Tetramethrin Identified in Fat Adjacent to Mammary Carcinoma in a Male Dog—Case Report


Canine mammary tumors (CMT) are very common in female dogs, representing approximately 50% of all tumors in this species, but are highly uncommon in male dogs and are primarily related to hyperestrogenism. There is considerable scientific interest in the possible role of environmental contaminants in the etiology of mammary tumors, specifically in relation to synthetic chemical substances released into the environment to which living beings are either directly or indirectly exposed. In this study, the presence of pyrethroid insecticide was observed in adipose tissue adjacent to canine mammary tumors. High Precision Liquid Chromatography—HPLC was adapted to detect and identify environmental contaminants in adipose tissue adjacent to malignant mammary tumor in one male dog, Akita, 12 years old. After surgery, the mass was carefully examined for malignant neoplastic lesions. Five grams of adipose tissue adjacent to the tumor was collected to detect environmental contaminants. The pyrethroid was identified as tetramethrin, at 0.20 μg/g. This is the first report in which the environmental contaminant level was detectable in adipose tissue of this male dog with a malignant mammary tumor, by HPLC. Results suggest the possible involvement of pyrethroid in the canine mammary tumor carcinogenesis since this animal did not present any other tumor that could cause hyperestrogenism.

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F. C. Figueiroa, P. Ricardo O. Bersano, F. Henrique E. Andrade and N. S. Rocha, "Tetramethrin Identified in Fat Adjacent to Mammary Carcinoma in a Male Dog—Case Report," Open Journal of Pathology, Vol. 2 No. 3, 2012, pp. 102-105. doi: 10.4236/ojpathology.2012.23019.

Conflicts of Interest

The authors declare no conflicts of interest.


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