Analysis of Serum Biochemical Indexes for the Diagnosis of Coronary Heart Disease in Suspected Patients ()
Affiliation(s)
1Department of Internal Neurology, Guangzhou Overseas Chinese Hospital, The First Affiliated Hospital of Jinan University, Guangzhou, China.
2Medical College of Jinan University, Guangzhou, China.
3Department of Cardiology, Guangzhou Overseas Chinese Hospital, The First Affiliated Hospital of Jinan University, Guangzhou, China.
ABSTRACT
Background: The serum biochemical indexes are classic detection in clinical
practice. Methods: In this study, for avoiding the risks of serious complications,
high-cost in diagnosis of suspected coronary heart disease (CHD), the common biochemical
indexes were detected from 68 eligible patients with suspected CHD. Treadmill exercises
test (TET)-electrocardiogram (ECG) was measured during TET, and invasive examination
of coronary angiography (CAG, golden standard for CHD diagnosis) was also performed.
Results: For CAG, 48 patients were positive and 20 were negative; while for TET
38 were positive, 14 were inconclusive, and 16 were negative, respectively. Among
these biochemical indexes, the HbA1c (%) level in CAG positive patients was much
higher than that in CAG negative patients (P = 0.019). Furthermore, according to receiver operating characteristic (ROC) curve,
HbA1c showed effective diagnosis for CHD and its best cutoff value was 5.85% and
29 of the patients were HbA1c positive and 30 were negative. Conclusions: It was
found that HbA1c combined with TET obviously enhanced the sensitivity of examinations.
All the patients who were negative in both HbA1c and TET tests turned out to be
90% CAG negative, which meant that the combination might stand invasive examination
of CAG for CHD diagnosis. Further studies in multi-center investigation will be
expected to validate the findings.
Share and Cite:
Mai, H. , Huang, Z. and Zhang, T. (2016) Analysis of Serum Biochemical Indexes for the Diagnosis of Coronary Heart Disease in Suspected Patients.
Open Access Library Journal,
3, 1-8. doi:
10.4236/oalib.1102389.