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Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37

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DOI: 10.4236/ojmm.2013.31012    2,635 Downloads   4,733 Views   Citations

ABSTRACT

Both bacterial and host factors contribute to complicated bloodstream infection (BSI) caused by Staphylococcus aureus including methicillin-resistant S. aureus (MRSA). One bacterial factor that may affect the persistence of S. aureus in complicated BSI is reduced susceptibility to the innate immune defence peptide LL-37. LL-37 susceptibility among S. aureus isolates causing uncomplicated and complicated BSI was investigated. Following incubation with 2.5 μg/ml LL-37 for 1 h, the mean percentage survival was 67.6% and 74.9% for isolates causing uncomplicated and complicated BSI, respectively. Reduced LL-37 susceptibility may contribute to the persistence of S. aureus in complicated BSI.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

S. McNicholaswhj, H. Humphreys and D. Hughes, "Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37," Open Journal of Medical Microbiology, Vol. 3 No. 1, 2013, pp. 80-83. doi: 10.4236/ojmm.2013.31012.

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