Elevated glucagon-like peptide-1 on a high-fat diet feeding prevents the incidence of diabetes mellitus in Spontaneously Diabetic Torii Lepr^fa rats

Takahiro Hata, Takeshi Ohta, Yukihito Ishii, Tomohiko Sasase, Takayuki Yamaguchi, Yasuko Mera, Katsuhiro Miyajima, Gimpei Tanoue, Eimei Sato, Mutsuyoshi Matsushita

Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka, Japan.
Japan Tobacco Inc., Central Pharmaceutical Research Institute, Toxicology Research Laboratories, Hadano, Japan.
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.

DOI: 10.4236/jdm.2012.22027                

Abstract

Nutritional regulation plays a critical role to reduce the incidence or progression of diabetes mellitus. In this study, we investigated the effects of a high-fat diet on Spontaneously Diabetic Torii Lepr^fa (SDT fatty) rats, a novel model for obese type 2 diabetes. The SDT fatty rats were divided into two dietary groups, which were fed a high-fat diet or a standard diet for 18 weeks, from 6 to 24 weeks of age. The calorie intake in the high-fat diet (HF) group was reduced after 10 weeks of age and the group inhibited an incidence of diabetes. Interestingly, the HF induced an increase of serum glucagon-like peptide-1 (GLP-1) levels in SDT fatty rats with refeeding. Fat tissue weights in the HF group increased, but the visceral fat/subcutaneous fat (V/S) ratio decreased. Moreover, histopathological observations revealed an improvement of the pancreatic abnormalities and fatty liver in the HF group. In conclusion, a preventive effect on diabetes in rats fed a high-fat diet has a relation with an increase in incretin hormone, and it might be advantageous for prevention of incidence or progression of diabetes to develop functional foods inducing an increase in incretin hormone.

Keywords

Glucagon-Like Peptide-1; High Fat Diets; SDT Fatty Rats

Conflicts of Interest

The authors declare no conflicts of interest.

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