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Tetramethrin Identified in Fat Adjacent to Mammary Carcinoma in a Male Dog—Case Report

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DOI: 10.4236/ojpathology.2012.23019    3,368 Downloads   5,814 Views  

ABSTRACT

Canine mammary tumors (CMT) are very common in female dogs, representing approximately 50% of all tumors in this species, but are highly uncommon in male dogs and are primarily related to hyperestrogenism. There is considerable scientific interest in the possible role of environmental contaminants in the etiology of mammary tumors, specifically in relation to synthetic chemical substances released into the environment to which living beings are either directly or indirectly exposed. In this study, the presence of pyrethroid insecticide was observed in adipose tissue adjacent to canine mammary tumors. High Precision Liquid Chromatography—HPLC was adapted to detect and identify environmental contaminants in adipose tissue adjacent to malignant mammary tumor in one male dog, Akita, 12 years old. After surgery, the mass was carefully examined for malignant neoplastic lesions. Five grams of adipose tissue adjacent to the tumor was collected to detect environmental contaminants. The pyrethroid was identified as tetramethrin, at 0.20 μg/g. This is the first report in which the environmental contaminant level was detectable in adipose tissue of this male dog with a malignant mammary tumor, by HPLC. Results suggest the possible involvement of pyrethroid in the canine mammary tumor carcinogenesis since this animal did not present any other tumor that could cause hyperestrogenism.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

F. C. Figueiroa, P. Ricardo O. Bersano, F. Henrique E. Andrade and N. S. Rocha, "Tetramethrin Identified in Fat Adjacent to Mammary Carcinoma in a Male Dog—Case Report," Open Journal of Pathology, Vol. 2 No. 3, 2012, pp. 102-105. doi: 10.4236/ojpathology.2012.23019.

References

[1] C. R. Daleck, et al., “Aspectos Clínico e Cirúrgicos do Tumor de Mama Canino,” Ciência Rural, Santa Maria, Vol. 28, No. 1, 1998, pp. 95-100. doi:10.1590/S0103-84781998000100016
[2] F. Queiroga and C. Lopes, “Tumores Mamários Caninos—Novas Perspectivas,” Proceedings of the Veterinary Sciences Congress, Oeiras, 10-12 October 2002, pp. 183-190.
[3] J. Harvey, “Glandulas Mamárias,” In: M. J. Bojrab, Ed., Técnicas Atuais em Cirurgia de Pequenos Animais, 3rd Edition, Chapter 35, Roca, Sao Paulo, 2005, pp. 425-430.
[4] C. S. Hedlund, et al., “Cirurgia dos Sistemas Reprodutivo e Genital,” In: T. W. Fossum, Ed., Cirurgia de Pequenos Animais, 2nd Edition, Chapter 28, Roca, Sao Paulo, 2005, pp. 610-672.
[5] V. R. Nerurkar, A. R. Chitale, B. V. Jalnapurkar, S. N. Naik and V. S. Lalitha, “Comparative Pathology of Canine Mammary Tumors,” Journal of Comparative Pathology, Vol. 101, No. 4, 1989, pp. 389-397. doi:10.1016/0021-9975(89)90022-4
[6] D. J. Meuten, “Tumors in Domestic Animals,” 4th Edition, University of California, Berkeley, 2002, pp. 575-606. doi:10.1002/9780470376928
[7] G. Perkins and L. Middleton, “Breast Cancer in Men,” British Medical Journal, Vol. 327, No. 7420, 2003, pp. 239-240. doi:10.1136/bmj.327.7409.239
[8] S. H. Giordano, D. S. Cohen, A. U. Buzdar, et al., “Breast Carcinoma in Men: A Population-Based Study,” Cancer, Vol. 101, 2004, pp. 51-57. doi:10.1002/cncr.20312
[9] R. Schneider, C. R. Dorn and D. O. N. Taylor, “Factors Influencing Canine Mammary Cancer Development and Postsurgical Survival,” Journal of the National Cancer Institute, Vol. 43, 1969, pp. 1249-1261.
[10] Instituto Nacional do Cancer (INCA), “Estimativa para 2005 da Incidência e Mortalidade por Cancer no Brasil,” Ministério da Saúde, Rio de Janeiro, 2006.
[11] S. M. Goulart, M. E. L. R. Queiroz, A. A. Neves, J. H. Queiroz and I. C. Alves, “Anais da 27? Reuni?o Anual da SBQ e 26? Congresso Latino Americano de Química,” Salvador, 2004.
[12] J. W. Wright, “The WHO Program for the Evaluation and Testing of New Insecticides,” Bulletin of the World Health Organization, Vol. 44, 1997, pp. 11-12.
[13] International Agency for Research Cancer, IARC, “Over- all Evaluations of Carcinogenicity to Humans,” IARC, Lyon, 2005. http://monographs.iarc.fr/ENG/Monographs/vol53/mono53-10.pdf
[14] Environmental Protection Agency, “Pyrethrins: Report of the Cancer Assessment Review Committee,” 3rd Evaluation, EPA, 2004. http://www.cepis.ops-oms.org/bvsacd/cd49/pesticide.pdf
[15] J. Garey and M. Wolff, “Estrogenic and Antiprogestagenic Activities of Pyrethroid Insecticides,” Biochemical and Biophysical Research Communications, Vol. 251, No. 3, 1998, pp. 855-859. doi:10.1006/bbrc.1998.9569
[16] A. E. Silva, et al., “Carcinogênese Hormonal e Neoplasias Horm?nio-Dependentes,” Ciência Rural, Santa Maria, Vol. 34, No. 2, 2004, pp. 625-633. doi:10.1590/S0103-84782004000200048
[17] D. Z. Bissacot and I. Vassilieff, “HPLC Determination of Flumethrin, Deltamethrin, Cypermethrin, and Cyhalothrin Residues in Milk and Blood of Lactating Dairy Cows,” Journal of Analytical Toxicology, Vol. 21, No. 5, 1997, pp. 397-402.
[18] L. Ackerman, “Reproductive Disorders,” The Genetic Connection: A Guide to Health Problems in Purebred Dogs, Colorado, AAHA Press, 1999.
[19] G. Daugaard, V. Karas and P. Sommer, “Inguinal Meta- stases from Testicular Cancer,” BJU International, Vol. 97: 2006, pp. 724-726. doi:10.1111/j.1464-410X.2006.06017.x
[20] F. H. E. Andrade, F. C. Figueiroa, P. R. O. Bersano, D. Z. Bissacot and N. S .Rocha, “Malignant Mammary Tumor in Female Dogs: Environmental Contaminants,” Diagnostic Pathology, Vol. 5, No. 45, 2010.

  
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