Synthesis and in Vitro Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates

Hanan Sekkak, El Mostapha Rakib, Medaghri-Alaoui Abdelouahid, Abderrafia Hafid, Abdelghani El Malki

Laboratoire de Chimie Organique et Analytique, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni-Mellal,Morocco.

DOI: 10.4236/ijoc.2013.31003                

Abstract

N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.

Keywords

Nitrile Imines; Cycloaddition; Pyrazoles; Cytotoxic Activity

Conflicts of Interest

The authors declare no conflicts of interest.

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