Antiphospholipid antibody syndrome and pregnancy

Abstract

Recurrent foetal loss in early and late stages of pregnancy is a common problem of women affected by anti-phospholipid antibody syndrome. The therapeutic scheme consisting of associating aspirin and heparin has shown an improvement of the prognosis for the next pregnancies. We report 3 cases of anti-phospholipid antibody syndrome and pregnancy, and we underline the clinical, therapeutic and prognosis features of this syndrome.

Share and Cite:

Errarhay, S. , Hmidani, N. , Mahmoud, S. , Labib, L. , Saadi, H. , Hrandou, M. , Bouchikhi, C. and Banani, A. (2013) Antiphospholipid antibody syndrome and pregnancy. Open Journal of Obstetrics and Gynecology, 3, 383-385. doi: 10.4236/ojog.2013.34071.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Sibilia, J. (2003) Syndrome des antiphospholipides: Pourquoi faut-il y penser et comment faire le diagnostic. Revue du Rhumatisme, 70, 228-234. doi:10.1016/S1169-8330(03)00057-7
[2] Carbonne, B. and Lejeune, V. (2003) Modalités thérapeutiques d’une maladie abortive d’origine dysimmunitaire. Gynécologie Obstétrique & Fertilité, 31, 789-793. doi:10.1016/S1297-9589(03)00210-8
[3] Arvieux, J. and Hachulla, E. (2002) Le syndrome des antiphospholipides. Annales de Cardiologie et d Angéiologie, 51, 146-151. doi:10.1016/S0003-3928(02)00087-2
[4] Firkin, B.G., Howard, M.A. and Radford, N. (1980) Possible relationship between lupus inhibitor and recurrent abortion in young women. Lancet, 2, 366. doi:10.1016/S0140-6736(80)90361-X
[5] Lejeune, V. (2006) Fausses couches spontanées précoces répétées: Quelleprise encharge proposer en 2006? Gynécologie Obstétrique & Fertilité, 34, 927-993. doi:10.1016/j.gyobfe.2006.08.008
[6] Nielsen, H.S. and Christiansen, O.B. (2005) Prognostic impact of anticardiolipin antibodies in women with recurrent miscarriage negative for the lupus anticoagulant. Human Reproduction, 20, 1720-1728. doi:10.1093/humrep/deh790
[7] Wilson, W.A., Gharavi, A.E. and Koike, T. (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome. Arthritis & Rheumatism, 42, 1309-1311. doi:10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F
[8] De Maistre, E. (2003) Anticorps dits antiphospholipides et troubles de la reproduction: Les données biologiques. Gynécologie Obstétrique & Fertilité, 31, 794-796. doi:10.1016/S1297-9589(03)00207-8
[9] Meyer, O. (2003) Lupus et autres connectivites et vie hormonale. Gynécologie Obstétrique & Fertilité, 31, 746-756. doi:10.1016/S1297-9589(03)00203-0
[10] Branch, D.W., Peaceman, A.M., Druzin, M., et al. (2000) Multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. American Journal of Obstetrics & Gynecology, 122-182. doi:10.1016/S0 002-9378(00)70500-X
[11] Xiong, J. and Zhu, F.F. (2013) Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome. Experimental and Therapeutic Medicine, 5, 287-291.
[12] Shrimati, S. and Kanjaksha, G. (2009) Anti-phospholipid antibodies and other immunological causes of recurrent foetal loss: A review of literature of various therapeutic protocols. American Journal of Reproductive Immunology, 62, 9-24.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.