Author(s)

Rhian Sian Davies^1*, Toby Wells², Sarah Gwynne¹

¹Department of Clinical Oncology, Singleton Hospital, Swansea, UK.
²Department of Radiology, Singleton Hospital, Swansea, UK.

A 67-year-old female patient presented with weight loss, diarrhoea and thrombocytopaenia of unknown aetiology. A computerised tomography (CT) scan demonstrated a mass in the head of the pancreas with liver metastases. A liver biopsy demonstrated a well-differentiated neuroendocrine carcinoma. She was commenced on a somatostatin analogue. Three months later she presented with spontaneous bleeding. Blood test demonstrated results consistent with disseminated intravascular coagulation (DIC). A restaging CT scan showed evidence of disease progression. The DIC was felt to be due to the underlying progressive malignancy. Having considered the potential risks associated with cytotoxic therapy in the context of a consumptive coagulopathy, the patient was commenced on weekly Carboplatin. The patient’s blood counts improved rapidly, and her bruising and bleeding resolved. Following a few weeks of stable blood results and clinical stability, her cytotoxic treatment was changed to a combination of Carboplatin and Etoposide, and to date she remains well on treatment.

Pancreatic Neuroendocrine Tumour, Disseminated Intravascular Coagulation, Consumptive Coagulopathy

Davies, R. , Wells, T. and Gwynne, S. (2014) Disseminated Intravascular Coagulation in a Patient with Metastatic Pancreatic Neuroendocrine Tumour: A Case Report and Review of the Literature. Case Reports in Clinical Medicine, 3, 549-553. doi: 10.4236/crcm.2014.310119.