Investigation of the serum oxidative stress in broilers fed on diets supplemented with nickel chloride

Bangyuan Wu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Jianying Huang

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, China..
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China.
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China..

DOI: 10.4236/health.2013.53061                

Abstract

The purpose of this study was to investigate the serum oxidative stress induced by dietary nickel chloride (NiCl₂) in broilers. A total of 240 one-day-old avian broilers were divided into four groups and fed on a cornsoybean basal diet as control diet or the same basal diet supplemented with 300 mg/kg, 600 mg/kg and 900 mg/kg NiCl₂. During the experimental period of 42 days, oxidative stress parameters were determined for both control and experimental groups. The results showed that malondialdehyde (MDA) content was significantly higher (p < 0.05 or p < 0.01) in the 300 mg/kg, 600 mg/kg and 900 mg/kg groups than that in the control group. In contrast, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione per- oxidase (GSH-Px), and the ability to inhibit hydroxy radical, and glutathione hormone (GSH) content were significantly decreased (p < 0.05 or p < 0.01) in the 300 mg/kg, 600 mg/kg and 900 mg/kg groups in comparison with those of the control group. It was concluded that dietary NiCl₂ in excess of 300 mg/kg could cause oxidative stress, which could finally impaired the antioxidant function in broilers.

Keywords

Broiler; Nickel Chloride; Oxidative Stress; Serum

Conflicts of Interest

The authors declare no conflicts of interest.

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