Adherence of a Clinical Strain of Mycoplasma fermentans to Human Cultured Epithelial Cells - Advances in Microbiology

AiM > Vol.4 No.11, September 2014

Advances in Microbiology

Volume 4, Issue 11 (September 2014)

ISSN Print: 2165-3402 ISSN Online: 2165-3410

Google-based Impact Factor: 1.18 Citations h5-index & Ranking

Adherence of a Clinical Strain of Mycoplasma fermentans to Human Cultured Epithelial Cells ()

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Download as PDF (Size: 4980KB) PP. 726-735

DOI: 10.4236/aim.2014.411079 3,622 Downloads 4,803 Views Citations

Author(s)

Mónica Rosales-Pérez, Silvia Giono-Cerezo, Jorge Girón, Antonio Yáñez, Lilia Cedillo

Affiliation(s)

Centro de Detección Biomolecular, VI.E.P., B.U.A.P. Puebla, Pue. México.
Escuela Nacional de Ciencias Biológicas, I.P.N, México, D. F. México.
Facultad de Agrobiología, Universidad Autónoma de Tlaxcala, México.
Facultad de Estomatología, B.U.A.P. Puebla, México.

ABSTRACT

This study compares the kinetics of adherence of both the prototype strain PG-18 and the recently clinically isolated strain P-140 of Mycoplasma fermentans to HEp-2 cells. M. fermentans may induce respiratory and genitourinary tract infections. We investigated the presence of putative adhesins from strain P-140. A surface protein of 47 kDa, labeled SP47, isolated from M. fermentans P-140, seems to be involved in acterial adherence on HEp-2 cells; this study could allow helping understand the interaction between mycoplasmas and their hosts. Anti-SP47 antibodies inhibited the formation of bacterial clusters and adherence to cultured cells, quantified by ELISA. M. fermentans P-140 was more efficient at adhering to cultured HEp-2 cells than PG-18.

KEYWORDS

Mycoplasma fermentans, Mycoplasmas, Adherence, Pathogenesis

Share and Cite:

Rosales-Pérez, M. , Giono-Cerezo, S. , Girón, J. , Yáñez, A. and Cedillo, L. (2014) Adherence of a Clinical Strain of Mycoplasma fermentans to Human Cultured Epithelial Cells. Advances in Microbiology, 4, 726-735. doi: 10.4236/aim.2014.411079.

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