Preparation of Temperature and Water Responsive Microcapsules Containing Hydroquinone with Spray Drying Method


It was tried to prepare temperature and water responsive microcapsules containing hydroquinone as a water soluble core material with the spray drying method. Microcapsules were composed of ethyl cellulose (EC), methyl cellulose (MC) and P-N-isopropylacrylamid (PNIPAM). P-N-isopropylacrylamid and methyl cellulose were used as a temperature responsive polymer and as a water responsive polymer, respectively. Ethyl cellulose was the main shell material of microcapsule. At the microencapsulation process, the core and shell materials were dissolved in ethyl alcohol dissolving water (20 wt%) and then, spray-dried to prepare microcapsules. In the fundamental operation, the concentration and molecular weight of methyl cellulose were mainly changed. The releasing rate of hydroquinone was repressed at 40°C and increased at 20°C due to temperature responsive PNIPAM. Furthermore, responsibility to water was increased with the concentration of methyl cellulose.

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K. Shirokawa, Y. Taguchi, H. Yokoyama, F. Ono and M. Tanaka, "Preparation of Temperature and Water Responsive Microcapsules Containing Hydroquinone with Spray Drying Method," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 3 No. 3B, 2013, pp. 49-54. doi: 10.4236/jcdsa.2013.33A2012.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] H. Dou and M. Jiang, “Fabrication, Characterization and Drug Loading of pH-Dependent Multi-Morphological Nanoparticles Based on Cellulose,” Polymer International, Vol. 56, No. 10, 2007, pp. 1206-1212.
[2] S. Ekici and D. Saraydin, “Interpenetrating Polymeric Network Hydrogels for Potential Gastrointestinal Drug Release,” Polymer International, Vol. 56, No. 11, 2007, pp. 1371-1377. 1002/pi.2271
[3] P. V. Kulkarni, J. Keshavayya and V. H. Kulkarni, “Effect of Method of Preparation and Process Variables on Controlled Release of Insoluble Drug from Chitosan Microspheres,” Polymers for Advanced Technologies, Vol. 18, No. 10, 2007, pp. 814-821.
[4] B. L. Guo, J. F. Yuan and Q. Y. Gao, “pH and Ionic Sensitive Chitosan/Carboxymethyl Chitosan IPN Complex Films for the Controlled Release of Coenzyme A,” Colloid and Polymer Science, Vol. 286, No. 2, 2008, pp. 175-181.
[5] J. T. Zhang, X. L. Liu, A. Fahr and K. D. Jandt, “A New Strategy to Prepare Temperature-Sensitive Poly(N-isopropylacrylamide) Microgels,” Colloid and Polymer Science, Vol. 286, No. 10, 2008, pp. 1209-1213.
[6] G. C. Kim, Y. Y. Li, Y. F. Chu, S. X. Cheng, R. X. Zhuo and X. Z. Zhang, “Nanosized Temperature-Responsive Fe3O4-UA-g-P(UA-co-NIPAAm) Magnetomicelles for Controlled Drug Release,” European Polymer Journal, Vol. 44, No. 9, 2008, pp. 2761-2767. 07.015
[7] B. L. Guo, J. F. Yuan and Q. Y. Gao, “Preparation and Release Behavior of Temperatureand pH-Responsive Chitosan Material,” Polymer International, Vol. 57, No. 3, 2008, pp. 463-468.
[8] Y. Zhou, D. Yang, G. Ma, H. Tan, Y. Jin and J. Nie, “A pH-Sensitive Water-Soluble N-Carboxyethyl Chitosan/ Poly(hydroxyethyl methacrylate) Hydrogel as a Potential Drug Sustained Release Matrix Prepared by Photopolymerization Technique,” Polymers for Advanced Technologies, Vol. 19, No.8, 2008, pp. 1133-1141.
[9] H. Feng, Y. Zhao, M. Pelletier, Y. Dan and Y. Zhao, “Synthesis of Photoand pH-Responsive Composite Nanoparticles Using a Two-Step Controlled Radical Polymerization Method,” Polymer, Vol. 50, No. 15, 2009, pp. 3470-3477.
[10] M. Tanaka, “Key Point of Preparation of Nano/Microcapsules,” Techno System Publishing Co. Ltd., Tokyo, 2008.
[11] A. Soottitantawat, F. Bigeard, H. Uoshii, T. Furuta, A. Ohkawara and P. Linko, “Influence of Emulsion and Powder Size on the Stability of Encapsulated D-Limonene by Spray Drying,” Innovative Food Science and Emerging Technologies, Vol. 6, No. 1, 2005, pp. 107-114. 1016/j.ifset.2004.09.003
[12] S. Polavarapu, C. M. Oliver, S. Ajlouni and M. A. Augustin, “Impact of Extra Virgin Olive Oil and Ethylenediaminetetraacetic Acid (EDTA) on the Oxidative Stability of Fish Oil Emulsions and Spray-Dried Microcapsules Stabilized by Sugar Beet Pectin,” Journal of Agricultural and Food Chemistry, Vol. 60, No. 1, 2012, pp. 444-450.
[13] K. Laohasongkram, T. Mahamaktudsanee and S. Chaiwanichsiri, “Microencapsulation of Macadamia Oil by Spray Drying,” Procedia Food Science, Vol. 1, 2011, pp. 1660-1665. 1016/j profoo.2011.09.245
[14] A. Gharsallaoui, G. Roudaut, L. Beney, O. Chambin, A. Voilley and R. Saurel, “Properties of Spray-Dried Food Flavours Microencapsulated with Two-Layered Membranes: Roles of Interfacial Interactions and Water,” Food Chemistry, Vol. 132, No. 4, 2012, pp. 1713-1720. 1016/j.foodchem.2011.03.028

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