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Two Unusual Cases of Sudden Death in Children

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DOI: 10.4236/ojpathology.2013.32013    3,695 Downloads   5,246 Views   Citations

ABSTRACT

We report two unusual cases of sudden unexpected death in children. Histopathologic examination showed intimal fibroplasias, a variant of fibromuscular dysplasia of the right coronary artery associated in both cases with fatty infiltration of the right ventricular myocardium. The significance of this particular combination of two lesions known to induce a sudden death in young people is discussed.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

M. Osterheld and M. Perez, "Two Unusual Cases of Sudden Death in Children," Open Journal of Pathology, Vol. 3 No. 2, 2013, pp. 69-72. doi: 10.4236/ojpathology.2013.32013.

References

[1] M. J. Davies, “The Investigation of Sudden Cardiac Death,” Histopathology, Vol. 34, No. 2, 1999, pp. 93-98. doi:10.1046/j.1365-2559.1999.00648.x
[2] K. R. Thomas, S. P. Thomas, K. O. Hewan-Lowe and J. P. Pestaner, “Fibromuscular Dysplasia in Association with Intrauterine Cocaine Exposure,” Cardiovascular Pathology, Vol. 16, No. 5, 2007, pp. 313-316. doi:10.1016/j.carpath.2006.12.004
[3] M. Imamura, S. Yokoyama and K. Kikuchi, “Coronary Fibromuscular Dysplasia Presenting as Sudden Infant Death,” Archives of Pathology & Laboratory Medicine, Vol. 121, No. 2, 1997, pp. 159-161.
[4] F. Zack, H. Terpe, U. Hammer and R. Wegener, “Fibromuscular Dysplasia of Coronary Arteries as a Rare Cause of Death,” International Journal of Legal Medicine, Vol. 108, No. 4, 1996, pp. 215-218. doi:10.1007/BF01369795
[5] A. Fletcher, S. Y. Ho, K. P. McCarthy and M. N. Sheppard, “Spectrum of Pathological Changes in Both Ventricles of Patients Dying Suddenly with Arrhythmogenic Right Ventricular Dysplasia. Relation of Changes to Age,” Histopathology, Vol. 48, No. 4, 2006, pp. 445-452. doi:10.1111/j.1365-2559.2006.02356.x
[6] F. Fontaliran, S. Arkwright, F. Vilde and G. Fontaine, “Arrhythmogenic Right Ventricular Dysplasia and Cardiomyopathy. Clinical and Anatomic-Pathologic Aspects, Nosologic Approach,” Archives d’Anatomie et de Cytologie Pathologiques, Vol. 46, No. 3, 1998, pp. 171-177.
[7] F. Calabrese, C. Basso, E. Carturan, M. Valente and G. Thiene, “Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Is There a Role for Viruses?” Cardiovascular Pathology, Vol. 15, No. 1, 2006, pp. 11-17. doi:10.1016/j.carpath.2005.10.004
[8] E. Moric-Janiszewska and G. Markiewicz-Loskot, “Review on the Genetics of Arrhythmogenic Right Ventricular Dysplasia,” Europace, Vol. 9, No. 5, 2007, pp. 259-266. doi:10.1093/europace/eum034
[9] A. Rampazzo, A. Nava, G. A. Danieli, G. Buja, L. Daliento, G. Fasoli, R. Scognamiglio, D. Corrado and G. Thiene, “The Gene for Arrhythmogenic Right Ventricular Cardiomyopathy Maps to Chromosome 14q23-q24,” Human Molecular Genetics, Vol. 3, No. 6, 1994, pp. 959-962. doi:10.1093/hmg/3.6.959
[10] A. Rampazzo, A. Nava, P. Erne, M. Eberhard, E. Vian, P. Slomp, N. Tiso, G. Thiene and G. A. Danieli, “A New Locus for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVD2) Maps to Chromosome 1q42-q43,” Human Molecular Genetics, Vol. 4, No. 11, 1995, pp. 2151-2154. doi:10.1093/hmg/4.11.2151
[11] J. B. Senac, “Traité de la Structure du Coeur, de son Action et de ses Malades,” 2nd Edition, Mequignon, Paris, 1783, pp. 384-388.
[12] R. T. H. Laennec, “Treatise on Mediate Auscultation,” Vol. 2, Brosson and Claude, Paris, 1819, pp. 295-315.
[13] R. Quain, “Fatty Diseases of the Heart,” Medico-Chirurgical Transactions, Vol. 33, 1850, pp. 121-152.
[14] A. H. Jacobi, A. Gohari, B. Zalta, M. W. Stein and L. B. Haramati, “Ventricular Myocardial Fat: CT Findings and Clinical Correlates,” Journal of Thoracic Imaging, Vol. 22, No. 2, 2007, pp. 130-135. doi:10.1097/01.rti.0000213576.39774.68
[15] H. Suzuki, H. Daida, H. Sakurai and H. Yamaguchi, “Familial Fibromuscular Dysplasia of Bilateral Brachial Arteries,” Heart, Vol. 82, No. 2, 1999, pp. 251-252.
[16] E. Maresi, G. Becchina, G. Ottoveggio, E. Orlando, R. Midulla and R. Passantino, “Arrhythmic Sudden Cardiac Death in a 3-Year-Old Child with Intimal Fibroplasia of Coronary Arteries, Aorta, and Its Branches,” Cardiovascular Pathology, Vol. 10, No. 1, 2001, pp. 43-48. doi:10.1016/S1054-8807(00)00047-8
[17] F. E. Dominguez, L. G. Tate and M. J. Robinson, “Familial Fibromuscular Dysplasia Presenting as Sudden Death,” American Journal of Cardiovascular Pathology, Vol. 2, No. 3, 1988, pp. 269-272.
[18] K. Kaneko, T. Someya and R. Ohtaki, “Congenital Fibromuscular Dysplasia Involving Multivessels in an Infant with Fatal Outcome,” European Journal of Pediatrics, Vol. 163, No. 4-5, 2004, pp. 241-244. doi:10.1007/s00431-003-1312-x
[19] A. P. Burke and R. Virman, “Intramural Coronary Artery Dysplasia of the Ventricular Septum and Sudden Death,” Human Pathology, Vol. 29, No. 10, 1998, pp. 1124-1127. doi:10.1016/S0046-8177(98)90424-5
[20] K. M. Ropponen and I. Alafuzoff, “A Case of Sudden Death Caused by Fibromuscular Dysplasia,” Journal of Clinical Pathology, Vol. 52, 1999, pp. 541-542. doi:10.1136/jcp.52.7.541
[21] G. E. Pate, R. Lowe and C. E. Buller, “Fibromuscular Dysplasia of the Coronary and Renal Arteries?” Catheterization and Cardiovascular Interventions, Vol. 64, No. 2, 2005, pp. 138-145. doi:10.1002/ccd.20246

  
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