Prognostic factors correlation between the cell cycle phases and apoptosis in basal cell carcinoma

Cyro Festa-Neto, Durvanei Augusto Maria

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DOI: 10.4236/ojim.2011.13019                

Abstract

Basal cell carcinoma (BCC) is the most common skin malignancy, are found in various forms depending on their clinical and biological behavior. The objective of study was analyzed the phases of the cell cycle and correlations between BCC of low and high risk of recurrence and correlation prognostic factors. The quantity of content DNA in tissues of normal skin, showed small amount of cells in apoptosis and mostly in phase quiescent and rare aneuploidy cells. In BCC, apoptosis was higher in the BCC at high risk than low risk, probably due to their high rates of cell proliferation, and present of aneuploidy cells, when compared to the average percentage of aneuploidy. The DNA content from cells of normal skin shows that the majority is in the quiescent phase; compatible with tissues that are is refreshing. There is presence of apoptosis in the epidermis by probable normal process of differentiation. The aneuploidy in BCC showed a direct correlation with the degree of tumor aggressiveness.

Keywords

Basal Cell Carcinoma; Cell Cycle Phases; Apoptosis; Nonmelanoma Skin Cancer; Aneuploidy

Conflicts of Interest

The authors declare no conflicts of interest.

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