Bone-marrow derived cells participate in extramedullary hematopoiesis in a model of acetaminophen-induced acute liver failure in rats

Maria Cristina Belardinelli, Mónica López, Talita Giacomet de Carvalho, Fabiana Mayer, Guilherme Baldo, Luise Meurer, Roberto Giugliani, Ursula Matte

Gene Therapy Center, Research Center of Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
Pathology Service of Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.

DOI: 10.4236/scd.2013.31007                

Abstract

Adult derived mononuclear bone marrow cells are a good alternative as cell therapy. These cells are capable of significantly improve survival rate of Wistar rats with acetaminophen (APAP) induced acute liver failure in ten days. However, long term of cell therapy is not deeply studied in the literature. Here, we report an extramedullary hematopoiesis process derived from transplanted mononuclear bone marrow cells in the liver of rats 10 days after APAP injection. This result indicates that liver maintains an adequate microenvironment for the occurrence of extramedullary hematopoiesis process. The consequence of this finding deserves more studies.

Keywords

Extramedullary Hematopoiesis; Bone Marrow Cells; Acute Liver Failure; Acetaminophen

Conflicts of Interest

The authors declare no conflicts of interest.

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