Author(s)

Haichi Li^1*, Jinfang Ma^1*, Huanfen Xu², Yin Peng¹, Huazhuang Jiang¹, Zhaohua Shi³, Fahuan Ge¹

¹School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
²Guangzhou SonDon Network & Technology Co., Ltd., Guangzhou, China.
³Wuhan Aimin Pharmaceutical Co., Ltd., Ezhou, China.

To achieve a rapid and simple detection for the active ingredients of Aescin in the extraction process using near-infrared spectroscopy (NIR) and to realize the state monitoring and quality control of the extraction process. Partial least square regression (PLS) was applied to build the near-infrared calibration models, and the applicability of the model was investigated by predicting the unknown samples in the extraction process. The correlation coefficients of the established Aescin models (A, B, C, D) were 0.9836, 0.9831, 0.9833, 0.9824, and the prediction standard deviations (SEP) were 0.05636, 0.05043, 0.02412, 0.05636, respectively. This study suggests that the proposed model has superior stability and accuracy. NIR spectroscopy technique provides a novel efficient and environmentally friendly approach to the rapid determination of four Aescin key quality indicators (A, B, C, D) in the extraction, which was solved the problem that the lack of state monitoring during the extraction of Aescin, thereby improved the quality of Aescin.

NIR Spectroscopy, Aescin, Extraction Process, State Monitoring, Quality Control

Li, H.C., Ma, J.F., Xu, H.F., Peng, Y., Jiang, H.Z., Shi, Z.H. and Ge, F.H. (2018) A Rapid and Simple Quantitative Method for the Active Ingredients of Aescin in the Extraction Process Using Near Infrared Spectroscopy. American Journal of Analytical Chemistry, 9, 500-513. doi: 10.4236/ajac.2018.910037.