Author(s)

H. Chen^1,2*, M. P. Huang¹, T. H. Huang¹, C. H. Jiang², J. W. Zeng², L. L. Zhou¹, Q. L. Liu¹, Q. Q. Li¹, X. Y. Yang¹

¹Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China.
²Departments of Urology, Qingyan City People’s Hospital, Jinan University, Guangdong, China.

Objective: To evaluate the efficacy and safety of botulinum toxin type A (BTX-A) in treating patients with low bladder compliance (BC) secondary to spinal cord injury (SCI). Methods: From 2011 to 2016, we retrospected patients who received BTX-A injections for LBC secondary to SCI. The primary outcomes were urodynamic parameters including maximum detrusor pressure (Pdetmax), bladder compliance (BC). Related adverse events were recorded. Results: 72 SCI patients were selected (62 males, 10 females, age range 18 - 52 years; mean age 28.5 years). 12 weeks after BTX-A injection, Pdetmax decreased from 51.02 cmH₂O to 28.31 cmH₂O. BC increased from 3.64 ml/cmH₂O to 10.08 ml/cmH₂O. 12 patients had mild transient haematuria for 1 - 2 days. Conclusion: Intradetrusor BTX-A injection was effective and safe for patients with low BC secondary to SCI.

Botulinum Toxin Type A, Low Bladder Compliance, Spinal Cord Injury

Chen, H. , Huang, M. , Huang, T. , Jiang, C. , Zeng, J. , Zhou, L. , Liu, Q. , Li, Q. and Yang, X. (2017) Therapeutic Outcome of Botulinum Toxin Type A for Patients with Low Bladder Compliance Secondary to Spinal Cord Injury. Open Journal of Urology, 7, 207-211. doi: 10.4236/oju.2017.711024.