Structure and properties of bone-like-nanohydroxyapatite/gelatin/polyvinyl alcohol composites
Feng Wang, Enyan Guo, Enmin Song, Ping Zhao, Jinhua Liu
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DOI: 10.4236/abb.2010.13026   PDF    HTML     6,677 Downloads   13,098 Views   Citations

Abstract

Bone-like nanohydroxyapatite powders (b-nanoHA) were synthesized in simulated body fluid (SBF). The b-nanoHA, gelatin (Gel) and Polyvinyl Alcohol (PVA) were used to prepare bone-like composites (b-nanoHA/ Gel/PVA) at room temperature. Characterizations of b-nanoHA powders and b-nanoHA/Gel/PVA composites were investigated by using X-ray diffraction (XRD), transmission electron microscopy (TEM), High-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). Bending strength and compressive strength of the composite were tested. It was found that microstructure of the b-nanoHA powders was whisker shape and its crystalline degree was low similar to natural bone, bending strength and compressive strength of the b-nanoHA/Gel/PVA composite depended on the mixing ratio of HA, Gel and PVA, and also PVA could induce the network formation in the b-nanoHA/Gel/ PVA composite.

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Wang, F. , Guo, E. , Song, E. , Zhao, P. and Liu, J. (2010) Structure and properties of bone-like-nanohydroxyapatite/gelatin/polyvinyl alcohol composites. Advances in Bioscience and Biotechnology, 1, 185-189. doi: 10.4236/abb.2010.13026.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Hench, L.L. (1991) Bioceramics: From concept to clinic. Journal of America Ceramic Society, 74(7), 1487-1510.
[2] Larry, L.H. (1998) Biomaterials: A forecast for the future. Biomaterials, 19(16), 1419-1423.
[3] Koutsopoulos, S. (2002) Synthesis and characterization of hydroxyapatite crystals: A review study on the analy- tical methods. Journal of Biomedical Materials Research, 62(4), 600-612.
[4] Weiner, S. and PRICE, P. (1986) Disaggregation of bone into crystals. Calcified Tissue International, 39(5), 365- 375.
[5] Salyer, K.E. and Hall, C.D. (1989) Porous hydroxya- patite as an only bone graft substitute for maxillofocid surgery. Plast Reconstructive Surgery, 84, 236-244.
[6] Bako?, D., Soldán, M. and Hernández-Fuentes, I. (1999) Hydroxyapatite-collagen-hyaluronic acid composite. Bio- materials, 20(2), 191-195.
[7] Chang, M.C., Ko, C.C and Douglas W.H. (2003) Preparation of hydroxyapatite-gelatin nanocomposite. Biomaterials, 24(17), 2853-2862.
[8] Chang, M.C. and Douglas, W.H. (2007) Cross-linkage of hydroxyapatite/gelatin nanocomposite using imide-based zero-length cross-linker. Journal of Materials Science: Materials in Medicine, 18(10), 2045-2051.
[9] Chang, M.C. (2008) Organic-inorganic interaction between hydroxyapatite and gelatin with the aging of gelatin in aqueous phosphoric acid solution. Journal of Materials Science: Materials in Medicine, 19(11), 3411- 3418.
[10] Fratzl, P., Groschner, M., Vogl, G., Plenk, H., Jr, Esch- berger, J., Fratzl-zelman, N., Koller, K. and Klaushofer, K. (1992) Mineral crystals in calcified tissues—a compa- rative study by SAXS. Journal of Bone Mineral Re- search, 7(3), 329-334.
[11] Su, X., Sun, K., Cui, F.Z. and Landis, W.J. (2003) Organization of apatite crystals in human woven bone. Bone, 32(2), 150-162.
[12] Lin, X.Y., Li, X.D., Fan, H.S., Xiao, Y.M., Lu, J. and Zhang X.D. (2005) Comparative investigation of copre -cipitation and in-situ synthesis of nanohydroxyapatite/ collagen composite. Key Engineering Materials, 284-286, 839-842.
[13] Charulatha, V. and Rajaram, A. (2003) Influence of diff- erent crosslinking treatments on the physical properties of collagen membranes. Biomaterials, 24(5), 759-767.
[14] Gilberto, G., Elcio, M., Rosemary, A.C.M., Rafael, C.C.L., Daniela, C.J.C. and Wanda, Maria de C. (1999) Biocompatibility studies of anionic collagen membranes with different degree of glutaraldehyde cross-linking. Biomaterials, 20(1), 27-34.
[15] Wang, M., Li, Y., Xu, F., Zhou, G. and Cheng, L. (2007) Synthesis and characterization of n-HA/PVA/Gel com- posite. Key Engineering Materials, 330-332, 471-474.
[16] Chang, M.C. (2005) Modification of hydroxyapatite/ gelatin composite by polyvinylalcohol. Journal of Mate- rials Science Letters, 40(2), 505-509.
[17] Suprabha, N. and Arvind, S. (2004) Systematic evolution of a porous hydroxyapatite-poly(vinylalcohol)-gelatin composite. Colloids and Surfaces B: Biointerfaces, 35(1), 29-32.
[18] Viitala, R., Simola, J., Peltola, T., Rahiala, H., Linden, M., Langlet, M. and Rosenholm, J.B. (2000) In vitro bioactivity of aerosol-gel deposited TiO2 thin coatings. Journal of Biomedical Materials Research, 54(1), 109- 114.
[19] Cüneyt, T.A. (2000) Synthesis of biomimetic Ca-hydro- xyapatite powders at 37°C in synthetic body fluids. Biomaterials, 21(14), 1429-1438.
[20] Carlstr?m, D. and Glas, J.E. (1959) The size and shape of the apatite crystallites in bone as determined from line- broadening measurements on oriented specimens. Bio- chimica et Biophysica Acta, 35, 46-53.
[21] Chang, M.C, Ko, C.C. and Douglas, W.H. (2003) Conformational change of hydroxyapatite/gelatin nanocomposite by glutaraldehyde. Biomaterials, 24(18), 3087- 3094.

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