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Investigation of the serum oxidative stress in broilers fed on diets supplemented with nickel chloride

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DOI: 10.4236/health.2013.53061    3,494 Downloads   4,760 Views   Citations


The purpose of this study was to investigate the serum oxidative stress induced by dietary nickel chloride (NiCl2) in broilers. A total of 240 one-day-old avian broilers were divided into four groups and fed on a cornsoybean basal diet as control diet or the same basal diet supplemented with 300 mg/kg, 600 mg/kg and 900 mg/kg NiCl2. During the experimental period of 42 days, oxidative stress parameters were determined for both control and experimental groups. The results showed that malondialdehyde (MDA) content was significantly higher (p < 0.05 or p < 0.01) in the 300 mg/kg, 600 mg/kg and 900 mg/kg groups than that in the control group. In contrast, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione per- oxidase (GSH-Px), and the ability to inhibit hydroxy radical, and glutathione hormone (GSH) content were significantly decreased (p < 0.05 or p < 0.01) in the 300 mg/kg, 600 mg/kg and 900 mg/kg groups in comparison with those of the control group. It was concluded that dietary NiCl2 in excess of 300 mg/kg could cause oxidative stress, which could finally impaired the antioxidant function in broilers.

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The authors declare no conflicts of interest.

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Wu, B. , Cui, H. , Peng, X. , Fang, J. , Zuo, Z. , Deng, J. and Huang, J. (2013) Investigation of the serum oxidative stress in broilers fed on diets supplemented with nickel chloride. Health, 5, 454-459. doi: 10.4236/health.2013.53061.


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