Plenum Press, New York, 1988, pp. 437-445.
[22] M. W. Brown and J. P. Aggelton, “Episodic Memory, Amnesia and the Hippocampalanterior Thalamic Axis,” Journal of Behavioral and Brain Science, Vol. 22, No. 4, 1998, pp. 425-444.
[23] M. Parle, D. Dhingra and S. K. Kulkarni, “Neurochemical Basis of Learning and Memory,” Indian Journal of Pharmaceutical Sciences, Vol. 66, No. 4, 2004, pp. 371-376.
[24] A. D. Baddeley, “Working Memory,” Science, Vol. 255, No. 5044, 1992, pp. 556-559.
http://dx.doi.org/10.1126/science.1736359
[25] J. F. Cryan and I. Lucki, “Antidepressant Like Behavioral Effects Mediated by 5-Hydroxytryptamine2c Receptors,” Journal of Pharmacology and Experimental Therapeutics, Vol. 295, No. 3, 2000, pp. 1120-1126.
[26] Y. Pan, F. M. Wang, L. Q. Qiang, D. M. Zhang and L. D. Kong, “Icariin Attenuates Chronic Mild Stress-Induced Dysregulation of the LHPA Stress Circuit in Rats,” Psychoneuroendocrinology, Vol. 35, No. 2, 2010, pp. 272283. http://dx.doi.org/10.1016/j.psyneuen.2009.06.020
[27] S. Pellow, P. Chopin, S. E. File and M. Briley, “Validation of Open: Closed Arm Entries in an Elevated Plus Maze as a Measure of Anxiety in Rats,” Journal of Neuroscience Methods, Vol. 14, 1985, pp. 149-167.
http://dx.doi.org/10.1016/0165-0270(85)90031-7
[28] R. Kumar, D. S. Mac and W. F. Gabrielli, “Anxiolytics and Memory: A Comparison of Lorazepam and Alprazolam,” Journal of Clinical Psychiatry, Vol. 48, No. 4, 1987, pp. 158-160.
[29] R. L. Smith and R. J. Barrett, “Tolerance to the Anticonflict Effects of Diazepam: Importance of Methodological Considerations,” Pharmacology Biochemistry & Behavior, Vol. 58, 1997, pp. 61-66.
http://dx.doi.org/10.1016/S0091-3057(96)00460-1
[30] P. P. Roy-Byrne, “The GABA-Benzodiazepine Receptor Complex: Structure, Function, and Role in Anxiety,” Journal of Clinical Psychiatry, Vol. 66, Suppl. 2, 2005, pp. 14-20.
[31] R. Kuriyan, T. Raj, S. K. Srinivas, V. Mario, R. Rajendran and A. V. Kurpad, “Effect of Caralluma fimbriata Extract on Appetite, Food Intake and Anthropometry in Adult Indian Men and Women,” Appetite, Vol. 48, No. 3, 2007, pp. 338-344.
http://dx.doi.org/10.1016/j.appet.2006.09.013
[32] S. Kamalakannan, R. Rajendran, R. Venkatesh, P. Clayton and A. K. Akbarsha, “Anti-Obesegenic and Anti-Atherosclerotic Properties of Caralluma fimbriata Extract,” Journal of Nutrition and Metabolism, 2011, Article ID: 285301.

  
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