Epidemiological Profile of Chronic Kidney Disease at the General Hospital of National Reference of N ’ Djamena ( Chad )

Introduction: Chronic renal failure is a disease that affects many patients worldwide and increasingly in Africa. At the end of 2003, about 1.1 million people were suffering from End-Stage Renal Disease (ESRD) and were treated with periodic dialysis [12]. In Africa, CKF represents 2% to 10% of hospital admissions and is responsible for 4% to 22% of deaths [14]. So, this study is conducted for the first time in Chad, with the aims to determine the prevalence of CKD. Methods: This was a retrospective, descriptive and analytical study over a period of 12 months from April 29, 2011 to April 28, 2012. All patients with chronic renal failure regardless of etiology and stage of chronic kidney disease were included in the study. Chronic renal failure was defined as a glomerular filtration rate below 60 ml/min/1.73m (MDRD) for more than 3 months. This study was conducted in several departments of the National General Reference Hospital (NGRH) of N’Djamena. Result: Among 2039 inpatients, 195 patients had chronic renal failure, as a frequency of 9.6%. The average age of our patients was 51 ± 16.8 years, ranging from 11 to 85 years. Male predominance was noted to be 59% of men against 41% of women. We noted that high blood pressure accounted for 66.2% (N = 129) of cases, diabetes in 48.2% (N = 94), alcoholism in 28.7% (N = 56), smoking in 14.9% (N = 29) and the association alcoholism-smoking in 19.5% (N = 38). Hypertension was the leading cause of chronic renal failure (66.2%). All patients had a serum creatinine and creatinine clearance was assessed. Among them, we noted 57 patients (29%) with end-stage renal failure. The average calcium and phosphate serum were 1.8 mmol/l and 1.6 mmol/l, respectively. We How to cite this paper: Hamat, I., Mahamat Abderraman, G., Moussa Tondi, Z.M., Youssouf, M., Cisse, M.M., Tara, F., Ka, E.F., Niang, A. and Diouf, B. (2016) Epidemiological Profile of Chronic Kidney Disease at the General Hospital of National Reference of N’Djamena (Chad). Open Journa of Nephrology, 6, 78-85. http://dx.doi.org/10.4236/ojneph.2016.63010 Received: August 24, 2016 Accepted: September 16, 2016 Published: September 19, 2016 Copyright © 2016 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access


Introduction
Chronic kidney disease is a major public health challenge in terms of social and human costs [1].The number of patients with chronic kidney disease increased in a major way in the world over the past decade.Worldwide at the end of 2003, about 1.1 million people were suffering from End-Stage Renal Disease (ESRD) and were treated with periodic dialysis [2].In France, there were 37,430 patients treated by dialysis in 2010 (an increase of 12% since 2006), a prevalence of 720 per million population [3].In Africa, CKF represents 2% to 10% of hospital admissions and is responsible for 4% -22% of deaths [4].In Côte d'Ivoire, at the internal medicine department of CHU Treichville, it was the second cause of death with a prevalence of 6.14% [4].In Senegal, the hospital incidence is estimated at 87 new cases per year [5].In Chad, we do not have any statistics on kidney disease.The first unit of Nephrology-Hemodialysis was born in 2011.
Kidney diseases are under diagnosed and patients were seen in specialized nephrology consultation at chronic renal failure indeed end stage.That's why we initiated this study whose objectives were to determine the epidemiological profile of patients with chronic renal failure.This study had been conducted within the General Hospital of National Reference in N'Djamena over a period of one year (2011-2012).Level 3 hospital with 260 beds is the biggest hospital in Chad.

Material and Methods
This was a retrospective, descriptive and analytical study over a period of 12 months from April 29, 2011 to April 28, 2012.Were included in the study, all patients with chronic renal failure regardless of etiology and stage of chronic kidney disease.Chronic renal failure was defined as a glomerular filtration rate below 60 ml/min/1.73m(MDRD) for more than 3 months.This study was conducted in several departments of the National General Reference Hospital (NGRH) of N'Djamena: cardiology, infectious disease and nephrology.The NGRH is a national public health reference (level) III facility with a capacity of 260 beds located in the capital N'Djamena, Chad.This is the second reference nephrology department of the country.Nephrology department staff consists of two nephrologists, a general practitioner and three interns.The renal unit further includes a hospitalization sector equipped with 8 beds.The parameters studied were epidemiological, clinical, biological and therapeutic.The qualitative variables were represented by gender, occupation, risk factors and clinical signs.Quantitative variables were represented by age, different stages of CKD and biochemical exams: hemoglobin, serum phosphate, serum calcium, uric acid.These data were collected using a survey according to patient records.Some patients have been contacted if their file was incomplete with their prior consent.Were excluded from the study, all patients with acute renal failure and those who didn't give their consent.Data were entered and analyzed using SPSS 18 software and were processed by univariate bivariate analysis.

Results
During this period, 2039 patients were hospitalized for kidney failure in the various service of the GHNR.Among them, 195 patients had met the inclusion criteria as 9.6% of cases.The other patients were not selected because they presented acute renal failure which have recovered, had incomplete files or had not or had not given their consent.

Age
The average age was 51.8 ± 16.8 years and extreme ranging from 11 years to 85 years.
The age group between 45 to 64 years accounted for 44.10% of all cases.Distribution according to ages is summarized in Figure 1.

Gender
Our study population consisted of 114 men and 81 women with a sex ratio of 1.4.

Clinical Characteristic
We noted that 54.4% of patients were hospitalized in cardiology as shown in Figure 2.

Risk Factors
We noted that high blood pressure account for 66.2% (N = 129) of cases, diabetes

Stages of Chronic Kidney Disease
We noted in Figure 3 that 57 of 195 registered patients as 29% had end-stage renal disease (Stage V).

Distribution of Age according to CKD Stages
In the proportion of 57 (29%) patients in CKD5, 44 patients were aged between 25 and 64 years as 77.20%.The rest of the results is summarized in Figure 4.

Paraclinical Parameters
The average calcium and phosphate serum were respectively 1.8 mmol/l (standards laboratory for normal serum calcium is between 2.2 and 2.6 mmol/l) and 1.6 mmol/l (standards laboratory for normal serum phosphate is between 0.8 and 1.45 mmol/l).
Parathyroid hormone and 25-OH vitamin D were not dosed at General Hospital of national reference.
Table 1 summarizes the main measured biological parameters.

Therapeutic
We noted that 120 patients (61.5%), were taking herbal medicine as shown in Table 2.
There was 5.7% (N = 11) of patients taking the native vitamin D (25 OH vitamin D) and 61.4% (N = 119) who had a calcium supplementation as calcium carbonate.48 out of 57 of our patients with ESRD (24.6%) in the study are treated with chronic conventional hemodialysis at 2 session of 5 hours per week.30patients hemodialysis with arteriovenous fistulas, 8 patients through tunneled catheters and 10 patients with nonpermanent central catheters.Among these patients, there were 12.5% of death.

Discussion
This work is the first step of a series.It shows that the epidemiology of chronic renal failure in the General Hospital national reference was 9.6%.The results were set out overall.This work is limited by the small sample and the absence of multivariate analysis.The variables need to be expanded especially to socio-professional data, risk factors, namely smoking, alcoholism and paraclinical data such as ultrasound and lipid profile.years was the most affected by IRC, as 62% of cases.It follows that the affected population is young and the results are similar to those found in some studies in Africa [6] [7]; by against the results noted in some developed countries showed that patients affected by IRC have an average age above 60 years [8] [9].This discrepancy is explained by the fact that in Western countries there is greater access to care, preventive means and could diagnostic performance, a management of patients with faster and more adequate renal failure.Sex ratio was 1.4.The same result was observed in most studies [8] [9].It was noted a higher proportion of patients hospitalized in cardiology (54.4%).This could be explained by the fact that a large majority of patients in the study were hypertensive and diabetic.Those two pathologies are providers of pericardial and renal dysfunction.
Hypertension was found in 129 patients (66.2%).It is the leading cause of vascular nephropathy and therefore represents one of the main etiologies of CKD in our study.
It is as an essential factor of renal disease progression.His balance is essential to stabilize the chronic renal failure.However, we noted that only 25 hypertensive patients (12.8%) were on antihypertensive treatment.This low patients treaties is explained by the low socioeconomic level to buy medicines, to poor adherence and local beliefs that would guide patients to use traditional herbal medicine.
Diabetes is the second leading cause.This shows the role of diabetes in the onset of diabetic nephropathy which is one of the causes of CKD in our study.Studies conducted in France and the United States of America had found that the most frequent cardiovascular risk factor was diabetes [8] [9].
These backgrounds are known to be important factors for onset or worsening of CKD [10]- [12].
The primary cause of CKD varies among studies, and can be nephroangiosclerosis [13], diabetic nephropathy or chronic glomerulonephritis [14].The variation reflects differences in the prevalence of kidney disease among countries.
These increases indicate the severity of the loss of renal function of patients.The end stage renal disease accounted for 29% of cases.This often explains the delay of initial diagnosis of CKD.
Forty-eight out of 57 of our patients with ESRD hence 84.2% had received chronic intermittent hemodialysis.The recommended frequency of hemodialysis sessions is three per week.But two sessions per week were set for most cases due to lack of hemodialysis generators.Ideal for vascular access in hemodialysis is that all chronic hemodialysis patients must have an arteriovenous fistula.But in our study, few patients were receiving dialysis arteriovenous fistula by venous.This is due to a faulty technical platform.Kidney transplant was not performed in any of patients in our series.
During our management in hemodialysis 12.5% of our patients died in a state of poor adherence to lifestyle modifications and therapy and because of severe uremia, advanced kidney disease diagnosed at advanced stage and under dialysis.
Vitamin D are three types of effects on the vascular system: anti-inflammatory, reducing myocardial hypertrophy, inhibition of the renin-angiotensin system.Thus treatment with a form "inactive" of vitamin D, or 25(OH)D is a new approach for patients with CKD.There was a very small proportion of patient (5.7%) was in vitamin D. This is due to the fact that the molecule does not exist on the local market.

Conclusion
Chronic kidney disease is a silent and long disease.In Chad, at General Hospital of National Reference, the proportion of CKD patient is 9.6%.We noted that 30% of CKD patients were in end-stage renal disease.Despite the growing number of chronic renal insufficient patients in Chad, their care, as in most African countries still suffers lack of specialized structures.Reducing the morbidity and mortality of this condition requires early diagnosis and management of cardiovascular risk factors.This work is limited by the small sample and the absence of several clinical and paraclinical parameters for multivariate analyzes.In future prospects, this study will be extended to other peripheral hospitals in N'Djamena and other cities in order to obtain more representative results.

Figure 1 .
Figure 1.Distribution of patients according to age group.

Figure 2 .
Figure 2. Distribution of patients according to specialties.

Figure 3 .
Figure 3. Distribution of patients by stage of CKD.

Figure 4 .
Figure 4. Distribution of age according to CKD stages.

Table 2 .
Distribution of patients according to treatment received before hospitalization.