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The Expression of NF-κB in the Glomerulus of Hyperlipidemia Rats

DOI: 10.4236/ijcm.2011.21001    4,057 Downloads   7,177 Views  


Background: The present study was to explore the underlying mechanism of the nuclear factor-kappa B (NF-κB) and the level of monocyte chemoattractant protein-1 (MCP-1) in hyperlipidemia rats. Methods: Rats were given with high fat diet and vitamin D3 by intragastric administration. After four weeks, the level of the plasma cholesterol, low density lipoprotein cholesterol (LDLC), MCP-1 and NF-κB were detected by immunohistochemical method and enzyme linked immunosorbent assay (ELISA). Results: The levels of the plasma cholesterol and LDLC were higher than that of the control group. A significant in-crease for the expressions of MCP-1 and NF-κB was observed. Conclusion: This indi-cated that the activation of NF-κB could play a crucial role in glomerulus of hyperlipidemia rats.

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The authors declare no conflicts of interest.

Cite this paper

X. Li, R. Yan and J. Peng, "The Expression of NF-κB in the Glomerulus of Hyperlipidemia Rats," International Journal of Clinical Medicine, Vol. 2 No. 1, 2011, pp. 1-4. doi: 10.4236/ijcm.2011.21001.


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