Development of Aseptic Renal Abscess in a Patient with Non-Small-Cell Lung Cancer with ALK Translocation during Crizotinib Treatment - Advances in Lung Cancer

ALC > Vol.4 No.4, December 2015

Volume 4, Issue 4 (December 2015)

ISSN Print: 2169-2718 ISSN Online: 2169-2726

Development of Aseptic Renal Abscess in a Patient with Non-Small-Cell Lung Cancer with ALK Translocation during Crizotinib Treatment ()

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DOI: 10.4236/alc.2015.44007 3,345 Downloads 5,251 Views Citations

Author(s)

Luciana Franco do Prado de Carvalho^1*, Andrea Kazumi Shimada¹, Manuel Santos da Cruz Neto¹, Lucila Soares da Silva Rocha¹, Publio Cesar Cavalcante Viana², Esper George Kallas³, Artur Katz¹

Affiliation(s)

¹Centro de Oncologia, Hospital Sírio-Libanês, Sao Paulo, Brazil.
²Radiologia Intervencionista, Hospital Sírio-Libanês, Sao Paulo, Brazil.
³Infectious Disease, Hospital Sírio-Libanês, Sao Paulo, Brazil.

ABSTRACT

Background: Crizotinib is a tyrosine kinase inhibitor of ALK, MET and ROS1. In a safety database trial, it was suggested an association of Crizotinib with the development of renal cyst in patients with non-small-cell lung cancer (NSCLC). Aim: To report an uncommon side effect of Crizotinib in a patient with NSLC. Case Presentation: We report the case of a 68-year-old woman with NSCLC who developed bilateral progressive aseptic renal abscesses during Crizotinib treatment. Conclusion: Further studies may be necessary to determinate the risk of renal cyst development and the management of these complications.

KEYWORDS

Non-Small-Cell Lung Cancer, Crizotinib, Renal Abscesses

Share and Cite:

de Carvalho, L. , Shimada, A. , da Cruz Neto, M. , da Silva Rocha, L. , Viana, P. , Kallas, E. and Katz, A. (2015) Development of Aseptic Renal Abscess in a Patient with Non-Small-Cell Lung Cancer with ALK Translocation during Crizotinib Treatment. Advances in Lung Cancer, 4, 53-57. doi: 10.4236/alc.2015.44007.

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