Antimicrobial activity of the autochthonous compound Enoxil
Lucian Lupaşcu, Valeriu Rudic, Viorica Cotos, Tudor Lupaşcu
.
DOI: 10.4236/jbise.2010.38101   PDF    HTML     4,433 Downloads   8,833 Views   Citations

Abstract

The paper presents data about the antimicrobial activity of the autochthonous compound of taninic source Enoxil. The minimal inhibitory and bactericidal/fungicidal concentrations were established for some skin and wound infectious agents. It was established, based on Pseudomonas bacteria model, that the Enoxil compound suppress the activity of some important enzymes—a phenomenon that leads to the increase of bacterial sensibility to many tested antibiotics.

Share and Cite:

Lupaşcu, L. , Rudic, V. , Cotos, V. and Lupaşcu, T. (2010) Antimicrobial activity of the autochthonous compound Enoxil. Journal of Biomedical Science and Engineering, 3, 758-762. doi: 10.4236/jbise.2010.38101.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Dogra, S. and Kumar, B. (2003) Epidemiology of skin diseases in school children: A study from Northern India. Pediatric Dermatology, 20(6), 470-473.
[2] Collier, M. (2002) Wound-bed management: Key principles for practice. Professional Nurse, 18(4), 221-225.
[3] Cooper, R. (2002) Wound microbiology: Past, present, and future. British Journal of Nursing, 11(22), 4-6.
[4] Miller, M. (2001) Wound infection unravelled. Journal of Community Nursing, 15(3), 31-33.
[5] Nosocomial Infection National Surveillance Service (2002) Surveillance of surgical site infection in English hospitals: A national surveillance and quality improvement programme. Health Protection Agency, London.
[6] Singh, N.P., Goyal, R., Manchanda, V., et al. (2003) Changing trends in bacteriology of burns in the burns unit. Burns, 29(2), 129-132.
[7] Prisacari, V. and Paraschiv, A. (2008) Contrubutions in the epidemiological surveillance systems optimization within nosocomial septico-purulent infections of surgical profile. Epidemiology and Microbiology. Mat. Congress VI of Hygienists, Epidemiologists and Microbiologists from the Republic of Moldova, Chi?in?u, 2, 22-25.
[8] Rodgers, G., Mortensen, J., Fisher, M., et al. (2000) Predictors of infectious complications after burn injuries in children. Pediatric Infectious Disease Journal, 19(10), 990-995.
[9] Gang, R.K., Bang, R.L., Sanyal, S.C., et al. (1999) Pseudomonas aeruginosa septicaemia in burns. Burns, 25(7), 611-616.
[10] Kehheth, T. (2008) Pseudomonas aeruginosa. http://www. textbookofbacteriology.net/pseudomonas.html
[11] Rozhavin, M.A. (1983) Some biological properties of the P.aeruginosa melanin. Journal of Microbiology, in Russian, 1, 45-47.
[12] Valencia, I., Kirsner, R. and Kerdel, F. (2004) Microbiologic evaluation of skin wounds: Alarming trend toward antibiotic resistance in an inpatient dermatology service during a 10-year period. Journal of the American Academy of Dermatology, 50(6), 845-849.
[13] Visnevchi, L. and Bradu, V. (2008) Antibiotical microorganisms resistance modification, tested in the microbiological laboratory of PRMC Ungheni. Epidemiology and Microbiology. Mat. Congress VI of Hygienists, Epidemiologists and Microbiologists from the Republic of Moldova, Chi?in?u, 2, 264-265.
[14] Schwaber, M.J., Cosgrove, S.E., Gold, H.S., et al. (2004) Fluoroquinolones protective against cephalosporin resistance in gram-negative nosocomial pathogens. http://www. medscape.com/viewarticle/466484
[15] Asres, K., Mazumder, A. and Bucar, F. (2006) Antibacterial and antifungal activities of extracts of combretum molle. Ethiopian Medical Journal, 44(3), 269-277.
[16] Santos, S.C. and Mello, J.C.P. (2004) Taninos. Farmacognosia da Planta ao Medicamento, in Portuguese, 5th Edition, Porto Alegre, Florianópolis, 615-656.
[17] Timbola, A.K., Szpoganicz, B., Branco, A., et al. (2002) A new flavonol from leaves of Eugenia jambolana. Fitoterapia, 73(2), 174-176.
[18] Chung, K., Lu, Z. and Chou, M. (1998) Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria. Food and Chemical Toxicology, 36(12), 1053-1060.
[19] Kulci?ki, V., Vlad, P., Duca, G., et al. (2007) Investigation of grape seed proantocyanidins. Chemistry Journal of Moldova, 2(1), 36-50.
[20] Lupascu, T. and Lupascu, L. (2006) The obtaining procedure of the watersoluble enotannins. Patent Nr. 3125. MD. BOPI: 8.
[21] Andrews, J.M. (2001) Determination of minimum inhibitory concentrations. Journal of Antimicrobial Chemotherapy, 48(1), 5-16.
[22] National Committee for Clinical Laboratory Standards (NCCLS) (2002) Performance standards for antimicrobial susceptibility testing. 12th Informational Supplement M100–S12 NCCLS, Wayne.
[23] Halafian, A.A. (2008) Modern statistical methods of medical research. In Russian, LKI Publishers, Moscow.
[24] Matcovschi, C., Procopisin, V. and Parii, B. (2006) Phar- macotherapeutical guide. Central Printing, Chi?in?u.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.