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Dr. Yuan‑Shan Zhu

Weill Cornell Medical College, USA

Email: yuz2002@med.cornell.edu


1987 Ph.D., Cornell University Graduate School of Medical Science, USA

1978 M.Sc., Xiangya School of Medicine of Central South University, China

Publications (selected)

  1. Qiao Y, Zhang Z-k, Cai LQ, Tan C, Julianne L. Imperato-McGinley and Zhu YS*: 17alpha-Estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals. The Prostate, 67(16):1719-1728, 2007
  2. Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ: Subcellular proteome analysis of camptothecin analog NSC606985-treated acute myeloid leukemic cells. J Proteome Res.  6(9):3808-18, 2007
  3. Butler T, Pan H, Imperato-McGinley J, Voyer D, Cunningham-Bussel AC, Cordero JJ, Zhu YS, Silbersweig D, Stern E: A network approach to fMRI condition-dependent cognitive activation studies as applied to understanding sex differences. Clinical Neuroscience Research, 6(6):391-398, 2007
  4. Zhu YS* and Imperato-McGinley J: Male sexual differentiation disorder and 5a-reductase-2 deficiency. Journal of Global Library of Women's Medicine (ISSN: 1756-2228) 2008; DOI 10.3843/GLOWM.10350
  5. Tan C, Cai LQ, Wu W, Qiao Y, Julianne Imperato-McGinley, Chen GQ, and Zhu YS*: NSC606985, A novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells. Cancer Chemotherapy and Pharmacology, 63(2):303-312, 2009 (Epub March 29, 2008)
  6. Zhu YS* and Imperato-McGinley J: Disorders in male sexual differentiation: molecular genetics, gender identity, and cognition, in Hormones, Brain and Behavior. Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE and Rubin RT (eds), 2nd ed, Vol 5, Academic Press, San Diego, CA. pp2787-2824, 2009
  7. Zhu YS* and Imperato-McGinley JL: 5a-Reductase isozymes and androgen actions in the prostate. Annals of New York Academy of Sciences, 1155:43-56, 2009
  8. Zhu YS* and Imperato-McGinley J: Genetic defects of male sexual differentiation, in Hormone/Behavior Relations of Clinical Importance. Rubin RT and Pfaff DW (eds), Academic Press, Orlando, Florida, pp743-780, 2009
  9. Zhang N, Zhang HW, Xia L, Zheng Y, Yu Y, Zhu YS, Chen GQ, Di W: NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1 alpha protein in human ovarian cancer cells. Cancer Letters, 278(2):139-144, 2009
  10. Qiao Y, Wang L, Cai LQ, Tan C, Imperato-McGinley J and Zhu YS*: Inhibition of aberrant androgen receptor induction of prostate specific antigen gene expression, cell proliferation and tumor growth by 17a-estradiol in prostate cancer. J Urology, 185:305-314, 2011, PMID:21075385,  PMC3039213
  11. Cai J, Yuan H, Weng C, Tan C, Imperato-McGinley J and Zhu YS*: Androgens stimulate human aortic endothelial cell proliferation through an androgen receptor-VEGF/cyclin A mediated mechanism. Am J Physiol Heart Circ Physiol, 300(4):H1210-1221, 2011
  12. Kang H, Imperato-McGinley J, Zhu YS, Cai LQ, Cordero J, Schlegel P, Palermo G and Rosenvaks R: The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation. Fertil Steril, 95(6):2125.e5-8, 2011, PMID:21334614
  13. Cai LQ, Cai J, Wu W and Zhu YS*: 17a-estradiol and genistein inhibit a high-fat diet induced prostate gene expression and prostate growth in the rat. J Urology, 186 (40):1489-1496, 2011, PMID: 21855913
  14. Cai J, Cai LQ, Yuan H and Zhu YS*: Functional characterization of an androgen receptor mutation causing human androgen insensitivity syndrome. Andrologia, 44:523-9, 2012, PMID:21950590
  15. Cai J, Cao Y, Yuan H, Yang K, and Zhu YS: Inferior Myocardial infarction Secondary to Aortic Dissection (AD) Associated to Bicuspid Aortic Valve (BAV). J Cardiovasc Dis Res, 3(2):138-142, 2012, PMID:22629034, PMCID:PMC3354459
  16. Weng C, Cai J, Wen J, Yuan H, Tan C, Imperato-McGinley, and Zhu YS*: Differential effects of estrogen receptor ligands on regulation of dihydrotestosterone-induced cell proliferation in endothelial and prostate cancer cells. Int J Oncol, 42(1):327-37, 2013, PMID: 23135751
  17. Wen J, Zhao Y, Li J, Weng C, Cai J, Yang K, Yuan H, Imperato-McGinley J, Zhu YS*: Suppression of DHT-induced paracrine stimulation of endothelial cell growth by estrogens via prostate cancer cells. Prostate, 2013 Feb 19. doi: 10.1002/pros.22654. [Epub ahead of print], PMID:23423946
  18. Perez Bay AE, Schreiner R, Mazzoni F, Carbajal-Gonzalez J, Gravotta D, Perret E, Lehmann-Mantaras G, Zhu YS and Rodriguez-Boulan E: The Kinesin KIF16B mediates Apical Transcytosis of Transferrin Receptor in AP-1B deficient epithelia. EMBO J, accepted