Progress toward the Synthesis of Pochonin J ()
ABSTRACT
The construction of the C(1) - C(5) fragment of the resorcylic acid lactone pochonin J is described. The synthesis is marked by the installation of the cis-1,3-diol moiety in a highly stereoselective manner using Evans’ intra-molecular base-catalyzed oxyconjugate addition of a hemiacetal-derived nucleophile. The synthetic route presented affords an efficient pathway to the preparation of this critical architectural feature that should facilitate the development of this secondary metabolite as a potential drug candidate.
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Jackson, S. and Pongdee, R. (2019) Progress toward the Synthesis of Pochonin J.
International Journal of Organic Chemistry,
9, 96-105. doi:
10.4236/ijoc.2019.92009.
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