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How different is early-onset childhood disintegrative disorder from autistic disorder with speech loss?

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DOI: 10.4236/ojpsych.2013.32A007    3,771 Downloads   6,101 Views  

ABSTRACT


To examine the difference between early-onset (< age 3) childhood disintegrative disorder (CDD) and autistic disorder with speech loss (ADSL), 8 children with early-onset CDD (mean age = 7.6 years, SD = 3.8; 6 males) were compared with 92 age and gender-ratio comparable children with ADSL (mean age = 6.8 years, SD = 4.1; 70 males) on 24 variables not directly related to the key features of CDD (regression after normal development for at least the first 2 years after birth). Compared with the ADSL group, the early-onset CDD group had a tendency to have a higher rate of a psychosocial event before speech loss (SL) (early-onset CDD, 75.0% vs ADSL, 37.0%, p = 0.057; effect size (phi) = 0.211, p < 0.05); a significantly higher rate of fearfulness during SL (62.5% vs 4.3%, p = 0.000; phi = 0.551, p < 0.05); and a tendency to have a higher rate of epilepsy (25.0% vs 3.3%, p = 0.050; phi = 0.271, p < 0.05), a tendency to have a lower rate of the Childhood Autism Rating Scale-Tokyo Version (CARS-TV) total score ≥ 30 (75.0% vs 95.7%, p = 0.072; phi = 0.236, p < 0.05), and a significantly lower rate of CARS-TV item 2 (imitation) score ≥ 2 (50.0% vs 82.6%, p = 0.049; phi = 0.221, p < 0.05) on the first visit. The two groups did not exhibit any significant difference in the other 19 variables. The findings of no significant difference in the great majority and a significant difference in the small minority of the 24 variables between the two groups support integrating CDD into regressive autism spectrum disorder and studying CDD as its prototypical form.


Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Kurita, H. and Inoue, K. (2013) How different is early-onset childhood disintegrative disorder from autistic disorder with speech loss?. Open Journal of Psychiatry, 3, 39-45. doi: 10.4236/ojpsych.2013.32A007.

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