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Biography

Dr. Chang-Hui Shen

City University of New York, USA


Email: Changhui.shen@csi.cuny.edu


Qualifications

1998  Ph.D., University of Edinburgh, U.K.

1992  M.Sc., National Chung-Hsing University, Taiwan

1990  B.Sc., National Chung-Hsing University, Taiwan


Publications (selected)

  1. Wimalarathna R., Pan PY., and Shen C-H. Codependent recruitment of Ino80p and Snf2p is required for yeast CUP1 activation. Biochemistry and Cell Biology.
  2. El Idrissi A., Shen C-H., and L’Amoreaux WJ. (2013),  Neuroprotective role of Taurine during aging. Amino Acids, 45, 735-750.
  3. Shen C-H., Lempert E., Butt I., Neuwirth LS., Yan X., and El Idrissi A. (2013), Changes in gene expression at inhibitory synapses in responses to Taurine treatment. In: Abdeslem El Idrissi and William L’Amoreaux, Taurine 8: Physiological and mechanisms of action, p.p. 187-194, Springer, New York. ISBN-978-1-4614-6129-6.
  4. Shen C-H. (2012), Linker histones and chromatin structure. In: Chang-Hui Shen. Histones: Class, Structure and Function, p.p. 35-57, Nova Science Publisher, Inc. NY. ISBN: 978-1-62100-274-1.
  5. Wimalarathna R., and Shen C-H. (2012), Histone modifications and gene expression. In: Chang-Hui Shen. Histones: Class, Structure and Function, p.p. 89-108, Nova Science Publisher, Inc. NY. ISBN: 978-1-62100-274-1.
  6. Hong A., Zhang A., Ke Y., El Idrissi A., and Shen C-H. (2012), Decreased expression of GABAA b Subunits in the Brains of Mice Lacking the Fragile X Mental Retardation Protein. Journal of Molecular Neuroscience, 46, 272-275.
  7. Wimalarathna RN., Pan PY., and Shen C-H. (2012), Chromatin repositioning activity and transcription machinery are both recruited by Ace1p in yeast CUP1. Biochemical and Biophysical Research Communications, 422, 658-663.
  8. Konarzewska P., Esposito M., and Shen C-H. (2012), INO1 induction requires chromatin remodelers Ino80p and Snf2p but not the histone acetylases. Biochemical and Biophysical Research Communications, 418, 483-488.
  9. Wimalarathna RN., Tsai C-H., and Shen C-H. (2011), Transcriptional regulation of genes involved in yeast phospholipid biosynthesis. Journal of Microbiology, 49, 265-273.
  10. Esposito M., Konarzewska P., Odeyale O., and Shen C-H. (2010), Activator-dependent recruitment of histone acetylation at the yeast INO1 promoter. Biochemical and Biophysical Research Communications, 391, 1285-1290.
  11. Zhang A., Shen C-H., Ma SY., Ke Y., and El Idrissi A. (2009), Altered expression of Autism-associated genes in the brain of Fragile X mouse model. Biochemical and Biophysical Research Communications, 379, 920-923.
  12. Ford J., Odeyale O., and Shen C-H. (2008), Activator-dependent recruitment of SWI/SNF and INO80 during INO1 activation. Biochemical and Biophysical Research Communications, 373, 602-606.
  13. Ford J., Odeyale O., Eskandar A., Kouba N., and Shen C-H. (2007), A SWI/SNF- and INO80-dependent nucleosome movement at the INO1 promoter. Biochemical and Biophysical Research Communications, 361, 974-979.
  14. Clark D., and Shen C-H. (2006), Mapping histone modifications by nucleosome immunoprecipitation. Methods in Enzymology, 410, 416-430.
  15. Mendiratta G., Eriksson PR., Shen C-H., and Clark D. (2006), The DNA-binding domain of the yeast Spt10 activator includes a zinc finger that is homologous to foamy virus integrase. Journal of Biological Chemistry, 281, 7040-7048.
  16. Eriksson PR., Mendiratta G., McLaughlin N., Wolfsberg T., Maríño-Ramirez L., Pompa T., Jainerin M., Landsman D., Shen C-H., and Clark DJ. (2005), The putative histone acetyltransferase encoded by the yeast SPT10 gene binds specifically to upstream activating sequences in the major core histone promoters. Molecular and Cellular Biology, 25, 9127-9137.
  17. Kim YJ., Shen C-H., and Clark DJ. (2004), Purification and nucleosome mapping analysis of native yeast plasmid chromatin. Methods, 33, 59-67.
  18. Shen C-H., Leblanc B., Neal C., Akhavan R., and Clark DJ. (2002), Targeted histone acetylation at the yeast CUP1 promoter requires the transcriptional activator, the TATA boxes, and the putative histone acetylase encoded by SPT10. Molecular and Cellular Biology, 22, 6406-6416.
  19. Shen C-H., Leblanc B., Alfieri J., and Clark DJ. (2001), Remodeling of yeast CUP1 chromatin involves activator-dependent repositioning of nucleosomes over the entire gene and flanking sequences. Molecular and Cellular Biology, 21, 534-547.
  20. Shen C-H., and Clark DJ. (2001), DNA sequence plays a major role in determining nucleosome positions in yeast CUP1 chromatin. Journal Biological Chemistry, 276, 35209-35216.