A New and Efficient Method for the Synthesis of Pyrimido[2,1-b]Benzothiazole Derivatives - International Journal of Organic Chemistry

IJOC > Vol.2 No.1, March 2012

International Journal of Organic Chemistry

Volume 2, Issue 1 (March 2012)

ISSN Print: 2161-4687 ISSN Online: 2161-4695

Google-based Impact Factor: 1.26 Citations

A New and Efficient Method for the Synthesis of Pyrimido[2,1-b]Benzothiazole Derivatives ()

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Download as PDF (Size: 191KB) PP. 31-37

DOI: 10.4236/ijoc.2012.21006 8,458 Downloads 17,386 Views Citations

Author(s)

Fatemeh Chadegani, Fatemeh Darviche, Saeed Balalaie

Affiliation(s)

Peptide Chemistry Research Center, K. N. Toosi University of Technology, Tehran, Iran.

ABSTRACT

The one-pot three-component reaction of 2-aminobenzothiazole, benzaldehyde derivatives and β-ketoester, β-diketone or malonate derivatives in solvent-free conditions provides the corresponding pyrimido [2,1-b] benzothiazole derivatives at 60?C in 60% - 72% yields without using any catalyst in an optimistic time.

KEYWORDS

4H-Pyrimido [2, 1-b] Benzothiazole; Tandem Knoevenagel-Michael Reaction; One-Pot Reaction; Green Chemistry

Share and Cite:

F. Chadegani, F. Darviche and S. Balalaie, "A New and Efficient Method for the Synthesis of Pyrimido[2,1-b]Benzothiazole Derivatives," International Journal of Organic Chemistry, Vol. 2 No. 1, 2012, pp. 31-37. doi: 10.4236/ijoc.2012.21006.

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