The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies ()
ABSTRACT
Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.
Share and Cite:
P. Panegyres and E. Atkins, "The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies,"
Neuroscience and Medicine, Vol. 2 No. 4, 2011, pp. 397-409. doi:
10.4236/nm.2011.24053.
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