Author(s)

Ruswana Anwar¹, Firman F. Wirakusumah¹, Duddy S. Nataprawira¹, Ani M. Maskoen², Wiryawan Permadi¹, Tono Djuwantono¹

¹Department of Obstetrics and Gynecology, Faculty of Medicine, University of Padjadjaran Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
²Medical Research Unit, Faculty of Medicine, University of Padjadjaran, Bandung, Indonesia.

Aim: To identify the correlation between mRNA expression of aromatase, 17β-HSD2 level of TGF-β1 and stage of endometriosis. Methods: Case control study was done on 80 patients divided by 40 endometriosis patients and 40 patients as control. mRNA expression of aromatase, mRNA 17β-SD2, was checked using reverse-transcriptase polymerase chain reaction (RT-PCR) and TGF-β1 serum and peritoneal fluid was checked using ELISA. Result: Level of mRNA aromatase from ectopic and eutopic endometrium increased significantly compared to control group (p < 0.001). mRNA 17β-HSD2 expression is significantly lower compared to control (p < 0.001). Level of TGF-β1 on endometriosis group was significantly higher compared to control group (p < 0.05). Level of peritoneal fluid TGF-β1 on endometriosis group was higher than control group (p < 0.001). There are no correlations between mRNA aromatase, type 2 17β-HSD, TGF-β1 serum level to endometriosis stage. There are significant correlations between peritoneal fluid TGF-β1 levels to endometriosis stage.

Aromatase, 17βHSD2, TGFβ1, Stage Endometriosis

Anwar, R. , Wirakusumah, F. , Nataprawira, D. , Maskoen, A. , Permadi, W. and Djuwantono, T. (2016) Association between mRNA Expression of Aromatase, 17β-HSD2, Level of TGF-β1 and Stage of Endometriosis. Open Journal of Obstetrics and Gynecology, 6, 411-418. doi: 10.4236/ojog.2016.67054.