Share This Article:

Epithelioid Angiosarcoma of Bone: A Neoplasm with Potential Pitfalls in Diagnosis

Full-Text HTML Download Download as PDF (Size:908KB) PP. 80-84
DOI: 10.4236/ojo.2012.23016    4,095 Downloads   6,249 Views   Citations

ABSTRACT

Angiosarcoma of bone is an exceedingly rare primary bone malignancy that can present as an aggressive osteolytic lesion. This subset can radiologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis. Meanwhile histological diagnosis can be extremely challenging too, as the pathological features often resemble that of aneurysmal bone cysts. We present an unusual case of a 22-year-old woman who presented with a rapidly growing humeral tumor of 8 months’ duration. The case of intraosseous angiosarcoma presented as a diagnostic dilemma and the relevant radiological and pathologic findings were discussed. We describe the clinical, radiological and pathological features of this unique case, and review the literature concerning Angiosarcoma of bone. Our case highlights the diagnostic difficulties for such very rare tumours and clinico-pathological correlation is of paramount importance to differential diagnosis.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

J. Xu, R. Ma, D. Li, L. Li, Z. Cai, W. Dong, Y. Chen and Y. Ding, "Epithelioid Angiosarcoma of Bone: A Neoplasm with Potential Pitfalls in Diagnosis," Open Journal of Orthopedics, Vol. 2 No. 3, 2012, pp. 80-84. doi: 10.4236/ojo.2012.23016.

References

[1] Volpe R, Mazabraud A, “Hemangioendothelioma (angiosarcoma) of bone: a distinct pathologic entity with an unpredictable course?,” Cancer, Vol.49, No.4, 1982, pp. 727-736.
[2] Weiss SW, Goldblum JR, “Enzinger and Weiss’s Soft Tissue Tumors,”Mosby, St. Louis, 2001.
[3] Unni KK, “Dahlin's bone tumors: general aspects and data on 11087 cases,”Lippincott-Raven, Philadelphia, 1996.
[4] Hasegawa T, Fujii Y, Seki K, Yang P, Hirose T, Matsuzaki K, Sano T, “Epithelioid angiosarcoma of bone,” Hum Pathol , Vol.28,No.8, 1997, pp. 985-989. doi:10.1016/S0046-8177(97)90016-2
[5] Saglik Y, Yildiz Y, Atalar H, Basarir K, “Primary angiosarcoma of the fibula: A case report,” Acta Orthop Belg , Vol.73, No.6, 2007,pp. 799-803.
[6] Cerilli LA, Fechner RE, “Angiosarcoma arising in a bone infarct,” Ann Diagn Pathol , Vol.3, No.6, 2007,pp. 370-373.doi: 10.1016/S1092-9134(99)80016-1
[7] Mittal S, Goswami C, Kanoria N, Bhattacharya A, “Post-irradiation an-giosarcoma of bone,” J Cancer Res Ther , Vol.3, No.2, 2007,pp. 96-99. doi:10.4103/0973-1482.34687
[8] Fukuroku J, Kusuzaki K, Murata H, Nakamura S, Takeshita H, Hirata M, Hashiguchi S, Hirasawa Y, “Two cases of secondary angiosarcoma arising from fibrous dysplasia,” Anticancer Res, Vol.19, No.5C, 1999, pp. 4451-4457.
[9] Voggenreiter G, Assenmacher S, Schmit-Neuerburg KP, “Tikhoff-Linberg procedure for bone and soft tissue tumors of the shoulder girdle,”Arch Surg, Vol.134, No.3, 1999, pp. 252-257.doi:10.1001/archsurg.134.3.252
[10] Chen KT, “Hemangiosarcoma complicating Paget's disease of the bone,” J Surg Oncol, Vol.28, No.3, 1985, pp. 187-189. doi:10.1002/jso.2930280308
[11] Dorfman HD, Steiner GC, Jaffe HL, “Vascular tumors of bone,” Hum Pathol, Vol.2, No.3, 1971, pp. 349-376. doi:10.1016/S0046-8177(71)80004-7
[12] Unni KK, Ivins JC, Beabout JW, Dahlin DC, “Hemangioma, hemangiopericytoma, and hemangioendothelioma (angiosarcoma) of bone,” Cancer, Vol.27, No.6, 1971,pp. 1403-1414.
[13] Garcia-Moral CA, “Malignant hemangioendothelioma of bone. Review of world literature and report of two cases,” Clin Orthop Relat Res, Vol.82, 1972, pp. 70-79. doi:10.1097/00003086-197201000-00009
[14] Bohn LE, Dehner LP, Walker HJ, “Case report 204. Multicentric angi-osarcoma of bone involving the right lower extremity,” Skeletal Radiol, Vol.8, No.34, 1982, pp. 303-305. doi:10.1007/BF02219628
[15] Campanacci M, Boriani S, Giunti A, “Hemangioendothelioma of bone: a study of 29 cases,” Cancer , Vol.46, No.4, 1980, pp. 804-814.
[16] Fedok FG, Levin RJ, Maloney ME, Tipirneni K, “Angiosarcoma: current review,” Am J Otolaryngol , Vol.20, No.4, 1999, pp. 223-231. doi:10.1016/S0196-0709(99)90004-2
[17] Kalantar MM, “Aneurysmal bone cysts of the jaws: clinicopathological features, radiographic evaluation and treatment analysis of 17 cases,” J Craniomaxillofac Surg, Vol.26, No.1, 1998, pp. 56-62. doi:10.1016/S1010-5182(98)80036-X
[18] Motamedi MH, Yazdi E, “Aneurysmal bone cyst of the jaws: analysis of 11 cases,” J Oral Maxillofac Surg, Vol.52, No.5, 1994, pp. 471-475. doi:10.1016/0278-2391(94)90343-3
[19] Smith SE, Kransdorf MJ, “Primary musculoskeletal tumors of fibrous origin,” Semin Musculoskelet Radiol, Vol.4, No.1, 2000, pp. 73-88. doi:10.1055/s-2000-6856
[20] Santeusanio G, Bombonati A, Tarantino U, Craboledda P, Marino B, Birbe R, Ortenzi A, Villaschi S, “Multifocal epithelioid angiosarcoma of bone: a potential pitfall in the differential diagnosis with metastatic carcinoma,”Appl Immunohistochem Mol Morphol, Vol.11, No.4, 2003, pp. 359-363. doi:10.1097/00129039-200312000-00014
[21] Wenger DE, Wold LE, “Malignant vascular lesions of bone: radiologic and pathologic features,”Skeletal Radiol, Vol.29, No.1, 2000, pp. 619-631. doi:10.1007/s002560000261
[22] Verhaven E, De Boeck H, Opdecam P, “Osteosarcoma appearing as a pathologic fracture,”Acta Orthop Belg, Vol.57, No.4, 1991, pp. 437-441.
[23] Coldwell DM, Baron RL, Charnsangavej C, “Angiosarcoma. Diagnosis and clinical course,”Acta Radiol, Vol.30, No.6, 1989, pp. 627-631. doi:10.3109/02841858909174727
[24] Murphey MD, Fairbairn KJ, Parman LM, Baxter KG, Parsa MB, Smith WS, “From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation,”Radiographics , Vol.15, No.4, 1995, pp. 893-917.
[25] Dorfman HD, Czerniak B, “Bone cancers,”Cancer , Vol.75, No.1 Suppl, 1995, pp. 203-210.
[26] Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villa-fuerte J, Gebhardt MC, “Aneurysmal bone cyst: a review of 150 patients,” J Clin Oncol, Vol.23, No.27, 2005, pp. 6756-6762. doi:10.1200/JCO.2005.15.255
[27] Campanacci M, Bertoni F, Bacchini P, “Aneurysmal bone cyst. In Bone and soft tissue tumors,” Springer-Verlag, Vienna, 1990.
[28] Tse LF, Ek ET, Slavin JL, Schlicht SM, Choong PF, “Intraosseous angiosarcoma with secondary aneurysmal bone cysts presenting as an elusive diagnostic challenge,”Int Semin Surg Oncol, Vol.5, 2008, pp. 10. doi:10.1186/1477-7800-5-10
[29] De Young BR, Frierson HJ, Ly MN, Smith D, Swanson PE, “CD31 immunoreactivity in carcinomas and mesotheliomas,”Am J Clin Pathol, Vol.110, No.3, 1998, pp. 374-377.

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.