Author(s)

Raghda A. Elgendy¹, Wahib M. Attia², Ehab M. Attalla³, Mostafa A. lnaggar^1,4

¹Medical Physics Department, Ayady Al Mostakbal Oncology Center, Alexandria, Egypt.
²Physics Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
³Radiotherapy and Nuclear Medicine Department, National Cancer Institute, Cairo University, Giza, Egypt.
⁴Cancer Management and Research Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer. Material and methods: Fifteen patients in this study suffering from early stage of prostate cancer, each patient underwent three plans: 1) Three-dimensional conformal radiation therapy (3DCRT), 2) Rotation therapy (Arc therapy), and 3) intensity-modulated radiation therapy (IMRT) plan. Estimate secondary metastasis risk models: Excess Relative Risk (ERR) and Excess absolute risk (EAR) based on age of exposure by taking dosimetry data from Dose Volume Histograms (DVHs) to calculate risk models. Result: The second cancer risk models (ERR and EAR) for organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC and IMRT and there is no significant difference for ERR and EAR model for developing second cancer risk in 3D-CRT, ARC and IMRT.

Prostate Cancer, Second Cancer Risks, 3DCRT, Rotational Arc and IMRT

Elgendy, R. , Attia, W. , Attalla, E. and lnaggar, M. (2018) Influence of Dosimetric Considerations in Evaluating Second Cancer Risks in Prostate Cancer. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 7, 203-213. doi: 10.4236/ijmpcero.2018.72018.