A Pilot Survey of Mercury in Drugs, Cosmetics and Household Products Using Reliable Analytical Methods

DOI: 10.4236/jcdsa.2013.34039   PDF   HTML     3,874 Downloads   7,210 Views   Citations


The concentration of mercury (Hg) was accurately determined in more than 228 drugs, cosmetics and household products manufactured in a variety of countries. Some drugs were found to contain up to 4424 ppb Hg, and some skin creams contained up to 2769 ppm Hg. Hg in skin creams was found to be almost 100% elemental Hg (Hg0), a volatile species of Hg. Hg0 can enter the human body through inhalation and skin absorption, potentially resulting in the serious consequence of mercury poisoning. The mercury can also volatilize, contaminating the surrounding air. Other people, for example, infants and children, who are close to or contacting the skin of the person using the cosmetics, can also absorb the mercury. Total mercury (THg) was determined by combustion/trap/CVAFS. Methyl mercury (MeHg) and inorganic mercury (Hg2+) were determined by the ethylation based method. The emission of Hg0 was determined by evaporation/trap/CVAFS. All analyses were performed in accordance with explicit quality assurance and quality control protocols and procedures.

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L. Liang, J. Gilkeson, E. Swain, E. Bennett, M. Li, M. Deng and P. Pang, "A Pilot Survey of Mercury in Drugs, Cosmetics and Household Products Using Reliable Analytical Methods," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 3 No. 4, 2013, pp. 256-262. doi: 10.4236/jcdsa.2013.34039.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] T. W. Clarkson and L. Magos, “The Toxicology of Mercury and Its Chemical Compounds,” Critical Reviews in Toxicology, Vol. 36, No. 8, 2006, pp. 609-662. http://dx.doi.org/10.1080/10408440 600845619
[2] M. Horvat, “Determination of Mercury and Its Compounds in Water, Sediment, Soil and Biological Samples,” In: N. Pirrone and K. R. Mahaffey, Eds., Dynamics of Mercury Pollution on Regional and Global Scales: Atmospheric Processes and Human Exposures around the World, Springer, New York, 2005. pp 154-190. http://dx.doi.org/10.1007/0-387-24494-8_8
[3] T. Barkay and I. Wagner-Dobler, “Microbial Transformations of Mercury: Potentials, Challenges, and Achievements in Controlling Mercury Toxicity in the Environment,” In: A. I. Laskin, J. W. Bennett and G. M. Gadd, Eds., Advances in Applied Microbiology, Elsevier Academic Press Inc., San Diego, 2005, pp. 1-52.
[4] California Department of Public Health, “Health Alert: Mercury Poisoning Linked to Use of Face Lightening Cream,” California Health and Human Services Agency, Department of Public Health, Sacramento, 2010.
[5] E. B. Swain, P. M. Jakus, G. Rice, F. Lupi, P. A. Maxson, J. M. Pacyna, A. Penn, S. J. Spiegel and M. M. Veiga, “Socioeconomic Consequences of Mercury Use and Pollution,” Ambio, Vol. 36, No. 1, 2007, pp. 45-61. http://dx.doi.org/10.1579/0044-7447(2007)36[45:SCOMUA]2.0.CO;2
[6] USFDA, “Mercury in Drug and Biologic Products,” FDA.gov Food and Drug Administration, 13 June 2006. http://www.fda.gov/RegulatoryInformation/Legislation/FederalFoodDrugandCosmeticActFDC Act/SignificantAmendmentstotheFDCAct/FDAMA/ucm100218.htm
[7] USFDA, “Mercury Poisoning Linked to Skin Products,” 6 March 2012. http://www.fda.gov/For Consumers/ConsumerUpdates/ucm294849.htm
[8] WHO, “Mercury in Skin Lightening Creams,” World Health Organization, 2011.
[9] USFDA, “Use of Mercury Compounds in Cosmetics Including Use as Skin Bleaching Agents in Cosmetic Preparations Also Regarded as Drugs,” 21 CFR 700.13.
[10] Minnesota Department of Health, “Skin-Lightening Products Found to Contain Mercury,” 9 March 2012. http://www.health.state.mn.us/topics/skin/
[11] L. Liang, M. Horvat and P. Danilchik, “Novel Analytical Methods for Determination of Low Level of Total Mercury in Petroleum and Its Products by Gold Amalgamation CVAFS,” 4th International Conference on Mercury as a Global Pollutant, Hamburg, 4-8 August 1996.
[12] L. Liang, M. Horvat and P. Danilchik, “A Novel Analytical Method for Determination of Picogram Levels of Mercury in Petroleum Based Products,” The Science of the Total Environment, Vol. 187, No. 1, 1996, pp. 57-64. http://dx.doi.org/10.1016/0048-9697(96)05129-7
[13] L. Liang, S. Lazoff, E. Swain, J. Gilkeson and M. Horvat, “Determination of Mercury in Crude Oil by In-Situ Thermal Decomposition Using a Simple Lab Built System,” Fresenius Journal of Analytical Chemistry, Vol. 367, No. 1, 2000, pp. 8-11. http://dx.doi.org/10.1007/s002160051590
[14] S. M. Wilhelm, L. Liang and D. Kirchgessner, “Identification and Properties of Mercury Species in Crude Oil,” Energy and Fuels, Vol. 20, No. 1, 2006, pp. 180-186. http://dx.doi.org/10.1021/ef 0501391
[15] S. M. Wilhelm, L. Liang, D. Cussen and D. Kirchgessner, “Mercury in Crude Oil Processed in the United States (2004),” Environmental Science and Technology, Vol. 41, No. 13, 2007, pp. 4509-4514. http://dx.doi.org/10.1021/es062742j
[16] L. Liang, M. Horvat, V. Fajon, N. Prosenc, H. Li and P. Pang, “Comparison of Improved Combustion/Trap Technique to Wet Extraction Methods for Determination of Mercury in Crude Oil and Related Products by Atomic Fluorescence,” Energy & Fuels, Vol. 17, No. 5, 2003. pp. 1175-1179. http://dx.doi.org/10.1021/ef030042j
[17] L. Liang, S. M. Wilhelm and P. Pang, “Occurrence of Dimethylmercury ((CH3)2Hg) in Organic Solvents,” Materials and Geoenvironment, Vol. 51, No. 2, 2004, pp. 1968-1971.
[18] US EPA, “Method 1631, Mercury in Water by Oxidation, Purge and Trap, and Cold Vapor Atomic Fluorescence Spectrometry,” Environmental Protection Agency, Washington DC, 2002.
[19] L. Liang, M. Horvat and N. S. Bloom, “An Improved Speciation Method for Mercury by GC/CVAFS after Aqueous Phase Ethylation and Room Temperature Precollection,” Talanta, Vol. 41, No. 3, 1994, pp. 371-379. http://dx.doi.org/10.1016/0039-9140(94)80141-X
[20] L. Liang, N. S. Bloom and M. Horvat, “Simultaneous Determination of Mercury Speciation in Biological Materials by GC/CVAFS after Ethylation and Room Temperature Precollection,” Clinical Chemistry, Vol. 40, No. 4, 1994, pp. 602-607.
[21] L. Liang, M. Horvat, J. Alvarez, L. Young, J. Kotnik and L. Zhang, “The Challenge and Its Solution When Determining Biogeochemically Reactive Inorganic Mercury (RHg): Getting the Analytical Method Right,” American Journal of Analytical Chemistry, Vol. 4 No. 11, 2013, pp. 623-632.
[22] L. Liang and N. S. Bloom, “Determination of Total Mercury by Single-Stage Gold Amalgamation with Cold Vapor Atomic Spectrometry,” Journal of Analytical Atomic Spectrometry, Vol. 8, 1993, pp. 591-594 http://dx.doi.org/10.1039/ja9930800591
[23] USFDA, “Drug Products Containing Certain Active Ingredients Offered Over-The-Counter (OTC) for Certain Uses,” 21 CFR 310.545, 1998.

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