Author(s)

Gonul Vural^1*, Sadiye Gumusyayla¹, Hesna Bektas², Orhan Deniz¹, Merve Ergin³, Ozcan Erel⁴

¹Department of Neurology, School of Medicine, Yildirim Beyaz?t University, Ankara, Turkey.
²Department of Neurology, Atatürk Training and Research Hospital, Ankara, Turkey.
³Department of Clinical Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.
⁴Department of Clinical Biochemistry, School of Medicine, Yildirim Beyaz?t University, Ankara, Turkey.

Objective: The aim of this study was to evaluate thiol-disulphide homeostasis in patients with Multiple Sclerosis (MS) during attack and remission. Design and Methods: A total of 82 patients admitted to our clinic were divided into 2 groups according to whether they are having an attack or not. Peripheral blood samples were taken from all patients and their native thiol, disulphide and total thiol concentrations were measured by a newly developed automated method. In addition, their disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were calculated. Results: The average disulphide values, disulphide/native thiol and disulphide/total thiol ratios of the patients with MS who were having an attack were found to be significantly higher compared to those in remission (p = 0.001, p = 0.001, p = 0.001, respectively). Conclusion: Our results have shown that thiol-disulphide balance was shifted to the oxidative area during the relapse. These homeostasis parameters, which can be easily measured by this newly developed method at low costs, may be important in terms of showing the disease activity and presenting the underlying mechanisms of the disease.

Multiple Sclerosis, Relapse, Oxidative Stress, Thiol-Disulphide Homeostasis

Vural, G. , Gumusyayla, S. , Bektas, H. , Deniz, O. , Ergin, M. and Erel, O. (2016) Dynamic Thiol-Disulphide Homeostasis in Patients with Multiple Sclerosis. World Journal of Neuroscience, 6, 214-219. doi: 10.4236/wjns.2016.63026.