Share This Article:

Initial Study of Electrospinning PCL/PLLA Blends

Abstract Full-Text HTML Download Download as PDF (Size:349KB) PP. 94-98
DOI: 10.4236/ampc.2011.13016    4,822 Downloads   10,184 Views   Citations


The process of electrospinning is considered one of the most promising methods for the fabrication of poly- mer nanofibers. This essentially consists of applying a high electric field, which causes stretching of the polymer which exits through a capillary. Among the numerous applications of this process, electrospinning allows the fabrication of semiconductor and conductive nanofibers from mixtures or solutions, which have great potential for applications in sensors and the fabrication of scaffolds for cell growth. The aim of this work was to analyze the properties of the blend, produces by the electrospinning of the PCL and PLLA solu- tion, with the focus to generate a promissory scaffold. PCL is a semi-crystalline aliphatic polymer that has a slower degradation rate 12 - 24 months. It has a low glass transition temperature at –60?C, a melting tem-perature at about 60?C, and a high thermal stability. Properties of PLA depend on the component isomers, processing temperature, annealing time and molecular weight. Thus were used PCL, from Aldrich, with Mw of 80,000 g/mol, and PLLA, sintered in laboratory, with Mw of 240,000 g/mol, were dissolved in chloroform (CHCl3, Merck) and acetone (Synth) by stirring for 6 hours. The solution was electrospinning for 1 hour us- ing the equipment made in the laboratory, the voltage used was 13 kv, the rate of 0.5 ml/h and an approxi- mate distance from the tip of the needle to the collector of 12 cm. The morphology of the samples was ob- served by images made with scanning electron microscopy (SEM) and also was analyzed by FT-IR and DSC.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

G. Cardoso, G. Perea, M. D’Avila, C. Dias, C. Zavaglia and A. Arruda, "Initial Study of Electrospinning PCL/PLLA Blends," Advances in Materials Physics and Chemistry, Vol. 1 No. 3, 2011, pp. 94-98. doi: 10.4236/ampc.2011.13016.


[1] R. Langer and J. P. Vacanti, “Tissue Engineering,” Sci- ence, Vol. 260, No. 5110, 1993, pp. 920-926.
[2] J. Y. Martin, Z. Schwartz, T. W. Hummert, D. L. Schraub, J. Simpson, J. Lankford, D. L. Cocharn and B. D. Boyan, “Effect of Titanium Surface Roughness on Proliferation, Differentiation, and Pro-tein Synthesis of Human Os- teoblast-Like Cells (MG63),” Journal of Biomedical Materials Research, Vol. 29, No. 3, 1995, pp. 389-401. doi:10.1002/jbm.820290314
[3] K. Kieswetter, Z. Schwartz, T. W. Hummert, D. L. Co- charn, J. Simpson and D. D. Dean, “Surface Roughness Modulates the Local Production of Growth Factors and Cytokines by Osteoblast-Like MG-63 Cells,” Journal of Biomedical Materials Research, Vol. 32, No. 1, 1996, pp. 55-63. doi:10.1002/(SICI)1097-4636(199609)32:155::AIDJBM7
[4] A. G. Mikos, G. Sarakinos, J. P. Vacanti, R. S. Langer and L. G. Cima, “Polymer Membranes and Methods of Preparation of Three Dimensional Membrane Structures,” US Patent No 5514378, 1996.
[5] L. D. Harris, B. Kim and D. J. Mooney, “Open Pore Bio- degradable Matrices Formed with Gas Foam-ing,” Journal of Biomedical Materials Research, Vol. 42, No. 3, 1998, pp. 396-402. doi:10.1002/(SICI)1097-4636(19981205)42:3<396::AID- JBM7>3.0.CO;2-E.
[6] D. W. Hutmacher, M. Sittinger and M. V. Risbud, “Scaf- fold-Based Tissue Engineering: Rationale for Computer- aided Design and Solid Free-Form Fabrication Systems,” Trends Biotechnology, Vol. 22, No. 7, 2004, pp. 354-362. doi:10.1016/j.physletb.2003.10.071
[7] C. M. Patist, M. B. Mulder, S. E. Gautier, V. Maquet, R. Jèr?me and M. Oudega, “Freeze-Dried Poly (D-L-Lactic Acid) Macroporous Guidance Scaffolds Impregnated with Brain-Derived Neurotrophic Factor in the Transected Adult Rat Thoracic Spinal Cord,” Biomaterials, Vol. 25, No. 9, 2004, pp. 1569-1582. doi:10.1016/j.physletb.2003.10.071
[8] A. P. T. Pezzin and E. A. R. Duek, “Hydrolytic Degrada- tion of Pol?y (Para-Dioxanone) Films Prepared by Casting or Phase Separa-tion,” Polymer Degradation and Stability, Vol. 78, No. 3, 2002, pp. 405-411. doi:10.1016/S0141-3910(02)00174-X
[9] Q. P. Pham, U. Sharma and A. G. Mikos, “Electrospinning of Polymeric Nano-fibers for Tissue Engineering Applications: A Review,” Tissue Engineering, Vol. 12, No. 5, 2006, pp. 1197-1211. doi:10.1089/ten.2006.12.1197
[10] F. Yang, S. K. Both, X. Yang, X. F. Walboomers and J. A. Jansen, “Development of an Electrospun Nano-Apatite/pcl Composite Membrane for gtr/gbr Application,” Acta Biomaterialia, Vol. 5, No. 9, 2009, pp. 3295-3304. doi:10.1016/j.actbio.2009.05.023
[11] G. B. C. Cardoso, S. L. F. Ramos, A. C. D. Rodas, C. A. C. Zavaglia and A. C. F. Ar-ruda, “Scaffolds of Poly (E-Caprolactone) with Whiskers of Hydroxyapatite,” Journal of Materials Science, Vol. 45, No. 18, 2010, pp. 4990-4993. doi:10.1007/s10853-010-4363-1
[12] L. Zhang, C. Xiong and X. Deng, “Biodegradable Polyesters Blends for Biomedical Application,” Journal of Applied Poly-mer Science, Vol. 56, No. 1, 1995, pp. 103- 112. doi:10.1002/app.1995.070560114
[13] A. C. Motta and E. A. R. Duek, “Synthesis, Characterization, and ‘in Vitro’ Degradation of Poly (L-Lactic Acid-co-Glycolic Acid,” Polímeros: Ciência e Tecnologia, Vol. 16, 2006, pp. 26-32. doi:10.1590/S0104-14282006000100007
[14] A. G. Mikos, G. Sarakinos, M. D. Lyman, D. E. Ingber, J. P. Vacanti and R. Langer, “Prevascularization of Porous Biodegradable Poly-mers,” Biotechnology and Bioengineering, Vol. 42, No. 6, 1993, pp. 716-723. doi:10.1002/bit.260420606
[15] X. Li, Y. Su, C. He, H. Wang, H. Fong and X. Mo, “Sorbitan Monooleate and Poly (L-Lactide-co-ε-Caprolactone) Electrospun Nanofibers for Endothelial Cell Interactions,” Journal Biomedical Materials Research Part A, Vol. 91A, No. 3, 2009, pp. 878-885. doi:10.1002/jbm.a.32286

comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.