old;">ePub,  PP. 137-164  
DOI: 10.4236/jbbs.2017.73013    1,292 Downloads   2,026 Views   Citations
S. Shaun Ho1,2, Yoshio Nakamura3


1Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
2Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
3Department of Anesthesiology, Pain Research Center, University of Utah School of Medicine, Salt Lake City, UT, USA.


In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.


Active Inference, Affects, Brain, Cortical Networks, Embodied Beliefs, Emotions, Emotion Regulation, Identity, Intervention, Mind-Body Wellbeing, Mind-Body Bridging, Neuroimaging, Psychopathology, Self

Cite this paper

Ho, S. and Nakamura, Y. (2017) Healing Dysfunctional Identity: Bridging Mind-Body Intervention to Brain Systems. Journal of Behavioral and Brain Science, 7, 137-164. doi: 10.4236/jbbs.2017.73013.

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[3] Investigating Clinical Benefits of a Novel Sleep-Focused Mind-Body Program on Gulf War Illness Symptoms: A Randomized Controlled Trial
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